ID 5VP0A STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 5VP0 DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.213 FT #SUB 137 711 SER A 177 751 ARG B Protein B 3 FT #SUB 138 712 LYS A 177 751 ARG B Protein S 5 FT #SUB 138 712 LYS A 181 755 GLN B Protein S 5 FT #SUB 140 714 VAL A 161 735 ILE B Protein S 1 FT #SUB 140 714 VAL A 165 739 ASN B Protein S 3 FT #SUB 143 717 ALA A 157 731 PHE B Protein B 1 FT #SUB 143 717 ALA A 184 758 LEU B Protein S 1 FT #SUB 143 717 ALA A 188 762 ARG B Protein B 1 FT #SUB 144 718 LEU A 158 732 ALA B Protein S 1 FT #SUB 148 722 GLU A 148 722 GLU B Protein S 8 FT #SUB 148 722 GLU A 154 728 ARG B Protein S 2 FT #SUB 154 728 ARG A 148 722 GLU B Protein S 3 FT #SUB 157 731 PHE A 143 717 ALA B Protein S 1 FT #SUB 158 732 ALA A 144 718 LEU B Protein A 2 FT #SUB 161 735 ILE A 140 714 VAL B Protein S 1 FT #SUB 165 739 ASN A 140 714 VAL B Protein S 3 FT #SUB 177 751 ARG A 138 712 LYS B Protein A 4 FT #SUB 177 751 ARG A 266 840 MET B Protein S 2 FT #SUB 181 755 GLN A 138 712 LYS B Protein S 7 FT #SUB 184 758 LEU A 143 717 ALA B Protein S 1 FT #SUB 188 762 ARG A 142 716 ALA B Protein S 1 FT #SUB 188 762 ARG A 143 717 ALA B Protein S 5 FT #SUB 188 762 ARG A 146 720 SER B Protein S 1 FT #SUB 188 762 ARG A 147 721 SER B Protein S 2 FT #SUB 266 840 MET A 177 751 ARG B Protein S 1 FT #SUB 167 741 HIS A 220 794 GLN C Protein S 17 FT #SUB 167 741 HIS A 223 797 ARG C Protein S 1 FT #HET 82 656 HIS A 3 1003 9GJ A S 3 FT #HET 86 660 HIS A 1 1001 ZN A S 3 FT #HET 122 696 HIS A 1 1001 ZN A S 3 FT #HET 123 697 ASP A 1 1001 ZN A S 3 FT #HET 123 697 ASP A 2 1002 MG A S 3 FT #HET 194 768 THR A 3 1003 9GJ A B 2 FT #HET 196 770 LEU A 3 1003 9GJ A A 9 FT #HET 199 773 HIS A 3 1003 9GJ A S 3 FT #HET 231 805 THR A 3 1003 9GJ A A 5 FT #HET 234 808 ASP A 1 1001 ZN A S 3 FT #HET 234 808 ASP A 3 1003 9GJ A S 2 FT #HET 235 809 LEU A 3 1003 9GJ A S 6 FT #HET 238 812 GLN A 3 1003 9GJ A S 3 FT #HET 249 823 ALA A 3 1003 9GJ A A 3 FT #HET 252 826 ILE A 3 1003 9GJ A S 6 FT #HET 253 827 TYR A 3 1003 9GJ A S 2 FT #HET 256 830 PHE A 3 1003 9GJ A S 3 FT #HET 273 847 MET A 3 1003 9GJ A S 2 FT #HET 284 858 LEU A 3 1003 9GJ A A 2 FT #HET 285 859 GLN A 3 1003 9GJ A S 11 FT #HET 288 862 PHE A 3 1003 9GJ A S 27 FT #HET 292 866 ILE A 3 1003 9GJ A S 2 FT #HET 296 870 ILE A 3 1003 9GJ A S 1 FT DISORDER 1 8 FT DISORDER 343 345 CC SEQUENCE 334 AA (ATOM); CC TKLLHDGIQP VAAIDSNFAS FTYTPRSLPE DDTSMAILSM LQDMNFINNY KIDCPTLARF CC CLMVKKGYRD PPYHNWMHAF SVSHFCYLLY KNLELTNYLE DIEIFALFIS CMCHDLDHRG CC TNNSFQVASK SVLAALYSSE GSVMERHHFA QAIAILNTHG CNIFDHFSRK DYQRMLDLMR CC DIILATDLAH HLRIFKDLQK MAEVGYDRNN KQHHRLLLCL LMTSCDLSDQ TKGWKTTRKI CC AELIYKEFFS QGDLEKAMGN RPMEMMDREK AYIPELQISF MEHIAMPIYK LLQDLFPKAA CC ELYERVASNR EHWTKVSHKF TIRGLPSNNS LDFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ATOM --------TKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ****************************************** CC SEQRES DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ATOM DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ************************************************** CC SEQRES LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ATOM LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ************************************************** CC SEQRES VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ATOM VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ************************************************** CC SEQRES RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ATOM RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ************************************************** CC SEQRES LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ATOM LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ************************************************** CC SEQRES QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEE CC ATOM QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL--- CC ****************************************** SQ SEQUENCE 345 AA; MW; CN; GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FLDEE // ID 5VP0B STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 5VP0 DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.213 FT #SUB 138 712 LYS B 177 751 ARG A Protein S 4 FT #SUB 138 712 LYS B 181 755 GLN A Protein S 7 FT #SUB 140 714 VAL B 161 735 ILE A Protein S 1 FT #SUB 140 714 VAL B 165 739 ASN A Protein S 3 FT #SUB 142 716 ALA B 188 762 ARG A Protein B 1 FT #SUB 143 717 ALA B 157 731 PHE A Protein B 1 FT #SUB 143 717 ALA B 184 758 LEU A Protein S 1 FT #SUB 143 717 ALA B 188 762 ARG A Protein B 5 FT #SUB 144 718 LEU B 158 732 ALA A Protein S 2 FT #SUB 146 720 SER B 188 762 ARG A Protein S 1 FT #SUB 147 721 SER B 188 762 ARG A Protein S 2 FT #SUB 148 722 GLU B 148 722 GLU A Protein S 8 FT #SUB 148 722 GLU B 154 728 ARG A Protein S 3 FT #SUB 154 728 ARG B 148 722 GLU A Protein S 2 FT #SUB 157 731 PHE B 143 717 ALA A Protein S 1 FT #SUB 158 732 ALA B 144 718 LEU A Protein B 1 FT #SUB 161 735 ILE B 140 714 VAL A Protein S 1 FT #SUB 165 739 ASN B 140 714 VAL A Protein S 3 FT #SUB 177 751 ARG B 137 711 SER A Protein S 3 FT #SUB 177 751 ARG B 138 712 LYS A Protein S 5 FT #SUB 177 751 ARG B 266 840 MET A Protein S 1 FT #SUB 181 755 GLN B 138 712 LYS A Protein S 5 FT #SUB 184 758 LEU B 143 717 ALA A Protein S 1 FT #SUB 188 762 ARG B 143 717 ALA A Protein S 1 FT #SUB 266 840 MET B 177 751 ARG A Protein A 2 FT #SUB 77 651 ARG B 212 786 VAL C Protein S 3 FT #SUB 262 836 LEU B 211 785 GLU C Protein S 2 FT #HET 81 655 TYR B 6 1003 9GJ B S 1 FT #HET 82 656 HIS B 6 1003 9GJ B S 1 FT #HET 86 660 HIS B 4 1001 ZN B S 3 FT #HET 122 696 HIS B 4 1001 ZN B S 3 FT #HET 123 697 ASP B 4 1001 ZN B S 3 FT #HET 123 697 ASP B 5 1002 MG B S 3 FT #HET 153 727 GLU B 5 1002 MG B S 1 FT #HET 194 768 THR B 6 1003 9GJ B B 3 FT #HET 196 770 LEU B 6 1003 9GJ B A 10 FT #HET 199 773 HIS B 6 1003 9GJ B S 2 FT #HET 231 805 THR B 6 1003 9GJ B A 5 FT #HET 234 808 ASP B 4 1001 ZN B S 3 FT #HET 234 808 ASP B 6 1003 9GJ B S 2 FT #HET 235 809 LEU B 6 1003 9GJ B S 5 FT #HET 238 812 GLN B 6 1003 9GJ B S 3 FT #HET 249 823 ALA B 6 1003 9GJ B A 3 FT #HET 252 826 ILE B 6 1003 9GJ B S 6 FT #HET 253 827 TYR B 6 1003 9GJ B S 2 FT #HET 256 830 PHE B 6 1003 9GJ B S 6 FT #HET 273 847 MET B 6 1003 9GJ B S 2 FT #HET 284 858 LEU B 6 1003 9GJ B A 2 FT #HET 285 859 GLN B 6 1003 9GJ B S 11 FT #HET 288 862 PHE B 6 1003 9GJ B S 25 FT #HET 292 866 ILE B 6 1003 9GJ B S 2 FT #HET 296 870 ILE B 6 1003 9GJ B S 1 FT DISORDER 1 3 FT DISORDER 343 345 CC SEQUENCE 339 AA (ATOM); CC SDDEYTKLLH DGIQPVAAID SNFASFTYTP RSLPEDDTSM AILSMLQDMN FINNYKIDCP CC TLARFCLMVK KGYRDPPYHN WMHAFSVSHF CYLLYKNLEL TNYLEDIEIF ALFISCMCHD CC LDHRGTNNSF QVASKSVLAA LYSSEGSVME RHHFAQAIAI LNTHGCNIFD HFSRKDYQRM CC LDLMRDIILA TDLAHHLRIF KDLQKMAEVG YDRNNKQHHR LLLCLLMTSC DLSDQTKGWK CC TTRKIAELIY KEFFSQGDLE KAMGNRPMEM MDREKAYIPE LQISFMEHIA MPIYKLLQDL CC FPKAAELYER VASNREHWTK VSHKFTIRGL PSNNSLDFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ATOM ---SDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC *********************************************** CC SEQRES DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ATOM DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ************************************************** CC SEQRES LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ATOM LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ************************************************** CC SEQRES VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ATOM VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ************************************************** CC SEQRES RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ATOM RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ************************************************** CC SEQRES LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ATOM LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ************************************************** CC SEQRES QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEE CC ATOM QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL--- CC ****************************************** SQ SEQUENCE 345 AA; MW; CN; GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FLDEE // ID 5VP0C STANDARD; PRT; 345 AA. DT CONVERTED FROM PDB (SEQRES) 5VP0 DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.213 FT #SUB 220 794 GLN C 167 741 HIS A Protein S 17 FT #SUB 223 797 ARG C 167 741 HIS A Protein S 1 FT #SUB 211 785 GLU C 262 836 LEU B Protein S 2 FT #SUB 212 786 VAL C 77 651 ARG B Protein B 3 FT #HET 81 655 TYR C 9 1003 9GJ C S 1 FT #HET 82 656 HIS C 9 1003 9GJ C S 1 FT #HET 86 660 HIS C 7 1001 ZN C S 3 FT #HET 122 696 HIS C 7 1001 ZN C S 3 FT #HET 123 697 ASP C 7 1001 ZN C S 3 FT #HET 123 697 ASP C 8 1002 MG C S 3 FT #HET 153 727 GLU C 8 1002 MG C S 1 FT #HET 156 730 HIS C 8 1002 MG C S 1 FT #HET 194 768 THR C 9 1003 9GJ C B 3 FT #HET 196 770 LEU C 9 1003 9GJ C A 9 FT #HET 199 773 HIS C 9 1003 9GJ C S 2 FT #HET 231 805 THR C 9 1003 9GJ C A 5 FT #HET 234 808 ASP C 7 1001 ZN C S 3 FT #HET 234 808 ASP C 9 1003 9GJ C S 2 FT #HET 235 809 LEU C 9 1003 9GJ C S 4 FT #HET 238 812 GLN C 9 1003 9GJ C S 3 FT #HET 249 823 ALA C 9 1003 9GJ C B 1 FT #HET 252 826 ILE C 9 1003 9GJ C S 6 FT #HET 253 827 TYR C 9 1003 9GJ C S 2 FT #HET 256 830 PHE C 9 1003 9GJ C S 6 FT #HET 273 847 MET C 9 1003 9GJ C S 2 FT #HET 284 858 LEU C 9 1003 9GJ C A 2 FT #HET 285 859 GLN C 9 1003 9GJ C S 11 FT #HET 288 862 PHE C 9 1003 9GJ C S 20 FT #HET 292 866 ILE C 9 1003 9GJ C S 2 FT #HET 296 870 ILE C 9 1003 9GJ C S 1 FT DISORDER 1 15 FT DISORDER 133 148 FT DISORDER 343 345 CC SEQUENCE 311 AA (ATOM); CC IQPVAAIDSN FASFTYTPRS LPEDDTSMAI LSMLQDMNFI NNYKIDCPTL ARFCLMVKKG CC YRDPPYHNWM HAFSVSHFCY LLYKNLELTN YLEDIEIFAL FISCMCHDLD HRGTNNSGSV CC MERHHFAQAI AILNTHGCNI FDHFSRKDYQ RMLDLMRDII LATDLAHHLR IFKDLQKMAE CC VGYDRNNKQH HRLLLCLLMT SCDLSDQTKG WKTTRKIAEL IYKEFFSQGD LEKAMGNRPM CC EMMDREKAYI PELQISFMEH IAMPIYKLLQ DLFPKAAELY ERVASNREHW TKVSHKFTIR CC GLPSNNSLDF L CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GHASDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC ATOM ---------------IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQ CC *********************************** CC SEQRES DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ATOM DMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKN CC ************************************************** CC SEQRES LELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGS CC ATOM LELTNYLEDIEIFALFISCMCHDLDHRGTNNS----------------GS CC ******************************** ** CC SEQRES VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ATOM VMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHL CC ************************************************** CC SEQRES RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ATOM RIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAE CC ************************************************** CC SEQRES LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ATOM LIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL CC ************************************************** CC SEQRES QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEE CC ATOM QDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL--- CC ****************************************** SQ SEQUENCE 345 AA; MW; CN; GHASDDEYTK LLHDGIQPVA AIDSNFASFT YTPRSLPEDD TSMAILSMLQ DMNFINNYKI DCPTLARFCL MVKKGYRDPP YHNWMHAFSV SHFCYLLYKN LELTNYLEDI EIFALFISCM CHDLDHRGTN NSFQVASKSV LAALYSSEGS VMERHHFAQA IAILNTHGCN IFDHFSRKDY QRMLDLMRDI ILATDLAHHL RIFKDLQKMA EVGYDRNNKQ HHRLLLCLLM TSCDLSDQTK GWKTTRKIAE LIYKEFFSQG DLEKAMGNRP MEMMDREKAY IPELQISFME HIAMPIYKLL QDLFPKAAEL YERVASNREH WTKVSHKFTI RGLPSNNSLD FLDEE //