ID 5ISOA STANDARD; PRT; 552 AA. DT CONVERTED FROM PDB (SEQRES) 5ISO DE 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.630 CC R-Factor 0.180 FT #SUB 9 9 GLY A 122 106 THR B Protein B 2 FT #SUB 11 11 VAL A 122 106 THR B Protein S 2 FT #SUB 11 11 VAL A 129 113 VAL B Protein S 2 FT #SUB 11 11 VAL A 131 115 ILE B Protein S 2 FT #SUB 12 12 LYS A 131 115 ILE B Protein B 3 FT #SUB 13 13 ILE A 95 79 PRO B Protein S 2 FT #SUB 21 21 THR A 124 108 SEP B Protein S 1 FT #SUB 29 29 LYS A 124 108 SEP B Protein S 3 FT #SUB 29 29 LYS A 127 111 ASN B Protein S 1 FT #SUB 31 31 LYS A 124 108 SEP B Protein S 4 FT #SUB 49 49 ARG A 175 159 ASP B Protein S 6 FT #SUB 49 49 ARG A 181 165 ALA B Protein S 6 FT #SUB 49 49 ARG A 185 169 ASP B Protein S 10 FT #SUB 53 53 ARG A 185 169 ASP B Protein S 8 FT #SUB 53 53 ARG A 189 173 CYS B Protein A 3 FT #SUB 56 56 ASP A 189 173 CYS B Protein S 2 FT #SUB 58 58 VAL A 182 166 LEU B Protein S 1 FT #SUB 58 58 VAL A 185 169 ASP B Protein S 1 FT #SUB 58 58 VAL A 186 170 SER B Protein S 3 FT #SUB 58 58 VAL A 189 173 CYS B Protein S 1 FT #SUB 62 62 LYS A 182 166 LEU B Protein A 2 FT #SUB 66 66 GLN A 179 163 PHE B Protein S 2 FT #SUB 82 82 VAL A 178 162 VAL B Protein S 1 FT #SUB 84 84 SER A 175 159 ASP B Protein A 6 FT #SUB 84 84 SER A 176 160 PHE B Protein A 3 FT #SUB 84 84 SER A 178 162 VAL B Protein S 3 FT #SUB 84 84 SER A 181 165 ALA B Protein S 1 FT #SUB 85 85 THR A 95 79 PRO B Protein A 4 FT #SUB 85 85 THR A 175 159 ASP B Protein B 4 FT #SUB 86 86 PRO A 95 79 PRO B Protein S 1 FT #SUB 86 86 PRO A 175 159 ASP B Protein A 11 FT #SUB 86 86 PRO A 176 160 PHE B Protein S 1 FT #SUB 87 87 THR A 97 81 VAL B Protein S 1 FT #SUB 88 88 ASP A 97 81 VAL B Protein S 2 FT #SUB 89 89 PHE A 178 162 VAL B Protein S 2 FT #SUB 89 89 PHE A 181 165 ALA B Protein S 2 FT #SUB 89 89 PHE A 182 166 LEU B Protein S 3 FT #SUB 90 90 PHE A 97 81 VAL B Protein S 1 FT #SUB 164 164 MET A 249 233 HIS B Protein S 2 FT #SUB 165 165 SER A 249 233 HIS B Protein B 1 FT #SUB 166 166 ASP A 249 233 HIS B Protein B 2 FT #SUB 166 166 ASP A 252 236 LEU B Protein S 4 FT #SUB 166 166 ASP A 253 237 ASN B Protein B 1 FT #SUB 166 166 ASP A 272 256 ARG B Protein S 11 FT #SUB 167 167 GLY A 249 233 HIS B Protein B 2 FT #SUB 167 167 GLY A 250 234 VAL B Protein B 5 FT #SUB 167 167 GLY A 252 236 LEU B Protein B 2 FT #SUB 167 167 GLY A 254 238 HIS B Protein B 4 FT #SUB 168 168 GLU A 250 234 VAL B Protein B 2 FT #SUB 169 169 PHE A 223 207 PRO B Protein S 7 FT #SUB 169 169 PHE A 226 210 LEU B Protein S 3 FT #SUB 169 169 PHE A 250 234 VAL B Protein S 6 FT #SUB 171 171 ARG A 220 204 PRO B Protein S 2 FT #SUB 188 188 ARG A 221 205 ILE B Protein S 5 FT #SUB 189 189 LEU A 221 205 ILE B Protein S 1 FT #SUB 191 191 ALA A 225 209 HIS B Protein S 1 FT #SUB 191 191 ALA A 249 233 HIS B Protein B 2 FT #SUB 194 194 GLU A 225 209 HIS B Protein S 4 FT #SUB 254 254 LEU A 224 208 PRO B Protein S 1 FT #SUB 254 254 LEU A 228 212 GLN B Protein S 1 FT #SUB 339 339 GLU A 243 227 LEU B Protein B 1 FT #SUB 341 341 TYR A 276 260 LYS B Protein S 2 FT #SUB 342 342 LEU A 243 227 LEU B Protein B 2 FT #SUB 342 342 LEU A 244 228 LEU B Protein S 1 FT #SUB 342 342 LEU A 246 230 GLU B Protein S 1 FT #SUB 343 343 ALA A 235 219 THR B Protein S 1 FT #SUB 343 343 ALA A 243 227 LEU B Protein A 5 FT #SUB 343 343 ALA A 244 228 LEU B Protein A 7 FT #SUB 343 343 ALA A 245 229 PRO B Protein S 1 FT #SUB 344 344 SER A 235 219 THR B Protein B 1 FT #SUB 344 344 SER A 236 220 GLY B Protein A 3 FT #SUB 346 346 PRO A 234 218 ASP B Protein S 1 FT #SUB 363 363 LEU A 237 221 ILE B Protein B 1 FT #SUB 364 364 LYS A 238 222 SER B Protein B 2 FT #SUB 365 365 PRO A 237 221 ILE B Protein A 6 FT #SUB 366 366 HIS A 237 221 ILE B Protein A 3 FT #SUB 366 366 HIS A 238 222 SER B Protein A 6 FT #SUB 366 366 HIS A 239 223 CYS B Protein S 5 FT #SUB 366 366 HIS A 240 224 ASP B Protein S 2 FT #SUB 366 366 HIS A 241 225 PRO B Protein S 1 FT #SUB 368 368 GLU A 241 225 PRO B Protein B 1 FT #SUB 369 369 ARG A 235 219 THR B Protein S 6 FT #SUB 369 369 ARG A 236 220 GLY B Protein S 3 FT #SUB 369 369 ARG A 237 221 ILE B Protein S 7 FT #SUB 369 369 ARG A 239 223 CYS B Protein S 3 FT #SUB 401 401 LYS A 232 216 ASN B Protein A 6 FT #SUB 401 401 LYS A 258 242 LEU B Protein B 2 FT #SUB 402 402 TRP A 229 213 VAL B Protein A 3 FT #SUB 402 402 TRP A 231 215 LEU B Protein S 5 FT #SUB 402 402 TRP A 232 216 ASN B Protein A 9 FT #SUB 402 402 TRP A 256 240 TYR B Protein S 2 FT #SUB 402 402 TRP A 257 241 ALA B Protein A 10 FT #SUB 402 402 TRP A 258 242 LEU B Protein A 15 FT #SUB 402 402 TRP A 266 250 VAL B Protein S 2 FT #SUB 402 402 TRP A 267 251 LEU B Protein S 1 FT #SUB 402 402 TRP A 268 252 SER B Protein S 5 FT #SUB 402 402 TRP A 281 265 LEU B Protein S 3 FT #SUB 403 403 HIS A 256 240 TYR B Protein B 5 FT #SUB 403 403 HIS A 257 241 ALA B Protein A 9 FT #SUB 403 403 HIS A 258 242 LEU B Protein S 1 FT #SUB 403 403 HIS A 259 243 SER B Protein S 2 FT #SUB 404 404 LEU A 226 210 LEU B Protein S 2 FT #SUB 404 404 LEU A 255 239 LEU B Protein A 2 FT #SUB 404 404 LEU A 256 240 TYR B Protein A 3 FT #SUB 405 405 GLY A 255 239 LEU B Protein B 2 FT #SUB 412 412 PRO A 219 203 PRO B Protein S 1 FT #SUB 420 420 TYR A 207 191 PRO B Protein S 5 FT #SUB 420 420 TYR A 208 192 TYR B Protein S 4 FT #SUB 424 424 LYS A 205 189 GLN B Protein S 5 FT #SUB 429 429 GLU A 203 187 TYR B Protein A 4 FT #SUB 429 429 GLU A 204 188 HIS B Protein B 1 FT #SUB 430 430 TRP A 203 187 TYR B Protein B 5 FT #SUB 430 430 TRP A 204 188 HIS B Protein A 18 FT #SUB 430 430 TRP A 205 189 GLN B Protein S 3 FT #SUB 430 430 TRP A 206 190 GLU B Protein S 5 FT #SUB 430 430 TRP A 207 191 PRO B Protein S 3 FT #SUB 431 431 LYS A 201 185 GLY B Protein S 4 FT #SUB 431 431 LYS A 202 186 PRO B Protein S 2 FT #SUB 431 431 LYS A 203 187 TYR B Protein S 9 FT #SUB 432 432 VAL A 208 192 TYR B Protein S 1 FT #SUB 436 436 TYR A 217 201 ARG B Protein S 3 FT #SUB 436 436 TYR A 218 202 ALA B Protein S 2 FT #SUB 436 436 TYR A 219 203 PRO B Protein S 9 FT #SUB 439 439 ARG A 203 187 TYR B Protein A 4 FT #SUB 441 441 ARG A 203 187 TYR B Protein S 7 FT #SUB 452 452 LYS A 203 187 TYR B Protein S 4 FT #SUB 456 456 GLN A 220 204 PRO B Protein S 2 FT #SUB 457 457 LEU A 219 203 PRO B Protein A 2 FT #SUB 457 457 LEU A 220 204 PRO B Protein B 1 FT #SUB 458 458 TYR A 220 204 PRO B Protein A 5 FT #SUB 458 458 TYR A 221 205 ILE B Protein S 2 FT #SUB 458 458 TYR A 222 206 LEU B Protein S 7 FT #SUB 458 458 TYR A 223 207 PRO B Protein S 2 FT #SUB 459 459 LEU A 220 204 PRO B Protein B 2 FT #SUB 459 459 LEU A 221 205 ILE B Protein B 3 FT #SUB 459 459 LEU A 222 206 LEU B Protein B 4 FT #SUB 460 460 VAL A 222 206 LEU B Protein S 1 FT #SUB 465 465 TYR A 219 203 PRO B Protein S 3 FT #SUB 468 468 ASP A 254 238 HIS B Protein S 8 FT #SUB 469 469 PHE A 253 237 ASN B Protein B 1 FT #SUB 469 469 PHE A 254 238 HIS B Protein B 2 FT #SUB 469 469 PHE A 255 239 LEU B Protein A 7 FT #SUB 470 470 LYS A 253 237 ASN B Protein A 4 FT #SUB 470 470 LYS A 254 238 HIS B Protein S 1 FT #SUB 471 471 SER A 253 237 ASN B Protein A 6 FT #SUB 471 471 SER A 271 255 HIS B Protein S 3 FT #SUB 536 536 THR A 271 255 HIS B Protein S 2 FT #SUB 537 537 MET A 280 264 THR B Protein S 1 FT #SUB 539 539 PHE A 253 237 ASN B Protein S 2 FT #SUB 540 540 PHE A 267 251 LEU B Protein A 2 FT #SUB 540 540 PHE A 268 252 SER B Protein S 4 FT #SUB 540 540 PHE A 269 253 ALA B Protein S 3 FT #SUB 540 540 PHE A 280 264 THR B Protein S 4 FT #SUB 540 540 PHE A 282 266 LEU B Protein S 2 FT #SUB 541 541 GLU A 284 268 LYS B Protein A 3 FT #SUB 543 543 CYS A 255 239 LEU B Protein S 2 FT #SUB 544 544 ALA A 265 249 MET B Protein A 2 FT #SUB 544 544 ALA A 267 251 LEU B Protein S 1 FT #SUB 544 544 ALA A 284 268 LYS B Protein S 2 FT #SUB 547 547 ILE A 255 239 LEU B Protein S 1 FT #SUB 547 547 ILE A 265 249 MET B Protein S 2 FT #SUB 548 548 THR A 286 270 ILE B Protein S 1 FT #SUB 330 330 ASN A 36 36 HIS E Protein S 1 FT #SUB 330 330 ASN A 179 179 PHE E Protein S 1 FT #SUB 333 333 ILE A 178 178 LEU E Protein S 3 FT #SUB 333 333 ILE A 179 179 PHE E Protein S 3 FT #SUB 333 333 ILE A 182 182 GLU E Protein S 4 FT #SUB 340 340 PHE A 171 171 ARG E Protein A 21 FT #SUB 340 340 PHE A 174 174 LYS E Protein S 6 FT #SUB 341 341 TYR A 40 40 ASP E Protein S 4 FT #SUB 341 341 TYR A 42 42 ILE E Protein S 2 FT #SUB 341 341 TYR A 43 43 PRO E Protein A 4 FT #SUB 341 341 TYR A 44 44 THR E Protein A 7 FT #SUB 341 341 TYR