Brand  (β version)

PDB ID: 5W5Q

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Ligands
Code Name Style Show Link
9X4 (5s,7s)-N~3~-methyl-10-[3-methyl-3-(5-methyl-1,3-oxazol-2-yl)but-1-yn-1-yl]-6,7-dihydro-5h-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide PoSSuM
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Structure summary

Code : 5W5Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[C]imidazo[1,2-a]azepine-2,3-dicarboxamide)
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase kinase kinase kinase 4 A,B HPK/GCK-like kinase HGK,MAPK/ERK kinase kinase kinase 4,MEKKK 4,Nck-interacting kinase
ec: 2.7.11.1
fragment: UNP residues 2-328
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAP4K4, HGK, KIAA0687, NIK
Authors : Harris, S.F., Wu, P.
Keywords : kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.3300 Å )
Citation :

Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).

Feng, J.A.,Lee, P.,Alaoui, M.H.  et al.
(2019)  Acs Med.Chem.Lett.  10 : 1260 - 1265

PubMed: 31531194
DOI: 10.1021/acsmedchemlett.8b00658

Structure based design of potent selective inhibitors of protein kinase D1 (PKD1)

Feng, J.W.,Lee, P.,Alaoui, M.H.  et al.
(2019)  Acs Med.Chem.Lett. 

DOI: 10.1021/acsmedchemlett.8b0065

Reaction

Chain : A, B
UniProt : O95819 (M4K4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:9890973
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:9890973
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