Brand  (β version)

PDB ID: 5LWM

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Ligands
Code Name Style Show Link
79T 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{N},~{N}-dimethyl-prop-2-enamide PoSSuM
EDO 1,2-ethanediol PoSSuM
PHU 1-phenylurea PoSSuM
Non-standard Residues
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Structure summary

Code : 5LWM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of JAK3 in complex with Compound 4 (FM381)
Release Data : 2016-10-26
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK3 A Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK
ec: 2.7.10.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK3
expression_system_common: Fall armyworm
Authors : Chaikuad, A., Forster, M., Mukhopadhyay, S., Kupinska, K., Ellis, K., Mahajan, P., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Laufer, S.A., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : Transferase, Kinase, JAK3, covalent inhibitor, reversible covalent inhibitor, induced pocket, arginine pocket, Structural Genomics, Structural Genomics Consortium, SGC
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.

Forster, M.,Chaikuad, A.,Bauer, S.M.  et al.
(2016)  Cell Chem Biol  23 : 1335 - 1340

PubMed: 27840070
DOI: 10.1016/j.chembiol.2016.10.008

Reaction

Chain : A
UniProt : P52333 (JAK3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028
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