A 45 45 SER E Protein B 1 FT #SUB 341 341 TYR A 175 175 PHE E Protein S 2 FT #SUB 342 342 LEU A 44 44 THR E Protein S 1 FT #SUB 342 342 LEU A 45 45 SER E Protein S 2 FT #SUB 364 364 LYS A 294 294 GLU E Protein S 3 FT #SUB 366 366 HIS A 296 296 GLU E Protein S 6 FT #SUB 367 367 PRO A 244 244 PHE E Protein B 2 FT #SUB 367 367 PRO A 295 295 ALA E Protein S 1 FT #SUB 367 367 PRO A 296 296 GLU E Protein S 1 FT #SUB 368 368 GLU A 70 70 ARG E Protein S 6 FT #SUB 368 368 GLU A 170 170 LYS E Protein S 4 FT #SUB 368 368 GLU A 244 244 PHE E Protein B 6 FT #SUB 369 369 ARG A 244 244 PHE E Protein B 1 FT #SUB 370 370 MET A 64 64 LEU E Protein S 1 FT #SUB 370 370 MET A 65 65 VAL E Protein S 1 FT #SUB 370 370 MET A 68 68 GLY E Protein S 3 FT #SUB 370 370 MET A 69 69 VAL E Protein S 1 FT #SUB 370 370 MET A 244 244 PHE E Protein S 2 FT #SUB 370 370 MET A 247 247 ILE E Protein S 3 FT #SUB 371 371 PRO A 65 65 VAL E Protein B 1 FT #SUB 371 371 PRO A 248 248 ASN E Protein S 2 FT #SUB 371 371 PRO A 251 251 ALA E Protein S 1 FT #SUB 372 372 PRO A 251 251 ALA E Protein B 2 FT #SUB 373 373 LEU A 65 65 VAL E Protein B 1 FT #SUB 373 373 LEU A 66 66 THR E Protein S 2 FT #SUB 373 373 LEU A 250 250 ALA E Protein S 1 FT #SUB 373 373 LEU A 251 251 ALA E Protein A 4 FT #SUB 373 373 LEU A 253 253 LYS E Protein S 1 FT #SUB 374 374 ILE A 251 251 ALA E Protein A 4 FT #SUB 374 374 ILE A 253 253 LYS E Protein B 2 FT #SUB 375 375 ALA A 253 253 LYS E Protein B 2 FT #SUB 376 376 ASP A 253 253 LYS E Protein B 2 FT #SUB 444 444 ASN A 80 80 GLN E Protein S 4 FT #SUB 446 446 VAL A 78 78 LYS E Protein S 1 FT #SUB 446 446 VAL A 80 80 GLN E Protein S 1 FT #SUB 447 447 THR A 80 80 GLN E Protein S 1 FT #SUB 530 530 PRO A 158 158 PRO E Protein S 4 FT #SUB 531 531 ARG A 159 159 GLU E Protein S 2 FT #SUB 531 531 ARG A 160 160 SER E Protein S 4 FT #SUB 533 533 GLY A 75 75 TRP E Protein B 1 FT #SUB 533 533 GLY A 80 80 GLN E Protein B 2 FT #SUB 533 533 GLY A 161 161 GLY E Protein B 3 FT #SUB 534 534 SER A 75 75 TRP E Protein A 2 FT #SUB 534 534 SER A 160 160 SER E Protein B 2 FT #SUB 534 534 SER A 161 161 GLY E Protein A 4 FT #SUB 534 534 SER A 162 162 ASN E Protein A 6 FT #SUB 535 535 HIS A 160 160 SER E Protein A 2 FT #SUB 535 535 HIS A 162 162 ASN E Protein B 3 FT #SUB 536 536 THR A 162 162 ASN E Protein A 10 FT #SUB 537 537 MET A 75 75 TRP E Protein S 8 FT #SUB 538 538 ASP A 80 80 GLN E Protein S 1 FT #SUB 541 541 GLU A 75 75 TRP E Protein S 4 FT #SUB 541 541 GLU A 77 77 SER E Protein S 2 FT #SUB 541 541 GLU A 80 80 GLN E Protein S 4 FT #SUB 421 421 ARG A 101 85 THR D Protein S 1 FT #SUB 421 421 ARG A 102 86 GLY D Protein S 2 FT #SUB 421 421 ARG A 103 87 GLY D Protein S 3 FT #SUB 421 421 ARG A 126 110 ASN D Protein S 2 FT #SUB 425 425 GLN A 101 85 THR D Protein S 6 FT #SUB 425 425 GLN A 126 110 ASN D Protein S 1 FT #HET 18 18 LEU A 2 602 992 A A 2 FT #HET 22 22 LEU A 1 601 STU A A 4 FT #HET 23 23 GLY A 1 601 STU A B 5 FT #HET 24 24 VAL A 1 601 STU A B 3 FT #HET 25 25 GLY A 1 601 STU A B 2 FT #HET 28 28 GLY A 2 602 992 A B 2 FT #HET 29 29 LYS A 2 602 992 A A 4 FT #HET 30 30 VAL A 1 601 STU A S 4 FT #HET 31 31 LYS A 2 602 992 A S 7 FT #HET 43 43 ALA A 1 601 STU A S 3 FT #HET 45 45 LYS A 1 601 STU A S 2 FT #HET 46 46 ILE A 2 602 992 A A 8 FT #HET 48 48 ASN A 2 602 992 A S 1 FT #HET 51 51 LYS A 2 602 992 A S 10 FT #HET 77 77 ILE A 1 601 STU A S 2 FT #HET 88 88 ASP A 2 602 992 A S 6 FT #HET 90 90 PHE A 2 602 992 A S 1 FT #HET 93 93 MET A 1 601 STU A S 1 FT #HET 94 94 GLU A 1 601 STU A B 5 FT #HET 95 95 TYR A 1 601 STU A A 6 FT #HET 96 96 VAL A 1 601 STU A A 7 FT #HET 100 100 GLU A 1 601 STU A S 6 FT #HET 143 143 GLU A 1 601 STU A A 8 FT #HET 144 144 ASN A 1 601 STU A A 3 FT #HET 146 146 LEU A 1 601 STU A S 6 FT #HET 156 156 ALA A 1 601 STU A S 1 FT #HET 157 157 ASP A 1 601 STU A A 8 FT #HET 367 367 PRO A 4 402 AMP E A 3 FT DISORDER 1 8 FT DISORDER 347 362 FT DISORDER 378 396 FT DISORDER 475 529 FT DISORDER 552 552 CC SEQUENCE 453 AA (ATOM); CC GRVKIGHYVL GDTLGVGTFG KVKIGEHQLT GHKVAVKILN RQKIRSLDVV GKIKREIQNL CC KLFRHPHIIK LYQVISTPTD FFMVMEYVSG GELFDYICKH GRVEEMEARR LFQQILSAVD CC YCHRHMVVHR DLKPENVLLD AHMNAKIADF GLSNMMSDGE FLRTSCGSPN YAAPEVISGR CC LYAGPEVDIW SCGVILYALL CGTLPFDDEH VPTLFKKIRG GVFYIPEYLN RSVATLLMHM CC LQVDPLKRAT IKDIREHEWF KQDLPSYLFP EDPSYDANVI DDEAVKEVCE KFECTESEVM CC NSLYSGDPQD QLAVAYHLII DNRRIMNQAS EFYLASSPLK PHPERMPPLI ADSVKKAKWH CC LGIRSQSKPY DIMAEVYRAM KQLDFEWKVV NAYHLRVRRK NPVTGNYVKM SLQLYLVDNR CC SYLLDFKSID DPRLGSHTMD FFEMCASLIT TLA CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ CC ATOM --------GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ CC ****************************************** CC SEQRES KIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE CC ATOM KIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE CC ************************************************** CC SEQRES LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH CC ATOM LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH CC ************************************************** CC SEQRES MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC CC ATOM MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC CC ************************************************** CC SEQRES GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ CC ATOM GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ CC ************************************************** CC SEQRES VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF CC ATOM VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF CC ************************************************** CC SEQRES ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGS CC ATOM ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP---- CC ********************************************** CC SEQRES FMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKA CC ATOM ------------LKPHPERMPPLIADS-------------------VKKA CC *************** **** CC SEQRES KWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNY CC ATOM KWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNY CC ************************************************** CC SEQRES VKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRS CC ATOM VKMSLQLYLVDNRSYLLDFKSIDD-------------------------- CC ************************ CC SEQRES SFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTL CC ATOM -----------------------------PRLGSHTMDFFEMCASLITTL CC ********************* CC SEQRES AR CC ATOM A- CC * SQ SEQUENCE 552 AA; MW; CN; MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEMEARRLF QQILSAVDYC HRHMVVHRDL KPENVLLDAH MNAKIADFGL SNMMSDGEFL RTSCGSPNYA APEVISGRLY AGPEVDIWSC GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS VATLLMHMLQ VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPSGS FMDDSAMHIP PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA KWHLGIRSQS KPYDIMAEVY RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR SGSSTPQRSC SAAGLHRPRS SFDSTTAESH SLSGSLTGSL TGSTLSSVSP RLGSHTMDFF EMCASLITTL AR // ID 5ISOB STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 5ISO DE 5'-AMP-activated protein kinase subunit beta-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.630 CC R-Factor 0.180 FT #SUB 95 79 PRO B 13 13 ILE A Protein S 2 FT #SUB 95 79 PRO B 85 85 THR A Protein A 4 FT #SUB 95 79 PRO B 86 86 PRO A Protein B 1 FT #SUB 97 81 VAL B 87 87 THR A Protein S 1 FT #SUB 97 81 VAL B 88 88 ASP A Protein S 2 FT #SUB 97 81 VAL B 90 90 PHE A Protein S 1 FT #SUB 122 106 THR B 9 9 GLY A Protein S 2 FT #SUB 122 106 THR B 11 11 VAL A Protein S 2 FT #SUB 124 108 SEP B 21 21 THR A Protein S 1 FT #SUB 124 108 SEP B 29 29 LYS A Protein S 3 FT #SUB 124 108 SEP B 31 31 LYS A Protein S 4 FT #SUB 127 111 ASN B 29 29 LYS A Protein S 1 FT #SUB 129 113 VAL B 11 11 VAL A Protein S 2 FT #SUB 131 115 ILE B 11 11 VAL A Protein S 2 FT #SUB 131 115 ILE B 12 12 LYS A Protein S 3 FT #SUB 175 159 ASP B 49 49 ARG A Protein A 6 FT #SUB 175 159 ASP B 84 84 SER A Protein B 6 FT #SUB 175 159 ASP B 85 85 THR A Protein B 4 FT #SUB 175 159 ASP B 86 86 PRO A Protein S 11 FT #SUB 176 160 PHE B 84 84 SER A Protein A 3 FT #SUB 176 160 PHE B 86 86 PRO A Protein S 1 FT #SUB 178 162 VAL B 82 82 VAL A Protein S 1 FT #SUB 178 162 VAL B 84 84 SER A Protein B 3 FT #SUB 178 162 VAL B 89 89 PHE A Protein S 2 FT #SUB 179 163 PHE B 66 66 GLN A Protein S 2 FT #SUB 181 165 ALA B 49 49 ARG A Protein A 6 FT #SUB 181 165 ALA B 84 84 SER A