ID 5W5QA STANDARD; PRT; 332 AA. DT CONVERTED FROM PDB (SEQRES) 5W5Q DE Mitogen-activated protein kinase kinase kinase kinase 4 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.330 CC R-Factor 0.211 FT #SUB 31 30 VAL A 39 38 GLN B Protein S 1 FT #SUB 34 33 ASN A 185 184 ARG B Protein B 1 FT #SUB 35 34 GLY A 189 188 PHE B Protein B 2 FT #SUB 38 37 GLY A 35 34 GLY B Protein B 2 FT #SUB 39 38 GLN A 34 33 ASN B Protein S 9 FT #SUB 39 38 GLN A 38 37 GLY B Protein S 1 FT #SUB 39 38 GLN A 39 38 GLN B Protein S 3 FT #SUB 41 40 TYR A 39 38 GLN B Protein S 2 FT #SUB 58 57 ASP A 34 33 ASN B Protein S 1 FT #SUB 181 180 ARG A 236 235 ASP B Protein B 3 FT #SUB 182 181 THR A 235 234 CYS B Protein A 6 FT #SUB 182 181 THR A 236 235 ASP B Protein B 1 FT #SUB 183 182 VAL A 235 234 CYS B Protein A 2 FT #SUB 183 182 VAL A 236 235 ASP B Protein S 2 FT #SUB 183 182 VAL A 237 236 MET B Protein S 2 FT #SUB 185 184 ARG A 158 157 GLN B Protein S 2 FT #SUB 187 186 ASN A 239 238 PRO B Protein B 2 FT #SUB 188 187 THR A 192 191 THR B Protein B 3 FT #SUB 188 187 THR A 193 192 PRO B Protein B 1 FT #SUB 188 187 THR A 194 193 TYR B Protein A 3 FT #SUB 188 187 THR A 239 238 PRO B Protein B 3 FT #SUB 189 188 PHE A 191 190 GLY B Protein S 2 FT #SUB 189 188 PHE A 192 191 THR B Protein S 7 FT #SUB 190 189 ILE A 189 188 PHE B Protein B 1 FT #SUB 190 189 ILE A 190 189 ILE B Protein A 9 FT #SUB 190 189 ILE A 191 190 GLY B Protein A 8 FT #SUB 190 189 ILE A 239 238 PRO B Protein S 4 FT #SUB 190 189 ILE A 240 239 MET B Protein S 2 FT #SUB 190 189 ILE A 243 242 LEU B Protein S 1 FT #SUB 191 190 GLY A 189 188 PHE B Protein B 4 FT #SUB 191 190 GLY A 190 189 ILE B Protein B 3 FT #SUB 192 191 THR A 188 187 THR B Protein A 6 FT #SUB 192 191 THR A 189 188 PHE B Protein A 2 FT #SUB 193 192 PRO A 188 187 THR B Protein S 1 FT #SUB 193 192 PRO A 190 189 ILE B Protein S 2 FT #SUB 194 193 TYR A 188 187 THR B Protein S 1 FT #SUB 196 195 MET A 240 239 MET B Protein S 1 FT #SUB 200 199 VAL A 240 239 MET B Protein B 1 FT #SUB 202 201 ALA A 244 243 PHE B Protein A 6 FT #SUB 203 202 CYS A 244 243 PHE B Protein B 5 FT #SUB 204 203 ASP A 204 203 ASP B Protein A 6 FT #SUB 204 203 ASP A 248 247 ARG B Protein S 2 FT #SUB 205 204 GLU A 204 203 ASP B Protein S 1 FT #SUB 207 206 PRO A 241 240 ARG B Protein B 1 FT #SUB 207 206 PRO A 244 243 PHE B Protein A 5 FT #SUB 208 207 ASP A 241 240 ARG B Protein S 2 FT #SUB 239 238 PRO A 188 187 THR B Protein S 3 FT #SUB 239 238 PRO A 189 188 PHE B Protein S 1 FT #SUB 240 239 MET A 200 199 VAL B Protein S 2 FT #SUB 240 239 MET A 202 201 ALA B Protein A 4 FT #SUB 241 240 ARG A 207 206 PRO B Protein S 5 FT #SUB 241 240 ARG A 208 207 ASP B Protein S 3 FT #SUB 243 242 LEU A 190 189 ILE B Protein S 1 FT #SUB 243 242 LEU A 243 242 LEU B Protein S 1 FT #SUB 244 243 PHE A 203 202 CYS B Protein S 4 FT #SUB 244 243 PHE A 204 203 ASP B Protein S 2 FT #SUB 244 243 PHE A 207 206 PRO B Protein S 5 FT #SUB 248 247 ARG A 204 203 ASP B Protein S 3 FT #HET 32 31 VAL A 1 401 9X4 A S 4 FT #HET 33 32 GLY A 1 401 9X4 A B 1 FT #HET 34 33 ASN A 1 401 9X4 A B 2 FT #HET 35 34 GLY A 1 401 9X4 A B 1 FT #HET 40 39 VAL A 1 401 9X4 A S 10 FT #HET 53 52 ALA A 1 401 9X4 A S 4 FT #HET 55 54 LYS A 1 401 9X4 A S 2 FT #HET 74 73 LEU A 1 401 9X4 A S 3 FT #HET 78 77 SER A 1 401 9X4 A S 1 FT #HET 84 83 ALA A 1 401 9X4 A B 2 FT #HET 86 85 TYR A 1 401 9X4 A A 3 FT #HET 104 103 LEU A 1 401 9X4 A S 1 FT #HET 106 105 MET A 1 401 9X4 A S 12 FT #HET 107 106 GLU A 1 401 9X4 A B 3 FT #HET 108 107 PHE A 1 401 9X4 A A 6 FT #HET 109 108 CYS A 1 401 9X4 A A 9 FT #HET 112 111 GLY A 1 401 9X4 A B 1 FT #HET 158 157 