PDB ID: 5VP0
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
ZN | Zinc ion | PoSSuM | |||
MG | Magnesium ion | PoSSuM | |||
9GJ | N-{(1s)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-B]pyrazine-4(1h)-carboxamide | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|
Download interaction data: 5VP0
Structure summary
Code : | 5VP0 PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-B]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders | ||||||||||||
Release Data : | 2017-08-23 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Hoffman, I.D. | ||||||||||||
Keywords : | Inhibitor, Phosphodiesterase, Brain-Pentrating, Cognitive Disorders, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.2000 Å ) | ||||||||||||
Citation : |
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.
Mikami, S.,Nakamura, S.,Ashizawa, T.
et al.
PubMed: 28796496 |
Reaction
Chain : | A, B, C | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProt : | O00408 (PDE2A_HUMAN) | |||||||||||||||||||
|