Protein S 1 FT #SUB 181 165 ALA B 89 89 PHE A Protein S 2 FT #SUB 182 166 LEU B 58 58 VAL A Protein B 1 FT #SUB 182 166 LEU B 62 62 LYS A Protein S 2 FT #SUB 182 166 LEU B 89 89 PHE A Protein S 3 FT #SUB 185 169 ASP B 49 49 ARG A Protein S 10 FT #SUB 185 169 ASP B 53 53 ARG A Protein A 8 FT #SUB 185 169 ASP B 58 58 VAL A Protein S 1 FT #SUB 186 170 SER B 58 58 VAL A Protein A 3 FT #SUB 189 173 CYS B 53 53 ARG A Protein S 3 FT #SUB 189 173 CYS B 56 56 ASP A Protein S 2 FT #SUB 189 173 CYS B 58 58 VAL A Protein S 1 FT #SUB 201 185 GLY B 431 431 LYS A Protein B 4 FT #SUB 202 186 PRO B 431 431 LYS A Protein B 2 FT #SUB 203 187 TYR B 429 429 GLU A Protein A 4 FT #SUB 203 187 TYR B 430 430 TRP A Protein A 5 FT #SUB 203 187 TYR B 431 431 LYS A Protein S 9 FT #SUB 203 187 TYR B 439 439 ARG A Protein S 4 FT #SUB 203 187 TYR B 441 441 ARG A Protein S 7 FT #SUB 203 187 TYR B 452 452 LYS A Protein S 4 FT #SUB 204 188 HIS B 429 429 GLU A Protein B 1 FT #SUB 204 188 HIS B 430 430 TRP A Protein A 18 FT #SUB 205 189 GLN B 424 424 LYS A Protein S 5 FT #SUB 205 189 GLN B 430 430 TRP A Protein B 3 FT #SUB 206 190 GLU B 430 430 TRP A Protein B 5 FT #SUB 207 191 PRO B 420 420 TYR A Protein A 5 FT #SUB 207 191 PRO B 430 430 TRP A Protein B 3 FT #SUB 208 192 TYR B 420 420 TYR A Protein A 4 FT #SUB 208 192 TYR B 432 432 VAL A Protein S 1 FT #SUB 217 201 ARG B 436 436 TYR A Protein B 3 FT #SUB 218 202 ALA B 436 436 TYR A Protein B 2 FT #SUB 219 203 PRO B 412 412 PRO A Protein S 1 FT #SUB 219 203 PRO B 436 436 TYR A Protein A 9 FT #SUB 219 203 PRO B 457 457 LEU A Protein S 2 FT #SUB 219 203 PRO B 465 465 TYR A Protein S 3 FT #SUB 220 204 PRO B 171 171 ARG A Protein S 2 FT #SUB 220 204 PRO B 456 456 GLN A Protein S 2 FT #SUB 220 204 PRO B 457 457 LEU A Protein S 1 FT #SUB 220 204 PRO B 458 458 TYR A Protein B 5 FT #SUB 220 204 PRO B 459 459 LEU A Protein B 2 FT #SUB 221 205 ILE B 188 188 ARG A Protein S 5 FT #SUB 221 205 ILE B 189 189 LEU A Protein B 1 FT #SUB 221 205 ILE B 458 458 TYR A Protein B 2 FT #SUB 221 205 ILE B 459 459 LEU A Protein A 3 FT #SUB 222 206 LEU B 458 458 TYR A Protein A 7 FT #SUB 222 206 LEU B 459 459 LEU A Protein A 4 FT #SUB 222 206 LEU B 460 460 VAL A Protein S 1 FT #SUB 223 207 PRO B 169 169 PHE A Protein S 7 FT #SUB 223 207 PRO B 458 458 TYR A Protein S 2 FT #SUB 224 208 PRO B 254 254 LEU A Protein S 1 FT #SUB 225 209 HIS B 191 191 ALA A Protein S 1 FT #SUB 225 209 HIS B 194 194 GLU A Protein S 4 FT #SUB 226 210 LEU B 169 169 PHE A Protein S 3 FT #SUB 226 210 LEU B 404 404 LEU A Protein A 2 FT #SUB 228 212 GLN B 254 254 LEU A Protein S 1 FT #SUB 229 213 VAL B 402 402 TRP A Protein S 3 FT #SUB 231 215 LEU B 402 402 TRP A Protein S 5 FT #SUB 232 216 ASN B 401 401 LYS A Protein A 6 FT #SUB 232 216 ASN B 402 402 TRP A Protein S 9 FT #SUB 234 218 ASP B 346 346 PRO A Protein B 1 FT #SUB 235 219 THR B 343 343 ALA A Protein S 1 FT #SUB 235 219 THR B 344 344 SER A Protein B 1 FT #SUB 235 219 THR B 369 369 ARG A Protein A 6 FT #SUB 236 220 GLY B 344 344 SER A Protein B 3 FT #SUB 236 220 GLY B 369 369 ARG A Protein B 3 FT #SUB 237 221 ILE B 363 363 LEU A Protein S 1 FT #SUB 237 221 ILE B 365 365 PRO A Protein A 6 FT #SUB 237 221 ILE B 366 366 HIS A Protein B 3 FT #SUB 237 221 ILE B 369 369 ARG A Protein B 7 FT #SUB 238 222 SER B 364 364 LYS A Protein A 2 FT #SUB 238 222 SER B 366 366 HIS A Protein B 6 FT #SUB 239 223 CYS B 366 366 HIS A Protein B 5 FT #SUB 239 223 CYS B 369 369 ARG A Protein A 3 FT #SUB 240 224 ASP B 366 366 HIS A Protein B 2 FT #SUB 241 225 PRO B 366 366 HIS A Protein S 1 FT #SUB 241 225 PRO B 368 368 GLU A Protein S 1 FT #SUB 243 227 LEU B 339 339 GLU A Protein S 1 FT #SUB 243 227 LEU B 342 342 LEU A Protein S 2 FT #SUB 243 227 LEU B 343 343 ALA A Protein A 5 FT #SUB 244 228 LEU B 342 342 LEU A Protein B 1 FT #SUB 244 228 LEU B 343 343 ALA A Protein B 7 FT #SUB 245 229 PRO B 343 343 ALA A Protein B 1 FT #SUB 246 230 GLU B 342 342 LEU A Protein B 1 FT #SUB 249 233 HIS B 164 164 MET A Protein S 2 FT #SUB 249 233 HIS B 165 165 SER A Protein S 1 FT #SUB 249 233 HIS B 166 166 ASP A Protein B 2 FT #SUB 249 233 HIS B 167 167 GLY A Protein B 2 FT #SUB 249 233 HIS B 191 191 ALA A Protein S 2 FT #SUB 250 234 VAL B 167 167 GLY A Protein B 5 FT #SUB 250 234 VAL B 168 168 GLU A Protein S 2 FT #SUB 250 234 VAL B 169 169 PHE A Protein S 6 FT #SUB 252 236 LEU B 166 166 ASP A Protein S 4 FT #SUB 252 236 LEU B 167 167 GLY A Protein B 2 FT #SUB 253 237 ASN B 166 166 ASP A Protein S 1 FT #SUB 253 237 ASN B 469 469 PHE A Protein B 1 FT #SUB 253 237 ASN B 470 470 LYS A Protein A 4 FT #SUB 253 237 ASN B 471 471 SER A Protein A 6 FT #SUB 253 237 ASN B 539 539 PHE A Protein B 2 FT #SUB 254 238 HIS B 167 167 GLY A Protein S 4 FT #SUB 254 238 HIS B 468 468 ASP A Protein S 8 FT #SUB 254 238 HIS B 469 469 PHE A Protein B 2 FT #SUB 254 238 HIS B 470 470 LYS A Protein S 1 FT #SUB 255 239 LEU B 404 404 LEU A Protein B 2 FT #SUB 255 239 LEU B 405 405 GLY A Protein B 2 FT #SUB 255 239 LEU B 469 469 PHE A Protein A 7 FT #SUB 255 239 LEU B 543 543 CYS A Protein S 2 FT #SUB 255 239 LEU B 547 547 ILE A Protein S 1 FT #SUB 256 240 TYR B 402 402 TRP A Protein B 2 FT #SUB 256 240 TYR B 403 403 HIS A Protein A 5 FT #SUB 256 240 TYR B 404 404 LEU A Protein S 3 FT #SUB 257 241 ALA B 402 402 TRP A Protein B 10 FT #SUB 257 241 ALA B 403 403 HIS A Protein B 9 FT #SUB 258 242 LEU B 401 401 LYS A Protein S 2 FT #SUB 258 242 LEU B 402 402 TRP A Protein A 15 FT #SUB 258 242 LEU B 403 403 HIS A Protein B 1 FT #SUB 259 243 SER B 403 403 HIS A Protein A 2 FT #SUB 265 249 MET B 544 544 ALA A Protein S 2 FT #SUB 265 249 MET B 547 547 ILE A Protein S 2 FT #SUB 266 250 VAL B 402 402 TRP A Protein A 2 FT #SUB 267 251 LEU B 402 402 TRP A Protein B 1 FT #SUB 267 251 LEU B 540 540 PHE A Protein S 2 FT #SUB 267 251 LEU B 544 544 ALA A Protein S 1 FT #SUB 268 252 SER B 402 402 TRP A Protein A 5 FT #SUB 268 252 SER B 540 540 PHE A Protein B 4 FT #SUB 269 253 ALA B 540 540 PHE A Protein A 3 FT #SUB 271 255 HIS B 471 471 SER A Protein S 3 FT #SUB 271 255 HIS B 536 536 THR A Protein S 2 FT #SUB 272 256 ARG B 166 166 ASP A Protein S 11 FT #SUB 276 260 LYS B 341 341 TYR A Protein S 2 FT #SUB 280 264 THR B 537 537 MET A Protein S 1 FT #SUB 280 264 THR B 540 540 PHE A Protein A 4 FT #SUB 281 265 LEU B 402 402 TRP A Protein S 3 FT #SUB 282 266 LEU B 540 540 PHE A Protein S 2 FT #SUB 284 268 LYS B 541 541 GLU A Protein S 3 FT #SUB 284 268 LYS B 544 544 ALA A Protein S 2 FT #SUB 286 270 ILE B 548 548 THR A Protein S 1 FT #SUB 241 225 PRO B 47 47 LYS E Protein B 1 FT #SUB 241 225 PRO B 68 68 GLY E Protein S 2 FT #SUB 242 226 ALA B 46 46 SER E Protein B 3 FT #SUB 242 226 ALA B 47 47 LYS E Protein B 1 FT #SUB 243 227 LEU B 43 43 PRO E Protein S 2 FT #SUB 243 227 LEU B 45 45 SER E Protein B 2 FT #SUB 244 228 LEU B 45 45 SER E Protein A 9 FT #SUB 244 228 LEU B 46 46 SER E Protein S 2 FT #SUB 244 228 LEU B 47 47 LYS E Protein S 2 FT #SUB 245 229 PRO B 45 45 SER E Protein B 4 FT #SUB 247 231 PRO B 45 45 SER E Protein S 1 FT #SUB 262 246 ASP B 59 59 LYS E Protein A 7 FT #SUB 264 248 VAL B 55 55 LEU E Protein S 1 FT #SUB 264 248 VAL B 59 59 LYS E Protein S 2 FT #SUB 273 257 TYR B 39 39 TYR E Protein S 4 FT #SUB 273 257 TYR B 134 134 PRO E Protein S 4 FT #SUB 273 257 TYR B 157 157 ASP E Protein S 6 FT #SUB 273 257 TYR B 159 159 GLU E Protein S 1 FT #SUB 273 257 TYR B 164 164 LEU E Protein S 3 FT #SUB 274 258 LYS B 39 39 TYR E Protein S 5 FT #SUB 275 259 LYS B 39 39 TYR E Protein A 3 FT #SUB 276 260 LYS B 39 39 TYR E Protein S 7 FT #SUB 276 260 LYS B 42 42 ILE E Protein S 4 FT #SUB 276 260 LYS B 43 43 PRO E Protein S 3 FT #SUB 276 260 LYS B 44 44 THR E Protein A 4 FT #SUB 277 261 TYR B 44 44 THR E Protein A 9 FT #SUB 277 261 TYR B 45 45 SER E Protein B 3 FT #SUB 277 261 TYR B 46 46 SER E Protein B 3 FT #SUB 278 262 VAL B 46 46 SER E Protein B 2 FT #SUB 278 262 VAL B 164 164 LEU E Protein S 2 FT #SUB 279 263 THR B 46 46 SER E Protein A 4 FT #SUB 279 263 THR B 47 47 LYS E Protein B 3 FT #SUB 279 263 THR B 48 48 LEU E Protein B 4 FT #SUB 280 264 THR B 48 48 LEU E Protein B 2 FT #SUB 280 264 THR B 50 50 VAL E Protein S 1 FT #SUB 281 265 LEU B 48 48 LEU E Protein A 6 FT #SUB 281 265 LEU B 49 49 VAL E Protein B 2 FT #SUB 281 265 LEU B 50 50 VAL E Protein B 7 FT #SUB 281 265 LEU B 67 67 ASN E Protein S 1 FT #SUB 282 266 LEU B 50 50 VAL E Protein A 5 FT #SUB 283 267 TYR B 50 50 VAL E Protein A 3 FT #SUB 283 267 TYR B 51 51 PHE E Protein S 4 FT #SUB 283 267 TYR B 52 52 ASP E Protein B 3 FT #SUB 283 267 TYR B 55 55 LEU E Protein S 1 FT #SUB 283 267 TYR B 63 63 ALA E Protein S 3 FT #SUB 283 267 TYR B 67 67 ASN E Protein S 5 FT #SUB 285 269 PRO B 54 54 SER E Protein S 4 FT #SUB 285 269 PRO B 55 55 LEU E Protein S 3 FT #SUB 194 178 GLU B 218 218 HIS C Protein S 1 FT #SUB 286 270 ILE B 151 135 HIS D Protein A 3 FT #HET 97 81 VAL B 2 602 992 A S 1 FT #HET 99 83 ARG B 2 602 992 A S 25 FT #HET 122 106 THR B 2 602 992 A A 3 FT #HET 123 107 ARG B 2 602 992 A B 2 FT #HET 124 108 SEP B 2 602 992 A A 4 FT #HET 127 111 ASN B 2 602 992 A S 4 FT #HET 129 113 VAL B 2 602 992 A S 7 FT #HET 131 115 ILE B 2 602 992 A S 1 FT DISORDER 1 92 FT DISORDER 197 200 FT DISORDER 210 216 CC SEQUENCE 183 AA (ATOM); CC ARPTVFRWTG GGKEVYLSGS FNNWSKLPLT RXHNNFVAIL DLPEGEHQYK FFVDGQWTHD CC PSEPIVTSQL GTVNNIIQVK KTDFEVFDAL MVDSQKCSDV SELSGPYHQE PYVRAPPILP CC PHLLQVILNK DTGISCDPAL LPEPNHVMLN HLYALSIKDG VMVLSATHRY KKKYVTTLLY CC KPI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MGLNDIFEAQKIEWHEMGNTSSERAALERHGGHKTPRRDSSGGTKDGDRP CC ATOM -------------------------------------------------- CC CC SEQRES KILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRW CC ATOM ------------------------------------------ARPTVFRW CC ******** CC SEQRES TGGGKEVYLSGSFNNWSKLPLTRXHNNFVAILDLPEGEHQYKFFVDGQWT CC ATOM TGGGKEVYLSGSFNNWSKLPLTRXHNNFVAILDLPEGEHQYKFFVDGQWT CC ************************************************** CC SEQRES HDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPP CC ATOM HDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELS---- CC ********************************************** CC SEQRES GPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHV CC ATOM GPYHQEPYV-------RAPPILPPHLLQVILNKDTGISCDPALLPEPNHV CC ********* ********************************** CC SEQRES MLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI CC ATOM MLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI CC ************************************ SQ SEQUENCE 286 AA; MW; CN; MGLNDIFEAQ KIEWHEMGNT SSERAALERH GGHKTPRRDS SGGTKDGDRP KILMDSPEDA DLFHSEEIKA PEKEEFLAWQ HDLEVNDKAP AQARPTVFRW TGGGKEVYLS GSFNNWSKLP LTRXHNNFVA ILDLPEGEHQ YKFFVDGQWT HDPSEPIVTS QLGTVNNIIQ VKKTDFEVFD ALMVDSQKCS DVSELSSSPP GPYHQEPYVC KPEERFRAPP ILPPHLLQVI LNKDTGISCD PALLPEPNHV MLNHLYALSI KDGVMVLSAT HRYKKKYVTT LLYKPI // ID 5ISOE STANDARD; PRT; 331 AA. DT CONVERTED FROM PDB (SEQRES) 5ISO DE 5'-AMP-activated protein kinase subunit gamma-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.630 CC R-Factor 0.180 FT #SUB 36 36 HIS E 330 330 ASN A Protein S 1 FT #SUB 40 40 ASP E 341 341 TYR A Protein B 4 FT #SUB 42 42 ILE E 341 341 TYR A Protein B 2 FT #SUB 43 43 PRO E 341 341 TYR A Protein A 4 FT #SUB 44 44 THR E 341 341 TYR A Protein A 7 FT #SUB 44 44 THR E 342 342 LEU A Protein S 1 FT #SUB 45 45 SER E 341 341 TYR A Protein B 1 FT #SUB 45 45 SER E 342 342 LEU A Protein A 2 FT #SUB 64 64 LEU E 370 370 MET A Protein B 1 FT #SUB 65 65 VAL E 370 370 MET A Protein B 1 FT #SUB 65 65 VAL E 371 371 PRO A Protein S 1 FT #SUB 65 65 VAL E 373 373 LEU A Protein S 1 FT #SUB 66 66 THR E 373 373 LEU A Protein S 2 FT #SUB 68 68 GLY E 370 370 MET A Protein B 3 FT #SUB 69 69 VAL E 370 370 MET A Protein B 1 FT #SUB 70 70 ARG E 368 368 GLU A Protein S 6 FT #SUB 75 75 TRP E 533 533 GLY A Protein S 1 FT #SUB 75 75 TRP E 534 534 SER A Protein S 2 FT #SUB 75 75 TRP E 537 537 MET A Protein S 8 FT #SUB 75 75 TRP E 541 541 GLU A Protein S 4 FT #SUB 77 77 SER E 541 541 GLU A Protein A 2 FT #SUB 78 78 LYS E 446 446 VAL A Protein B 1 FT #SUB 80 80 GLN E 444 444 ASN A Protein S 4 FT #SUB 80 80 GLN E 446 446 VAL A Protein S 1 FT #SUB 80 80 GLN E 447 447 THR A Protein S 1 FT #SUB 80 80 GLN E 533 533 GLY A Protein B 2 FT #SUB 80 80 GLN E 538 538 ASP A Protein S 1 FT #SUB 80 80 GLN E 541 541 GLU A Protein S 4 FT #SUB 158 158 PRO E 530 530 PRO A Protein A 4 FT #SUB 159 159 GLU E 531 531 ARG A Protein B 2 FT #SUB 160 160 SER E 531 531 ARG A Protein B 4 FT #SUB 160 160 SER E 534 534 SER A Protein B 2 FT #SUB 160 160 SER E 535 535 HIS A Protein B 2 FT #SUB 161 161 GLY E 533 533 GLY A Protein B 3 FT #SUB 161 161 GLY E 534 534 SER A Protein B 4 FT #SUB 162 162 ASN E 534 534 SER A Protein A 6 FT #SUB 162 162 ASN E 535 535 HIS A Protein S 3 FT #SUB 162 162 ASN E 536 536 THR A Protein S 10 FT #SUB 170 170 LYS E 368 368 GLU A Protein S 4 FT #SUB 171 171 ARG E 340 340 PHE A Protein A 21 FT #SUB 174 174 LYS E 340 340 PHE A Protein S 6 FT #SUB 175 175 PHE E 341 341 TYR A Protein S 2 FT #SUB 178 178 LEU E 333 333 ILE A Protein A 3 FT #SUB 179 179 PHE E 330 330 ASN A Protein S 1 FT #SUB 179 179 PHE E 333 333 ILE A Protein S 3 FT #SUB 182 182 GLU E 333 333 ILE A Protein S 4 FT #SUB 244 244 PHE E 367 367 PRO A Protein S 2 FT #SUB 244 244 PHE E 368 368 GLU A Protein S 6 FT #SUB 244 244 PHE E 369 369 ARG A Protein S 1 FT #SUB 244 244 PHE E 370 370 MET A Protein S 2 FT #SUB 247 247 ILE E 370 370 MET A Protein S 3 FT #SUB 248 248 ASN E 371 371 PRO A Protein S 2 FT #SUB 250 250 ALA E 373 373 LEU A Protein B 1 FT #SUB 251 251 ALA E 371 371 PRO A Protein S 1 FT #SUB 251 251 ALA E 372 372 PRO A Protein A 2 FT #SUB 251 251 ALA E 373 373 LEU A Protein B 4 FT #SUB 251 251 ALA E 374 374 ILE A Protein B 4 FT #SUB 253 253 LYS E 373 373 LEU A Protein S 1 FT #SUB 253 253 LYS E 374 374 ILE A Protein S 2 FT #SUB 253 253 LYS E 375 375 ALA A Protein S 2 FT #SUB 253 253 LYS E 376 376 ASP A Protein S 2 FT #SUB 294 294 GLU E 364 364 LYS A Protein S 3 FT #SUB 295 295 ALA E 367 367 PRO A Protein B 1 FT #SUB 296 296 GLU E 366 366 HIS A Protein S 6 FT #SUB 296 296 GLU E 367 367 PRO A Protein B 1 FT #SUB 39 39 TYR E 273 257 TYR B Protein S 4 FT #SUB 39 39 TYR E 274 258 LYS B Protein S 5 FT #SUB 39 39 TYR E 275 259 LYS B Protein S 3 FT #SUB 39 39 TYR E 276 260 LYS B Protein A 7 FT #SUB 42 42 ILE E 276 260 LYS B Protein B 4 FT #SUB 43 43 PRO E 243 227 LEU B Protein S 2 FT #SUB 43 43 PRO E 276 260 LYS B Protein B 3 FT #SUB 44 44 THR E 276 260 LYS B Protein B 4 FT #SUB 44 44 THR E 277 261 TYR B Protein B 9 FT #SUB 45 45 SER E 243 227 LEU B Protein B 2 FT #SUB 45 45 SER E 244 228 LEU B Protein A 9 FT #SUB 45 45 SER E 245 229 PRO B Protein S 4 FT #SUB 45 45 SER E 247 231 PRO B Protein S 1 FT #SUB 45 45 SER E 277 261 TYR B Protein B 3 FT #SUB 46 46 SER E 242 226 ALA B Protein A 3 FT #SUB 46 46 SER E 244 228 LEU B Protein B 2 FT #SUB 46 46 SER E 277 261 TYR B Protein A 3 FT #SUB 46 46 SER E 278 262 VAL B Protein B 2 FT #SUB 46 46 SER E 279 263 THR B Protein B 4 FT #SUB 47 47 LYS E 241 225 PRO B Protein S 1 FT #SUB 47 47 LYS E 242 226 ALA B Protein B 1 FT #SUB 47 47 LYS E 244 228 LEU B Protein A 2 FT #SUB 47 47 LYS E 279 263 THR B Protein A 3 FT #SUB 48 48 LEU E 279 263 THR B Protein B 4 FT #SUB 48 48 LEU E 280 264 THR B Protein B 2 FT #SUB 48 48 LEU E 281 265 LEU B Protein B 6 FT #SUB 49 49 VAL E 281 265 LEU B Protein B 2 FT #SUB 50 50 VAL E 280 264 THR B Protein S 1 FT #SUB 50 50 VAL E 281 265 LEU B Protein A 7 FT #SUB 50 50 VAL E 282 266 LEU B Protein A 5 FT #SUB 50 50 VAL E 283 267 TYR B Protein B 3 FT #SUB 51 51 PHE E 283 267 TYR B Protein S 4 FT #SUB 52 52 ASP E 283 267 TYR B Protein A 3 FT #SUB 54 54 SER E 285 269 PRO B Protein A 4 FT #SUB 55 55 LEU E 264 248 VAL B Protein S 1 FT #SUB 55 55 LEU E 283 267 TYR B Protein S 1 FT #SUB 55 55 LEU E 285 269 PRO B Protein A 3 FT #SUB 59 59 LYS E 262 246 ASP B Protein S 7 FT #SUB 59 59 LYS E 264 248 VAL B Protein S 2 FT #SUB 63 63 ALA E 283 267 TYR B Protein S 3 FT #SUB 67 67 ASN E 281 265 LEU B Protein S 1 FT #SUB 67 67 ASN E 283 267 TYR B Protein S 5 FT #SUB 68 68 GLY E 241 225 PRO B Protein B 2 FT #SUB 134 134 PRO E 273 257 TYR B Protein S 4 FT #SUB 157 157 ASP E 273 257 TYR B Protein S 6 FT #SUB 159 159 GLU E 273 257 TYR B Protein S 1 FT #SUB 164 164 LEU E 273 257 TYR B Protein S 3 FT #SUB 164 164 LEU E 278 262 VAL B Protein B 2 FT #HET 70 70 ARG E 4 402 AMP E S 1 FT #HET 85 85 MET E 3 401 AMP E A 4 FT #HET 87 87 THR E 3 401 AMP E S 6 FT #HET 89 89 THR E 3 401 AMP E S 4 FT #HET 90 90 ASP E 3 401 AMP E A 5 FT #HET 121 121 TYR E 3 401 AMP E S 1 FT #HET 128 128 PRO E 3 401 AMP E B 1 FT #HET 129 129 LEU E 3 401 AMP E A 3 FT #HET 130 130 VAL E 3 401 AMP E A 11 FT #HET 150 150 ILE E 3 401 AMP E A 6 FT #HET 151 151 HIS E 3 401 AMP E A 8 FT #HET 151 151 HIS E 5 403 AMP E S 6 FT #HET 152 152 ARG E 3 401 AMP E A 4 FT #HET 154 154 PRO E 3 401 AMP E S 2 FT #HET 170 170 LYS E 4 402 AMP E S 3 FT #HET 200 200 THR E 5 403 AMP E A 8 FT #HET 203 203 ASN E 5 403 AMP E B 1 FT #HET 204 204 ILE E 5 403 AMP E A 5 FT #HET 205 205 ALA E 5 403 AMP E A 8 FT #HET 225 225 VAL E 5 403 AMP E A 11 FT #HET 226 226 SER E 5 403 AMP E A 7 FT #HET 227 227 ALA E 5 403 AMP E B 2 FT #HET 229 229 PRO E 5 403 AMP E S 1 FT #HET 240 240 ILE E 4 402 AMP E A 8 FT #HET 242 242 SER E 4 402 AMP E S 7 FT #HET 244 244 PHE E 4 402 AMP E S 3 FT #HET 245 245 ASP E 4 402 AMP E S 10 FT #HET 269 269 ARG E 4 402 AMP E S 4 FT #HET 275 275 GLY E 4 402 AMP E B 1 FT #HET 276 276 VAL E 4 402 AMP E A 4 FT #HET 277 277 LEU E 4 402 AMP E A 13 FT #HET 297 297 VAL E 4 402 AMP E A 14 FT #HET 298 298 HIS E 4 402 AMP E A 3 FT #HET 298 298 HIS E 5 403 AMP E S 5 FT #HET 299 299 ARG E 4 402 AMP E A 14 FT #HET 312 312 ILE E 5 403 AMP E A 3 FT #HET 314 314 SER E 5 403 AMP E S 4 FT #HET 316 316 SER E 5 403 AMP E S 5 FT #HET 317 317 ASP E 5 403 AMP E S 12 FT DISORDER 1 26 FT DISORDER 325 331 CC SEQUENCE 298 AA (ATOM); CC SVYTSFMKSH RCYDLIPTSS KLVVFDTSLQ VKKAFFALVT NGVRAAPLWD SKKQSFVGML CC TITDFINILH RYYKSALVQI YELEEHKIET WREVYLQDSF KPLVCISPNA SLFDAVSSLI CC RNKIHRLPVI DPESGNTLYI LTHKRILKFL KLFITEFPKP EFMSKSLEEL QIGTYANIAM CC VRTTTPVYVA LGIFVQHRVS ALPVVDEKGR VVDIYSKFDV INLAAEKTYN NLDVSVTKAL CC QHRSHYFEGV LKCYLHETLE TIINRLVEAE VHRLVVVDEN DVVKGIVSLS DILQALVL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVV CC ATOM --------------------------SVYTSFMKSHRCYDLIPTSSKLVV CC ************************ CC SEQRES FDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYK CC ATOM FDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYK CC ************************************************** CC SEQRES SALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKI CC ATOM SALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKI CC ************************************************** CC SEQRES HRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGT CC ATOM HRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGT CC ************************************************** CC SEQRES YANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLA CC ATOM YANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLA CC ************************************************** CC SEQRES AEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL CC ATOM AEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL CC ************************************************** CC SEQRES VVVDENDVVKGIVSLSDILQALVLTGGEKKP CC ATOM VVVDENDVVKGIVSLSDILQALVL------- CC ************************ SQ SEQUENCE 331 AA; MW; CN; METVISSDSS PAVENEHPQE TPESNNSVYT SFMKSHRCYD LIPTSSKLVV FDTSLQVKKA FFALVTNGVR AAPLWDSKKQ SFVGMLTITD FINILHRYYK SALVQIYELE EHKIETWREV YLQDSFKPLV CISPNASLFD AVSSLIRNKI HRLPVIDPES GNTLYILTHK RILKFLKLFI TEFPKPEFMS KSLEELQIGT YANIAMVRTT TPVYVALGIF VQHRVSALPV VDEKGRVVDI YSKFDVINLA AEKTYNNLDV SVTKALQHRS HYFEGVLKCY LHETLETIIN RLVEAEVHRL VVVDENDVVK GIVSLSDILQ ALVLTGGEKK P // ID 5ISOC STANDARD; PRT; 552 AA. DT CONVERTED FROM PDB (SEQRES) 5ISO DE 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.630 CC R-Factor 0.180 FT #SUB 218 218 HIS C 194 178 GLU B Protein S 1 FT #SUB 9 9 GLY C 122 106 THR D Protein B 1 FT #SUB 11 11 VAL C 122 106 THR D Protein S 1 FT #SUB 11 11 VAL C 129 113 VAL D Protein S 2 FT #SUB 11 11 VAL C 131 115 ILE D Protein S 2 FT #SUB 12 12 LYS C 131 115 ILE D Protein B 3 FT #SUB 21 21 THR C 124 108 SEP D Protein S 1 FT #SUB 29 29 LYS C 124 108 SEP D Protein S 3 FT #SUB 29 29 LYS C 127 111 ASN D Protein S 1 FT #SUB 31 31 LYS C 124 108 SEP D Protein S 5 FT #SUB 48 48 ASN C 99 83 ARG D Protein S 1 FT #SUB 49 49 ARG C 175 159 ASP D Protein S 6 FT #SUB 49 49 ARG C 181 165 ALA D Protein S 4 FT #SUB 49 49 ARG C 185 169 ASP D Protein A 4 FT #SUB 53 53 ARG C 185 169 ASP D Protein S 1 FT #SUB 53 53 ARG C 188 172 LYS D Protein B 1 FT #SUB 56 56 ASP C 188 172 LYS D Protein S 4 FT #SUB 58 58 VAL C 182 166 LEU D Protein A 3 FT #SUB 58 58 VAL C 186 170 SER D Protein S 2 FT #SUB 69 69 LYS C 179 163 PHE D Protein S 1 FT #SUB 84 84 SER C 175 159 ASP D Protein A 6 FT #SUB 84 84 SER C 176 160 PHE D Protein A 3 FT #SUB 84 84 SER C 178 162 VAL D Protein S 2 FT #SUB 84 84 SER C 181 165 ALA D Protein S 1 FT #SUB 85 85 THR C 95 79 PRO D Protein A 4 FT #SUB 85 85 THR C 97 81 VAL D Protein S 1 FT #SUB 85 85 THR C 175 159 ASP D Protein B 4 FT #SUB 86 86 PRO C 95 79 PRO D Protein S 1 FT #SUB 86 86 PRO C 171 155 VAL D Protein S 1 FT #SUB 86 86 PRO C 175 159 ASP D Protein A 11 FT #SUB 86 86 PRO C 176 160 PHE D Protein S 1 FT #SUB 87 87 THR C 97 81 VAL D Protein S 2 FT #SUB 89 89 PHE C 181 165 ALA D Protein S 2 FT #SUB 90 90 PHE C 97 81 VAL D Protein S 2 FT #SUB 134 134 MET C 249 233 HIS D Protein S 1 FT #SUB 164 164 MET C 249 233 HIS D Protein S 2 FT #SUB 165 165 SER C 249 233 HIS D Protein B 1 FT #SUB 166 166 ASP C 249 233 HIS D Protein B 2 FT #SUB 166 166 ASP C 252 236 LEU D Protein S 3 FT #SUB 166 166 ASP C 272 256 ARG D Protein S 9 FT #SUB 167 167 GLY C 249 233 HIS D Protein B 3 FT #SUB 167 167 GLY C 250 234 VAL D Protein B 6 FT #SUB 167 167 GLY C 252 236 LEU D Protein B 2 FT #SUB 167 167 GLY C 254 238 HIS D Protein B 4 FT #SUB 168 168 GLU C 250 234 VAL D Protein B 1 FT #SUB 169 169 PHE C 223 207 PRO D Protein S 7 FT #SUB 169 169 PHE C 226 210 LEU D Protein S 5 FT #SUB 169 169 PHE C 250 234 VAL D Protein S 5 FT #SUB 171 171 ARG C 220 204 PRO D Protein S 2 FT #SUB 188 188 ARG C 221 205 ILE D Protein S 2 FT #SUB 189 189 LEU C 221 205 ILE D Protein S 1 FT #SUB 191 191 ALA C 225 209 HIS D Protein S 1 FT #SUB 191 191 ALA C 250 234 VAL D Protein A 2 FT #SUB 194 194 GLU C 225 209 HIS D Protein S 3 FT #SUB 253 253 PRO C 224 208 PRO D Protein S 1 FT #SUB 254 254 LEU C 224 208 PRO D Protein S 2 FT #SUB 254 254 LEU C 228 212 GLN D Protein S 4 FT #SUB 339 339 GLU C 243 227 LEU D Protein B 1 FT #SUB 341 341 TYR C 276 260 LYS D Protein S 2 FT #SUB 342 342 LEU C 243 227 LEU D Protein B 1 FT #SUB 342 342 LEU C 244 228 LEU D Protein S 1 FT #SUB 342 342 LEU C 246 230 GLU D Protein S 1 FT #SUB 343 343 ALA C 235 219 THR D Protein S 1 FT #SUB 343 343 ALA C 243 227 LEU D Protein A 4 FT #SUB 343 343 ALA C 244 228 LEU D Protein A 5 FT #SUB 343 343 ALA C 245 229 PRO D Protein S 1 FT #SUB 344 344 SER C 235 219 THR D Protein B 4 FT #SUB 344 344 SER C 236 220 GLY D Protein A 3 FT #SUB 344 344 SER C 239 223 CYS D Protein A 4 FT #SUB 345 345 SER C 236 220 GLY D Protein B 4 FT #SUB 363 363 LEU C 237 221 ILE D Protein B 1 FT #SUB 364 364 LYS C 238 222 SER D Protein B 2 FT #SUB 365 365 PRO C 237 221 ILE D Protein A 6 FT #SUB 366 366 HIS C 237 221 ILE D Protein A 4 FT #SUB 366 366 HIS C 238 222 SER D Protein A 4 FT #SUB 366 366 HIS C 239 223 CYS D Protein S 6 FT #SUB 366 366 HIS C 240 224 ASP D Protein S 3 FT #SUB 368 368 GLU C 241 225 PRO D Protein B 2 FT #SUB 369 369 ARG C 235 219 THR D Protein S 6 FT #SUB 369 369 ARG C 236 220 GLY D Protein S 3 FT #SUB 369 369 ARG C 237 221 ILE D Protein S 4 FT #SUB 369 369 ARG C 239 223 CYS D Protein S 5 FT #SUB 369 369 ARG C 240 224 ASP D Protein S 2 FT #SUB 369 369 ARG C 241 225 PRO D Protein S 2 FT #SUB 401 401 LYS C 232 216 ASN D Protein A 4 FT #SUB 401 401 LYS C 258 242 LEU D Protein B 2 FT #SUB 402 402 TRP C 231 215 LEU D Protein S 7 FT #SUB 402 402 TRP C 232 216 ASN D Protein A 7 FT #SUB 402 402 TRP C 256 240 TYR D Protein S 2 FT #SUB 402 402 TRP C 257 241 ALA D Protein A 7 FT #SUB 402 402 TRP C 258 242 LEU D Protein S 13 FT #SUB 402 402 TRP C 266 250 VAL D Protein S 2 FT #SUB 402 402 TRP C 267 251 LEU D Protein S 1 FT #SUB 402 402 TRP C 268 252 SER D Protein S 3 FT #SUB 402 402 TRP C 281 265 LEU D Protein S 2 FT #SUB 403 403 HIS C 256 240 TYR D Protein B 5 FT #SUB 403 403 HIS C 257 241 ALA D Protein A 9 FT #SUB 403 403 HIS C 258 242 LEU D Protein S 1 FT #SUB 403 403 HIS C 259 243 SER D Protein S 2 FT #SUB 404 404 LEU C 222 206 LEU D Protein S 1 FT #SUB 404 404 LEU C 226 210 LEU D Protein S 1 FT #SUB 404 404 LEU C 254 238 HIS D Protein S 1 FT #SUB 404 404 LEU C 255 239 LEU D Protein A 2 FT #SUB 404 404 LEU C 256 240 TYR D Protein A 7 FT #SUB 405 405 GLY C 255 239 LEU D Protein B 1 FT #SUB 420 420 TYR C 207 191 PRO D Protein S 5 FT #SUB 420 420 TYR C 208 192 TYR D Protein S 1 FT #SUB 427 427 ASP C 205 189 GLN D Protein S 4 FT #SUB 428 428 PHE C 205 189 GLN D Protein B 1 FT #SUB 429 429 GLU C 203 187 TYR D Protein B 3 FT #SUB 429 429 GLU C 204 188 HIS D Protein A 3 FT #SUB 430 430 TRP C 203 187 