Brand  (β version)

PDB ID: 5ISO

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Ligands
Code Name Style Show Link
STU Staurosporine PoSSuM
992 5-[[6-chloranyl-5-(1-methylindol-5-yl)-1h-benzimidazol-2-yl]oxy]-2-methyl-benzoic acid PoSSuM
AMP Adenosine monophosphate PoSSuM
Non-standard Residues
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SEP Phosphoserine
Glycosylation
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Modification
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Structure summary

Code : 5ISO   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
Release Data : 2017-03-29
Compound :
mol_id molecule chains synonym
1 5'-AMP-activated protein kinase catalytic subunit alpha-2 A,C AMPK subunit alpha-2,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase
ec: 2.7.11.1,2.7.11.27,2.7.11.31
mol_id molecule chains synonym
2 5'-AMP-activated protein kinase subunit beta-1 B,D AMPKb
other_details: B 108 SER is phosphorylated, and renamed to SEP. THE 16 RESIDUES (MGLNDIFEAQKIEWHE) AT THE N-TERMINAL OF BETA-1 ARE EXPRESSION TAG
mol_id molecule chains synonym
3 5'-AMP-activated protein kinase subunit gamma-1 E,F AMPKg
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PRKAA2, AMPK, AMPK2
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PRKAB1, AMPK
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PRKAG1
Authors : Xiao, B., Hubbard, J.A., Gamblin, S.J.
Keywords : TRANSFERASE, NUCLEOTIDE-BINDING, ACTIVATOR, NON-PHOSPHORYLATION
Exp. method : X-RAY DIFFRACTION ( 2.630 Å )
Citation :

STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)

Xiao, B.,Hubbard, J.A.,Gamblin, S.J.
To Be Published 

Reaction

Chain : A, C
UniProt : P54646 (AAPK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:28552616, PubMed:32029622, PubMed:36732624, PubMed:37079666
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 UniProtKB:Q09137
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ATP + L-seryl-[acetyl-CoA carboxylase] = ADP + H(+) + O- phospho-L-seryl-[acetyl-CoA carboxylase] - UniProtKB:Q09137
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ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] = ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3- methylglutaryl-coenzyme A reductase] 2.7.11.31 UniProtKB:Q09137
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Chain : B, D
UniProt : Q9Y478 (AAKB1_HUMAN)
Reaction : -
Chain : E, F
UniProt : P54619 (AAKG1_HUMAN)
Reaction : -