GLN A 1 401 9X4 A A 2 FT #HET 161 160 LEU A 1 401 9X4 A S 7 FT #HET 171 170 VAL A 1 401 9X4 A A 10 FT #HET 172 171 ASP A 1 401 9X4 A A 12 FT DISORDER 1 17 FT DISORDER 95 98 FT DISORDER 313 332 CC SEQUENCE 291 AA (ATOM); CC SLRDPAGIFE LVEVVGNGTY GQVYKGRHVK TGQLAAIKVM DVTEDEEEEI KLEINMLKKY CC SHHRNIATYY GAFIKKSDDQ LWLVMEFCGA GSITDLVKNT KGNTLKEDWI AYISREILRG CC LAHLHIHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR TVGRRNTFIG TPYWMAPEVI CC ACDENPDATY DYRSDLWSCG ITAIEMAEGA PPLCDMHPMR ALFLIPRNPP PRLKSKKWSK CC KFFSFIEGCL VKNYMQRPST EQLLKHPFIR DQPNERQVRI QLKDHIDRTR K CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQ CC ATOM -----------------SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQ CC ********************************* CC SEQRES LAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDD CC ATOM LAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKS----DD CC ******************************************** ** CC SEQRES QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHV CC ATOM QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHV CC ************************************************** CC SEQRES IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV CC ATOM IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV CC ************************************************** CC SEQRES IACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNP CC ATOM IACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNP CC ************************************************** CC SEQRES PPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR CC ATOM PPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR CC ************************************************** CC SEQRES IQLKDHIDRTRKKRGEKDETEYEYSGSEEGNS CC ATOM IQLKDHIDRTRK-------------------- CC ************ SQ SEQUENCE 332 AA; MW; CN; GSANDSPAKS LVDIDLSSLR DPAGIFELVE VVGNGTYGQV YKGRHVKTGQ LAAIKVMDVT EDEEEEIKLE INMLKKYSHH RNIATYYGAF IKKSPPGHDD QLWLVMEFCG AGSITDLVKN TKGNTLKEDW IAYISREILR GLAHLHIHHV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD RTVGRRNTFI GTPYWMAPEV IACDENPDAT YDYRSDLWSC GITAIEMAEG APPLCDMHPM RALFLIPRNP PPRLKSKKWS KKFFSFIEGC LVKNYMQRPS TEQLLKHPFI RDQPNERQVR IQLKDHIDRT RKKRGEKDET EYEYSGSEEG NS // ID 5W5QB STANDARD; PRT; 332 AA. DT CONVERTED FROM PDB (SEQRES) 5W5Q DE Mitogen-activated protein kinase kinase kinase kinase 4 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.330 CC R-Factor 0.211 FT #SUB 34 33 ASN B 39 38 GLN A Protein S 9 FT #SUB 34 33 ASN B 58 57 ASP A Protein B 1 FT #SUB 35 34 GLY B 38 37 GLY A Protein B 2 FT #SUB 38 37 GLY B 39 38 GLN A Protein B 1 FT #SUB 39 38 GLN B 31 30 VAL A Protein S 1 FT #SUB 39 38 GLN B 39 38 GLN A Protein S 3 FT #SUB 39 38 GLN B 41 40 TYR A Protein S 2 FT #SUB 158 157 GLN B 185 184 ARG A Protein S 2 FT #SUB 185 184 ARG B 34 33 ASN A Protein S 1 FT #SUB 188 187 THR B 192 191 THR A Protein A 6 FT #SUB 188 187 THR B 193 192 PRO A Protein B 1 FT #SUB 188 187 THR B 194 193 TYR A Protein S 1 FT #SUB 188 187 THR B 239 238 PRO A Protein B 3 FT #SUB 189 188 PHE B 35 34 GLY A Protein S 2 FT #SUB 189 188 PHE B 190 189 ILE A Protein S 1 FT #SUB 189 188 PHE B 191 190 GLY A Protein A 4 FT #SUB 189 188 PHE B 192 191 THR A Protein S 2 FT #SUB 189 188 PHE B 239 238 PRO A Protein B 1 FT #SUB 190 189 ILE B 190 189 ILE A Protein A 9 FT #SUB 190 189 ILE B 191 190 GLY A Protein A 3 FT #SUB 190 189 ILE B 193 192 PRO A Protein S 2 FT #SUB 190 189 ILE B 243 242 LEU A Protein S 1 FT #SUB 191 190 GLY B 189 188 PHE A Protein B 2 FT #SUB 191 190 GLY B 190 189 ILE A Protein B 8 FT #SUB 192 191 THR B 188 187 THR A Protein A 3 FT #SUB 192 191 THR B 