TYR D Protein B 3 FT #SUB 430 430 TRP C 204 188 HIS D Protein A 15 FT #SUB 430 430 TRP C 205 189 GLN D Protein S 8 FT #SUB 430 430 TRP C 206 190 GLU D Protein S 4 FT #SUB 430 430 TRP C 207 191 PRO D Protein S 3 FT #SUB 431 431 LYS C 201 185 GLY D Protein S 3 FT #SUB 431 431 LYS C 202 186 PRO D Protein S 4 FT #SUB 431 431 LYS C 203 187 TYR D Protein A 17 FT #SUB 436 436 TYR C 218 202 ALA D Protein S 2 FT #SUB 436 436 TYR C 219 203 PRO D Protein S 7 FT #SUB 439 439 ARG C 203 187 TYR D Protein A 2 FT #SUB 441 441 ARG C 203 187 TYR D Protein S 6 FT #SUB 452 452 LYS C 203 187 TYR D Protein S 5 FT #SUB 456 456 GLN C 220 204 PRO D Protein S 2 FT #SUB 457 457 LEU C 219 203 PRO D Protein B 1 FT #SUB 457 457 LEU C 220 204 PRO D Protein B 1 FT #SUB 458 458 TYR C 220 204 PRO D Protein A 5 FT #SUB 458 458 TYR C 221 205 ILE D Protein S 2 FT #SUB 458 458 TYR C 222 206 LEU D Protein S 8 FT #SUB 458 458 TYR C 223 207 PRO D Protein S 1 FT #SUB 459 459 LEU C 219 203 PRO D Protein S 1 FT #SUB 459 459 LEU C 220 204 PRO D Protein A 4 FT #SUB 459 459 LEU C 221 205 ILE D Protein B 3 FT #SUB 459 459 LEU C 222 206 LEU D Protein B 3 FT #SUB 465 465 TYR C 219 203 PRO D Protein S 1 FT #SUB 468 468 ASP C 254 238 HIS D Protein S 8 FT #SUB 469 469 PHE C 253 237 ASN D Protein B 1 FT #SUB 469 469 PHE C 254 238 HIS D Protein B 2 FT #SUB 469 469 PHE C 255 239 LEU D Protein A 6 FT #SUB 470 470 LYS C 253 237 ASN D Protein B 2 FT #SUB 471 471 SER C 253 237 ASN D Protein A 4 FT #SUB 471 471 SER C 271 255 HIS D Protein S 2 FT #SUB 536 536 THR C 271 255 HIS D Protein S 5 FT #SUB 536 536 THR C 280 264 THR D Protein S 1 FT #SUB 539 539 PHE C 253 237 ASN D Protein S 2 FT #SUB 540 540 PHE C 255 239 LEU D Protein S 1 FT #SUB 540 540 PHE C 267 251 LEU D Protein B 1 FT #SUB 540 540 PHE C 268 252 SER D Protein S 4 FT #SUB 540 540 PHE C 269 253 ALA D Protein S 3 FT #SUB 540 540 PHE C 280 264 THR D Protein S 1 FT #SUB 540 540 PHE C 282 266 LEU D Protein S 2 FT #SUB 541 541 GLU C 284 268 LYS D Protein S 2 FT #SUB 543 543 CYS C 255 239 LEU D Protein S 3 FT #SUB 544 544 ALA C 265 249 MET D Protein A 3 FT #SUB 544 544 ALA C 267 251 LEU D Protein A 2 FT #SUB 544 544 ALA C 284 268 LYS D Protein S 1 FT #SUB 547 547 ILE C 255 239 LEU D Protein S 1 FT #SUB 548 548 THR C 265 249 MET D Protein S 1 FT #SUB 548 548 THR C 286 270 ILE D Protein S 1 FT #SUB 330 330 ASN C 36 36 HIS F Protein S 1 FT #SUB 330 330 ASN C 179 179 PHE F Protein S 3 FT #SUB 333 333 ILE C 178 178 LEU F Protein S 1 FT #SUB 333 333 ILE C 179 179 PHE F Protein S 1 FT #SUB 333 333 ILE C 182 182 GLU F Protein S 4 FT #SUB 334 334 MET C 40 40 ASP F Protein S 1 FT #SUB 340 340 PHE C 171 171 ARG F Protein A 20 FT #SUB 340 340 PHE C 174 174 LYS F Protein S 6 FT #SUB 340 340 PHE C 175 175 PHE F Protein S 1 FT #SUB 341 341 TYR C 40 40 ASP F Protein S 4 FT #SUB 341 341 TYR C 42 42 ILE F Protein S 2 FT #SUB 341 341 TYR C 43 43 PRO F Protein A 4 FT #SUB 341 341 TYR C 44 44 THR F Protein A 6 FT #SUB 341 341 TYR C 45 45 SER F Protein B 1 FT #SUB 341 341 TYR C 175 175 PHE F Protein S 2 FT #SUB 342 342 LEU C 44 44 THR F Protein S 2 FT #SUB 342 342 LEU C 45 45 SER F Protein S 2 FT #SUB 366 366 HIS C 296 296 GLU F Protein S 5 FT #SUB 367 367 PRO C 244 244 PHE F Protein B 2 FT #SUB 367 367 PRO C 295 295 ALA F Protein S 1 FT #SUB 367 367 PRO C 296 296 GLU F Protein S 1 FT #SUB 368 368 GLU C 70 70 ARG F Protein S 6 FT #SUB 368 368 GLU C 170 170 LYS F Protein S 5 FT #SUB 368 368 GLU C 244 244 PHE F Protein B 5 FT #SUB 370 370 MET C 64 64 LEU F Protein S 2 FT #SUB 370 370 MET C 65 65 VAL F Protein S 4 FT #SUB 370 370 MET C 68 68 GLY F Protein S 4 FT #SUB 370 370 MET C 69 69 VAL F Protein S 2 FT #SUB 370 370 MET C 244 244 PHE F Protein S 1 FT #SUB 370 370 MET C 247 247 ILE F Protein S 1 FT #SUB 371 371 PRO C 65 65 VAL F Protein B 1 FT #SUB 371 371 PRO C 248 248 ASN F Protein S 1 FT #SUB 372 372 PRO C 251 251 ALA F Protein B 1 FT #SUB 373 373 LEU C 65 65 VAL F Protein S 1 FT #SUB 373 373 LEU C 66 66 THR F Protein S 1 FT #SUB 373 373 LEU C 250 250 ALA F Protein S 1 FT #SUB 373 373 LEU C 251 251 ALA F Protein A 5 FT #SUB 374 374 ILE C 251 251 ALA F Protein A 5 FT #SUB 444 444 ASN C 80 80 GLN F Protein S 2 FT #SUB 446 446 VAL C 78 78 LYS F Protein S 1 FT #SUB 446 446 VAL C 80 80 GLN F Protein S 3 FT #SUB 531 531 ARG C 158 158 PRO F Protein B 2 FT #SUB 531 531 ARG C 159 159 GLU F Protein B 1 FT #SUB 533 533 GLY C 80 80 GLN F Protein B 2 FT #SUB 533 533 GLY C 160 160 SER F Protein B 1 FT #SUB 533 533 GLY C 161 161 GLY F Protein B 3 FT #SUB 534 534 SER C 75 75 TRP F Protein B 1 FT #SUB 534 534 SER C 160 160 SER F Protein B 2 FT #SUB 534 534 SER C 161 161 GLY F Protein A 6 FT #SUB 534 534 SER C 162 162 ASN F Protein A 7 FT #SUB 535 535 HIS C 160 160 SER F Protein A 3 FT #SUB 535 535 HIS C 162 162 ASN F Protein B 3 FT #SUB 536 536 THR C 162 162 ASN F Protein A 10 FT #SUB 537 537 MET C 50 50 VAL F Protein S 1 FT #SUB 537 537 MET C 75 75 TRP F Protein S 10 FT #SUB 537 537 MET C 82 82 PHE F Protein S 1 FT #SUB 538 538 ASP C 80 80 GLN F Protein S 1 FT #SUB 541 541 GLU C 75 75 TRP F Protein S 3 FT #SUB 541 541 GLU C 77 77 SER F Protein S 1 FT #SUB 541 541 GLU C 80 80 GLN F Protein S 5 FT #HET 11 11 VAL C 7 602 992 C S 1 FT #HET 18 18 LEU C 7 602 992 C A 3 FT #HET 22 22 LEU C 6 601 STU C A 6 FT #HET 23 23 GLY C 6 601 STU C B 4 FT #HET 24 24 VAL C 6 601 STU C B 3 FT #HET 25 25 GLY C 6 601 STU C B 2 FT #HET 28 28 GLY C 7 602 992 C B 1 FT #HET 29 29 LYS C 7 602 992 C A 2 FT #HET 30 30 VAL C 6 601 STU C S 4 FT #HET 31 31 LYS C 7 602 992 C S 5 FT #HET 43 43 ALA C 6 601 STU C S 3 FT #HET 45 45 LYS C 6 601 STU C S 1 FT #HET 46 46 ILE C 7 602 992 C A 4 FT #HET 48 48 ASN C 7 602 992 C S 1 FT #HET 51 51 LYS C 7 602 992 C S 6 FT #HET 77 77 ILE C 6 601 STU C S 2 FT #HET 88 88 ASP C 7 602 992 C S 6 FT #HET 90 90 PHE C 7 602 992 C S 1 FT #HET 93 93 MET C 6 601 STU C S 1 FT #HET 94 94 GLU C 6 601 STU C B 5 FT #HET 95 95 TYR C 6 601 STU C A 5 FT #HET 96 96 VAL C 6 601 STU C A 6 FT #HET 99 99 GLY C 6 601 STU C B 1 FT #HET 100 100 GLU C 6 601 STU C S 7 FT #HET 143 143 GLU C 6 601 STU C A 8 FT #HET 144 144 ASN C 6 601 STU C A 3 FT #HET 146 146 LEU C 6 601 STU C S 7 FT #HET 156 156 ALA C 6 601 STU C S 1 FT #HET 157 157 ASP C 6 601 STU C S 6 FT #HET 367 367 PRO C 9 402 AMP F A 3 FT #HET 368 368 GLU C 9 402 AMP F S 1 FT DISORDER 1 8 FT DISORDER 298 299 FT DISORDER 302 318 FT DISORDER 346 362 FT DISORDER 375 395 FT DISORDER 475 530 FT DISORDER 551 552 CC Miss-SC 2 CC SEQUENCE 429 AA (ATOM); CC GRVKIGHYVL GDTLGVGTFG KVKIGEHQLT GHKVAVKILN RQKIRSLDVV GKIKREIQNL CC KLFRHPHIIK LYQVISTPTD FFMVMEYVSG GELFDYICKH GRVEEMEARR LFQQILSAVD CC YCHRHMVVHR DLKPENVLLD AHMNAKIADF GLSNMMSDGE FLRTSCGSPN YAAPEVISGR CC LYAGPEVDIW SCGVILYALL CGTLPFDDEH VPTLFKKIRG GVFYIPEYLN RSVATLLMHM CC LQVDPLKRAT IKDIREHEWF KQDLPSYLFP EDPSYDANVI DDEAVKEVCF EQLAVAYHLI CC IDNRRIMNQA SEFYLASSLK PHPERMPPLI AVKKAKWHLG IRSQSKPYDI MAEVYRAMKQ CC LDFEWKVVNA YHLRVRRKNP VTGNYVKMSL QLYLVDNRSY LLDFKSIDDR LGSHTMDFFE CC MCASLITTL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ CC ATOM --------GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQ CC ****************************************** CC SEQRES KIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE CC ATOM KIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGE CC ************************************************** CC SEQRES LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH CC ATOM LFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAH CC ************************************************** CC SEQRES MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC CC ATOM MNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC CC ************************************************** CC SEQRES GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ CC ATOM GVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQ CC ************************************************** CC SEQRES VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF CC ATOM VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVC--F CC *********************************************** * CC SEQRES ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGS CC ATOM E-----------------QLAVAYHLIIDNRRIMNQASEFYLASS----- CC * *************************** CC SEQRES FMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKA CC ATOM ------------LKPHPERMPPLI---------------------AVKKA CC ************ ***** CC SEQRES KWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNY CC ATOM KWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNY CC ************************************************** CC SEQRES VKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRS CC ATOM VKMSLQLYLVDNRSYLLDFKSIDD-------------------------- CC ************************ CC SEQRES SFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTL CC ATOM ------------------------------RLGSHTMDFFEMCASLITTL CC ******************** CC SEQRES AR CC ATOM -- CC SQ SEQUENCE 552 AA; MW; CN; MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEMEARRLF QQILSAVDYC HRHMVVHRDL KPENVLLDAH MNAKIADFGL SNMMSDGEFL RTSCGSPNYA APEVISGRLY AGPEVDIWSC GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS VATLLMHMLQ VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPSGS FMDDSAMHIP PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA KWHLGIRSQS KPYDIMAEVY RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR SGSSTPQRSC SAAGLHRPRS SFDSTTAESH SLSGSLTGSL TGSTLSSVSP RLGSHTMDFF EMCASLITTL AR // ID 5ISOD STANDARD; PRT; 286 AA. DT CONVERTED FROM PDB (SEQRES) 5ISO DE 5'-AMP-activated protein kinase subunit beta-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.630 CC R-Factor 0.180 FT #SUB 101 85 THR D 421 421 ARG A Protein B 1 FT #SUB 101 85 THR D 425 425 GLN A Protein S 6 FT #SUB 102 86 GLY D 421 421 ARG A Protein B 2 FT #SUB 103 87 GLY D 421 421 ARG A Protein B 3 FT #SUB 126 110 ASN D 421 421 ARG A Protein S 2 FT #SUB 126 110 ASN D 425 425 GLN A Protein S 1 FT #SUB 151 135 HIS D 286 270 ILE B Protein S 3 FT #SUB 95 79 PRO D 85 85 THR C Protein A 4 FT #SUB 95 79 PRO D 86 86 PRO C Protein B 1 FT #SUB 97 81 VAL D 85 85 THR C Protein S 1 FT #SUB 97 81 VAL D 87 87 THR C Protein A 2 FT #SUB 97 81 VAL D 90 90 PHE C Protein S 2 FT #SUB 99 83 ARG D 48 48 ASN C Protein S 1 FT #SUB 122 106 THR D 9 9 GLY C Protein S 1 FT #SUB 122 106 THR D 11 11 VAL C Protein S 1 FT #SUB 124 108 SEP D 21 21 THR C Protein S 1 FT #SUB 124 108 SEP D 29 29 LYS C Protein S 3 FT #SUB 124 108 SEP D 31 31 LYS C Protein S 5 FT #SUB 127 111 ASN D 29 29 LYS C Protein S 1 FT #SUB 129 113 VAL D 11 11 VAL C Protein S 2 FT #SUB 131 115 ILE D 11 11 VAL C Protein S 2 FT #SUB 131 115 ILE D 12 12 LYS C Protein S 3 FT #SUB 171 155 VAL D 86 86 PRO C Protein S 1 FT #SUB 175 159 ASP D 49 49 ARG C Protein A 6 FT #SUB 175 159 ASP D 84 84 SER C Protein B 6 FT #SUB 175 159 ASP D 85 85 THR C Protein B 4 FT #SUB 175 159 ASP D 86 86 PRO C Protein S 11 FT #SUB 176 160 PHE D 84 84 SER C Protein A 3 FT #SUB 176 160 PHE D 86 86 PRO C Protein S 1 FT #SUB 178 162 VAL D 84 84 SER C Protein B 2 FT #SUB 179 163 PHE D 69 69 LYS C Protein S 1 FT #SUB 181 165 ALA D 49 49 ARG C Protein A 4 FT #SUB 181 165 ALA D 84 84 SER C Protein S 1 FT #SUB 181 165 ALA D 89 89 PHE C Protein S 2 FT #SUB 182 166 LEU D 58 58 VAL C Protein A 3 FT #SUB 185 169 ASP D 49 49 ARG C Protein S 4 FT #SUB 185 169 ASP D 53 53 ARG C Protein S 1 FT #SUB 186 170 SER D 58 58 VAL C Protein B 2 FT #SUB 188 172 LYS D 53 53 ARG C Protein S 1 FT #SUB 188 172 LYS D 56 56 ASP C Protein A 4 FT #SUB 201 185 GLY D 431 431 LYS C Protein B 3 FT #SUB 202 186 PRO D 431 431 LYS C Protein B 4 FT #SUB 203 187 TYR D 429 429 GLU C Protein S 3 FT #SUB 203 187 TYR D 430 430 TRP C Protein S 3 FT #SUB 203 187 TYR D 431 431 LYS C Protein A 17 FT #SUB 203 187 TYR D 439 439 ARG C Protein S 2 FT #SUB 203 187 TYR D 441 441 ARG C Protein S 6 FT #SUB 203 187 TYR D 452 452 LYS C Protein S 5 FT #SUB 204 188 HIS D 429 429 GLU C Protein B 3 FT #SUB 204 188 HIS D 430 430 TRP C Protein A 15 FT #SUB 205 189 GLN D 427 427 ASP C Protein S 4 FT #SUB 205 189 GLN D 428 428 PHE C Protein S 1 FT #SUB 205 189 GLN D 430 430 TRP C Protein B 8 FT #SUB 206 190 GLU D 430 430 TRP C Protein B 4 FT #SUB 207 191 PRO D 420 420 TYR C Protein S 5 FT #SUB 207 191 PRO D 430 430 TRP C Protein A 3 FT #SUB 208 192 TYR D 420 420 TYR C Protein B 1 FT #SUB 218 202 ALA D 436 436 TYR C Protein B 2 FT #SUB 219 203 PRO D 436 436 TYR C Protein A 7 FT #SUB 219 203 PRO D 457 457 LEU C Protein S 1 FT #SUB 219 203 PRO D 459 459 LEU C Protein B 1 FT #SUB 219 203 PRO D 465 465 TYR C Protein S 1 FT #SUB 220 204 PRO D 171 171 ARG C Protein S 2 FT #SUB 220 204 PRO D 456 456 GLN C Protein S 2 FT #SUB 220 204 PRO D 457 457 LEU C Protein S 1 FT #SUB 220 204 PRO D 458 458 TYR C Protein B 5 FT #SUB 220 204 PRO D 459 459 LEU C Protein B 4 FT #SUB 221 205 ILE D 188 188 ARG C Protein S 2 FT #SUB 221 205 ILE D 189 189 LEU C Protein B 1 FT #SUB 221 205 ILE D 458 458 TYR C Protein B 2 FT #SUB 221 205 ILE D 459 459 LEU C Protein A 3 FT #SUB 222 206 LEU D 404 404 LEU C Protein S 1 FT #SUB 222 206 LEU D 458 458 TYR C Protein A 8 FT #SUB 222 206 LEU D 459 459 LEU C Protein A 3 FT #SUB 223 207 PRO D 169 169 PHE C Protein S 7 FT #SUB 223 207 PRO D 458 458 TYR C Protein S 1 FT #SUB 224 208 PRO D 253 253 PRO C Protein S 1 FT #SUB 224 208 PRO D 254 254 LEU C Protein A 2 FT #SUB 225 209 HIS D 191 191 ALA C Protein S 1 FT #SUB 225 209 HIS D 194 194 GLU C Protein S 3 FT #SUB 226 210 LEU D 169 169 PHE C Protein S 5 FT #SUB 226 210 LEU D 404 404 LEU C Protein S 1 FT #SUB 228 212 GLN D 254 254 LEU C Protein S 4 FT #SUB 231 215 LEU D 402 402 TRP C Protein S 7 FT #SUB 232 216 ASN D 401 401 LYS C Protein S 4 FT #SUB 232 216 ASN D 402 402 TRP C Protein S 7 FT #SUB 235 219 THR D 343 343 ALA C Protein S 1 FT #SUB 235 219 THR D 344 344 SER C Protein A 4 FT #SUB 235 219 THR D 369 369 ARG C Protein A 6 FT #SUB 236 220 GLY D 344 344 SER C Protein B 3 FT #SUB 236 220 GLY D 345 345 SER C Protein B 4 FT #SUB 236 220 GLY D 369 369 ARG C Protein B 3 FT #SUB 237 221 ILE D 363 363 LEU C Protein S 1 FT #SUB 237 221 ILE D 365 365 PRO C Protein A 6 FT #SUB 237 221 ILE D 366 366 HIS C Protein B 4 FT #SUB 237 221 ILE D 369 369 ARG C Protein B 4 FT #SUB 238 222 SER D 364 364 LYS C Protein A 2 FT #SUB 238 222 SER D 366 366 HIS C Protein B 4 FT #SUB 239 223 CYS D 344 344 SER C Protein S 4 FT #SUB 239 223 CYS D 366 366 HIS C Protein B 6 FT #SUB 239 223 CYS D 369 369 ARG C Protein A 5 FT #SUB 240 224 ASP D 366 366 HIS C Protein B 3 FT #SUB 240 224 ASP D 369 369 ARG C Protein B 2 FT #SUB 241 225 PRO D 368 368 GLU C Protein S 2 FT #SUB 241 225 PRO D 369 369 ARG C Protein B 2 FT #SUB 243 227 LEU D 339 339 GLU C Protein S 1 FT #SUB 243 227 LEU D 342 342 LEU C Protein S 1 FT #SUB 243 227 LEU D 343 343 ALA C Protein A 4 FT #SUB 244 228 LEU D 342 342 LEU C Protein B 1 FT #SUB 244 228 LEU D 343 343 ALA C Protein B 5 FT #SUB 245 229 PRO D 343 343 ALA C Protein B 1 FT #SUB 246 230 GLU D 342 342 LEU C Protein B 1 FT #SUB 249 233 HIS D 134 134 MET C Protein S 1 FT #SUB 249 233 HIS D 164 164 MET C Protein S 2 FT #SUB 249 233 HIS D 165 165 SER C Protein S 1 FT #SUB 249 233 HIS D 166 166 ASP C Protein B 2 FT #SUB 249 233 HIS D 167 167 GLY C Protein B 3 FT #SUB 250 234 VAL D 167 167 GLY C Protein B 6 FT #SUB 250 234 VAL D 168 168 GLU C Protein S 1 FT #SUB 250 234 VAL D 169 169 PHE C Protein S 5 FT #SUB 250 234 VAL D 191 191 ALA C Protein S 2 FT #SUB 252 236 LEU D 166 166 ASP C Protein S 3 FT #SUB 252 236 LEU D 167 167 GLY C Protein B 2 FT #SUB 253 237 ASN D 469 469 PHE C Protein B 1 FT #SUB 253 237 ASN D 470 470 LYS C Protein B 2 FT #SUB 253 237 ASN D 471 471 SER C Protein A 4 FT #SUB 253 237 ASN D 539 539 PHE C Protein B 2 FT #SUB 254 238 HIS D 167 167 GLY C Protein S 4 FT #SUB 254 238 HIS D 404 404 LEU C Protein S 1 FT #SUB 254 238 HIS D 468 468 ASP C Protein S 8 FT #SUB 254 238 HIS D 469 469 PHE C Protein B 2 FT #SUB 255 239 LEU D 404 404 LEU C Protein B 2 FT #SUB 255 239 LEU D 405 405 GLY C Protein B 1 FT #SUB 255 239 LEU D 469 469 PHE C Protein A 6 FT #SUB 255 239 LEU D 540 540 PHE C Protein S 1 FT #SUB 255 239 LEU D 543 543 CYS C Protein S 3 FT #SUB 255 239 LEU D 547 547 ILE C Protein S 1 FT #SUB 256 240 TYR D 402 402 TRP C Protein B 2 FT #SUB 256 240 TYR D 403 403 HIS C Protein A 5 FT #SUB 256 240 TYR D 404 404 LEU C Protein S 7 FT #SUB 257 241 ALA D 402 402 TRP C Protein B 7 FT #SUB 257 241 ALA D 403 403 HIS C Protein B 9 FT #SUB 258 242 LEU D 401 401 LYS C Protein S 2 FT #SUB 258 242 LEU D 402 402 TRP C Protein A 13 FT #SUB 258 242 LEU D 403 403 HIS C Protein B 1 FT #SUB 259 243 SER D 403 403 HIS C Protein A 2 FT #SUB 265 249 MET D 544 544 ALA C Protein S 3 FT #SUB 265 249 MET D 548 548 THR C Protein S 1 FT #SUB 266 250 VAL D 402 402 TRP C Protein A 2 FT #SUB 267 251 LEU D 402 402 TRP C Protein B 1 FT #SUB 267 251 LEU D 540 