189 188 PHE A Protein A 7 FT #SUB 193 192 PRO B 188 187 THR A Protein S 1 FT #SUB 194 193 TYR B 188 187 THR A Protein S 3 FT #SUB 200 199 VAL B 240 239 MET A Protein B 2 FT #SUB 202 201 ALA B 240 239 MET A Protein A 4 FT #SUB 203 202 CYS B 244 243 PHE A Protein B 4 FT #SUB 204 203 ASP B 204 203 ASP A Protein S 6 FT #SUB 204 203 ASP B 205 204 GLU A Protein S 1 FT #SUB 204 203 ASP B 244 243 PHE A Protein B 2 FT #SUB 204 203 ASP B 248 247 ARG A Protein A 3 FT #SUB 207 206 PRO B 241 240 ARG A Protein A 5 FT #SUB 207 206 PRO B 244 243 PHE A Protein A 5 FT #SUB 208 207 ASP B 241 240 ARG A Protein S 3 FT #SUB 235 234 CYS B 182 181 THR A Protein A 6 FT #SUB 235 234 CYS B 183 182 VAL A Protein B 2 FT #SUB 236 235 ASP B 181 180 ARG A Protein B 3 FT #SUB 236 235 ASP B 182 181 THR A Protein B 1 FT #SUB 236 235 ASP B 183 182 VAL A Protein B 2 FT #SUB 237 236 MET B 183 182 VAL A Protein B 2 FT #SUB 239 238 PRO B 187 186 ASN A Protein S 2 FT #SUB 239 238 PRO B 188 187 THR A Protein S 3 FT #SUB 239 238 PRO B 190 189 ILE A Protein A 4 FT #SUB 240 239 MET B 190 189 ILE A Protein A 2 FT #SUB 240 239 MET B 196 195 MET A Protein S 1 FT #SUB 240 239 MET B 200 199 VAL A Protein S 1 FT #SUB 241 240 ARG B 207 206 PRO A Protein S 1 FT #SUB 241 240 ARG B 208 207 ASP A Protein S 2 FT #SUB 243 242 LEU B 190 189 ILE A Protein S 1 FT #SUB 243 242 LEU B 243 242 LEU A Protein S 1 FT #SUB 244 243 PHE B 202 201 ALA A Protein S 6 FT #SUB 244 243 PHE B 203 202 CYS A Protein S 5 FT #SUB 244 243 PHE B 207 206 PRO A Protein S 5 FT #SUB 248 247 ARG B 204 203 ASP A Protein S 2 FT DISORDER 1 13 FT DISORDER 36 37 FT DISORDER 313 332 CC SEQUENCE 297 AA (ATOM); CC IDLSSLRDPA GIFELVEVVG NGGQVYKGRH VKTGQLAAIK VMDVTEDEEE EIKLEINMLK CC KYSHHRNIAT YYGAFIKKSP PGHDDQLWLV MEFCGAGSIT DLVKNTKGNT LKEDWIAYIS CC REILRGLAHL HIHHVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW CC MAPEVIACDE NPDATYDYRS DLWSCGITAI EMAEGAPPLC DMHPMRALFL IPRNPPPRLK CC SKKWSKKFFS FIEGCLVKNY MQRPSTEQLL KHPFIRDQPN ERQVRIQLKD HIDRTRK CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQ CC ATOM -------------IDLSSLRDPAGIFELVEVVGNG--GQVYKGRHVKTGQ CC ********************** ************* CC SEQRES LAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDD CC ATOM LAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDD CC ************************************************** CC SEQRES QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHV CC ATOM QLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHV CC ************************************************** CC SEQRES IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV CC ATOM IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEV CC ************************************************** CC SEQRES IACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNP CC ATOM IACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNP CC ************************************************** CC SEQRES PPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR CC ATOM PPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR CC ************************************************** CC SEQRES IQLKDHIDRTRKKRGEKDETEYEYSGSEEGNS CC ATOM IQLKDHIDRTRK-------------------- CC ************ SQ SEQUENCE 332 AA; MW; CN; GSANDSPAKS LVDIDLSSLR DPAGIFELVE VVGNGTYGQV YKGRHVKTGQ LAAIKVMDVT EDEEEEIKLE INMLKKYSHH RNIATYYGAF IKKSPPGHDD QLWLVMEFCG AGSITDLVKN TKGNTLKEDW IAYISREILR GLAHLHIHHV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD RTVGRRNTFI GTPYWMAPEV IACDENPDAT YDYRSDLWSC GITAIEMAEG APPLCDMHPM RALFLIPRNP PPRLKSKKWS KKFFSFIEGC LVKNYMQRPS TEQLLKHPFI RDQPNERQVR IQLKDHIDRT RKKRGEKDET EYEYSGSEEG NS //