540 PHE C Protein S 1 FT #SUB 267 251 LEU D 544 544 ALA C Protein S 2 FT #SUB 268 252 SER D 402 402 TRP C Protein A 3 FT #SUB 268 252 SER D 540 540 PHE C Protein B 4 FT #SUB 269 253 ALA D 540 540 PHE C Protein A 3 FT #SUB 271 255 HIS D 471 471 SER C Protein S 2 FT #SUB 271 255 HIS D 536 536 THR C Protein S 5 FT #SUB 272 256 ARG D 166 166 ASP C Protein S 9 FT #SUB 276 260 LYS D 341 341 TYR C Protein S 2 FT #SUB 280 264 THR D 536 536 THR C Protein S 1 FT #SUB 280 264 THR D 540 540 PHE C Protein B 1 FT #SUB 281 265 LEU D 402 402 TRP C Protein S 2 FT #SUB 282 266 LEU D 540 540 PHE C Protein S 2 FT #SUB 284 268 LYS D 541 541 GLU C Protein S 2 FT #SUB 284 268 LYS D 544 544 ALA C Protein S 1 FT #SUB 286 270 ILE D 548 548 THR C Protein S 1 FT #SUB 231 215 LEU D 47 47 LYS F Protein S 1 FT #SUB 241 225 PRO D 68 68 GLY F Protein S 2 FT #SUB 242 226 ALA D 46 46 SER F Protein B 3 FT #SUB 242 226 ALA D 47 47 LYS F Protein B 4 FT #SUB 243 227 LEU D 43 43 PRO F Protein S 2 FT #SUB 243 227 LEU D 45 45 SER F Protein A 3 FT #SUB 244 228 LEU D 45 45 SER F Protein A 9 FT #SUB 244 228 LEU D 46 46 SER F Protein S 2 FT #SUB 244 228 LEU D 47 47 LYS F Protein S 2 FT #SUB 245 229 PRO D 45 45 SER F Protein B 4 FT #SUB 247 231 PRO D 45 45 SER F Protein S 1 FT #SUB 263 247 GLY D 59 59 LYS F Protein B 1 FT #SUB 264 248 VAL D 55 55 LEU F Protein S 1 FT #SUB 264 248 VAL D 59 59 LYS F Protein S 2 FT #SUB 273 257 TYR D 39 39 TYR F Protein A 5 FT #SUB 273 257 TYR D 134 134 PRO F Protein S 3 FT #SUB 273 257 TYR D 157 157 ASP F Protein S 2 FT #SUB 273 257 TYR D 164 164 LEU F Protein S 3 FT #SUB 274 258 LYS D 39 39 TYR F Protein S 3 FT #SUB 274 258 LYS D 135 135 ASN F Protein S 1 FT #SUB 275 259 LYS D 39 39 TYR F Protein A 3 FT #SUB 276 260 LYS D 39 39 TYR F Protein S 9 FT #SUB 276 260 LYS D 42 42 ILE F Protein S 6 FT #SUB 276 260 LYS D 43 43 PRO F Protein S 3 FT #SUB 276 260 LYS D 44 44 THR F Protein A 3 FT #SUB 277 261 TYR D 44 44 THR F Protein A 9 FT #SUB 277 261 TYR D 45 45 SER F Protein B 2 FT #SUB 277 261 TYR D 46 46 SER F Protein B 2 FT #SUB 278 262 VAL D 46 46 SER F Protein B 2 FT #SUB 278 262 VAL D 164 164 LEU F Protein S 2 FT #SUB 279 263 THR D 46 46 SER F Protein A 4 FT #SUB 279 263 THR D 47 47 LYS F Protein B 2 FT #SUB 279 263 THR D 48 48 LEU F Protein B 3 FT #SUB 280 264 THR D 48 48 LEU F Protein A 3 FT #SUB 280 264 THR D 50 50 VAL F Protein S 1 FT #SUB 281 265 LEU D 47 47 LYS F Protein S 1 FT #SUB 281 265 LEU D 48 48 LEU F Protein A 6 FT #SUB 281 265 LEU D 49 49 VAL F Protein B 2 FT #SUB 281 265 LEU D 50 50 VAL F Protein B 7 FT #SUB 281 265 LEU D 67 67 ASN F Protein S 2 FT #SUB 282 266 LEU D 50 50 VAL F Protein A 3 FT #SUB 282 266 LEU D 52 52 ASP F Protein S 1 FT #SUB 283 267 TYR D 49 49 VAL F Protein S 2 FT #SUB 283 267 TYR D 50 50 VAL F Protein B 1 FT #SUB 283 267 TYR D 51 51 PHE F Protein S 4 FT #SUB 283 267 TYR D 52 52 ASP F Protein B 3 FT #SUB 283 267 TYR D 63 63 ALA F Protein S 3 FT #SUB 283 267 TYR D 67 67 ASN F Protein S 4 FT #SUB 284 268 LYS D 52 52 ASP F Protein S 1 FT #SUB 285 269 PRO D 52 52 ASP F Protein S 1 FT #SUB 285 269 PRO D 54 54 SER F Protein S 4 FT #SUB 285 269 PRO D 55 55 LEU F Protein S 2 FT #HET 97 81 VAL D 7 602 992 C S 1 FT #HET 99 83 ARG D 7 602 992 C S 21 FT #HET 122 106 THR D 7 602 992 C A 4 FT #HET 123 107 ARG D 7 602 992 C B 2 FT #HET 124 108 SEP D 7 602 992 C A 4 FT #HET 127 111 ASN D 7 602 992 C S 4 FT #HET 129 113 VAL D 7 602 992 C S 7 FT #HET 131 115 ILE D 7 602 992 C S 1 FT DISORDER 1 93 FT DISORDER 160 160 FT DISORDER 189 199 FT DISORDER 210 217 CC Miss-BB 1 CC Miss-SC 1 CC SEQUENCE 173 AA (ATOM); CC RPTVFRWTGG GKEVYLSGSF NNWSKLPLTR XHNNFVAILD LPEGEHQYKF FVDGQWTHDP CC SEPIVTQLGT VNNIIQVKKT DFEVFDALMV DSQKPGPYHQ EPYVAPPILP PHLLQVILNK CC DTGISCDPAL LPEPNHVMLN HLYALSIKDG VMVLSATHRY KKKYVTTLLY KPI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MGLNDIFEAQKIEWHEMGNTSSERAALERHGGHKTPRRDSSGGTKDGDRP CC ATOM -------------------------------------------------- CC CC SEQRES KILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRW CC ATOM -------------------------------------------RPTVFRW CC ******* CC SEQRES TGGGKEVYLSGSFNNWSKLPLTRXHNNFVAILDLPEGEHQYKFFVDGQWT CC ATOM TGGGKEVYLSGSFNNWSKLPLTRXHNNFVAILDLPEGEHQYKFFVDGQWT CC ************************************************** CC SEQRES HDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPP CC ATOM HDPSEPIVT-QLGTVNNIIQVKKTDFEVFDALMVDSQK-----------P CC ********* **************************** * CC SEQRES GPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHV CC ATOM GPYHQEPYV--------APPILPPHLLQVILNKDTGISCDPALLPEPNHV CC ********* ********************************* CC SEQRES MLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI CC ATOM MLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI CC ************************************ SQ SEQUENCE 286 AA; MW; CN; MGLNDIFEAQ KIEWHEMGNT SSERAALERH GGHKTPRRDS SGGTKDGDRP KILMDSPEDA DLFHSEEIKA PEKEEFLAWQ HDLEVNDKAP AQARPTVFRW TGGGKEVYLS GSFNNWSKLP LTRXHNNFVA ILDLPEGEHQ YKFFVDGQWT HDPSEPIVTS QLGTVNNIIQ VKKTDFEVFD ALMVDSQKCS DVSELSSSPP GPYHQEPYVC KPEERFRAPP ILPPHLLQVI LNKDTGISCD PALLPEPNHV MLNHLYALSI KDGVMVLSAT HRYKKKYVTT LLYKPI // ID 5ISOF STANDARD; PRT; 331 AA. DT CONVERTED FROM PDB (SEQRES) 5ISO DE 5'-AMP-activated protein kinase subunit gamma-1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.630 CC R-Factor 0.180 FT #SUB 36 36 HIS F 330 330 ASN C Protein S 1 FT #SUB 40 40 ASP F 334 334 MET C Protein B 1 FT #SUB 40 40 ASP F 341 341 TYR C Protein B 4 FT #SUB 42 42 ILE F 341 341 TYR C Protein B 2 FT #SUB 43 43 PRO F 341 341 TYR C Protein A 4 FT #SUB 44 44 THR F 341 341 TYR C Protein A 6 FT #SUB 44 44 THR F 342 342 LEU C Protein S 2 FT #SUB 45 45 SER F 341 341 TYR C Protein B 1 FT #SUB 45 45 SER F 342 342 LEU C Protein A 2 FT #SUB 50 50 VAL F 537 537 MET C Protein S 1 FT #SUB 64 64 LEU F 370 370 MET C Protein B 2 FT #SUB 65 65 VAL F 370 370 MET C Protein B 4 FT #SUB 65 65 VAL F 371 371 PRO C Protein S 1 FT #SUB 65 65 VAL F 373 373 LEU C Protein S 1 FT #SUB 66 66 THR F 373 373 LEU C Protein S 1 FT #SUB 68 68 GLY F 370 370 MET C Protein B 4 FT #SUB 69 69 VAL F 370 370 MET C Protein B 2 FT #SUB 70 70 ARG F 368 368 GLU C Protein S 6 FT #SUB 75 75 TRP F 534 534 SER C Protein S 1 FT #SUB 75 75 TRP F 537 537 MET C Protein S 10 FT #SUB 75 75 TRP F 541 541 GLU C Protein S 3 FT #SUB 77 77 SER F 541 541 GLU C Protein S 1 FT #SUB 78 78 LYS F 446 446 VAL C Protein B 1 FT #SUB 80 80 GLN F 444 444 ASN C Protein S 2 FT #SUB 80 80 GLN F 446 446 VAL C Protein S 3 FT #SUB 80 80 GLN F 533 533 GLY C Protein B 2 FT #SUB 80 80 GLN F 538 538 ASP C Protein S 1 FT #SUB 80 80 GLN F 541 541 GLU C Protein S 5 FT #SUB 82 82 PHE F 537 537 MET C Protein S 1 FT #SUB 158 158 PRO F 531 531 ARG C Protein B 2 FT #SUB 159 159 GLU F 531 531 ARG C Protein B 1 FT #SUB 160 160 SER F 533 533 GLY C Protein B 1 FT #SUB 160 160 SER F 534 534 SER C Protein B 2 FT #SUB 160 160 SER F 535 535 HIS C Protein B 3 FT #SUB 161 161 GLY F 533 533 GLY C Protein B 3 FT #SUB 161 161 GLY F 534 534 SER C Protein B 6 FT #SUB 162 162 ASN F 534 534 SER C Protein A 7 FT #SUB 162 162 ASN F 535 535 HIS C Protein S 3 FT #SUB 162 162 ASN F 536 536 THR C Protein S 10 FT #SUB 170 170 LYS F 368 368 GLU C Protein S 5 FT #SUB 171 171 ARG F 340 340 PHE C Protein A 20 FT #SUB 174 174 LYS F 340 340 PHE C Protein S 6 FT #SUB 175 175 PHE F 340 340 PHE C Protein B 1 FT #SUB 175 175 PHE F 341 341 TYR C Protein S 2 FT #SUB 178 178 LEU F 333 333 ILE C Protein B 1 FT #SUB 179 179 PHE F 330 330 ASN C Protein S 3 FT #SUB 179 179 PHE F 333 333 ILE C Protein S 1 FT #SUB 182 182 GLU F 333 333 ILE C Protein S 4 FT #SUB 244 244 PHE F 367 367 PRO C Protein S 2 FT #SUB 244 244 PHE F 368 368 GLU C Protein S 5 FT #SUB 244 244 PHE F 370 370 MET C Protein S 1 FT #SUB 247 247 ILE F 370 370 MET C Protein S 1 FT #SUB 248 248 ASN F 371 371 PRO C Protein S 1 FT #SUB 250 250 ALA F 373 373 LEU C Protein B 1 FT #SUB 251 251 ALA F 372 372 PRO C Protein S 1 FT #SUB 251 251 ALA F 373 373 LEU C Protein B 5 FT #SUB 251 251 ALA F 374 374 ILE C Protein B 5 FT #SUB 295 295 ALA F 367 367 PRO C Protein B 1 FT #SUB 296 296 GLU F 366 366 HIS C Protein S 5 FT #SUB 296 296 GLU F 367 367 PRO C Protein B 1 FT #SUB 39 39 TYR F 273 257 TYR D Protein S 5 FT #SUB 39 39 TYR F 274 258 LYS D Protein S 3 FT #SUB 39 39 TYR F 275 259 LYS D Protein S 3 FT #SUB 39 39 TYR F 276 260 LYS D Protein A 9 FT #SUB 42 42 ILE F 276 260 LYS D Protein A 6 FT #SUB 43 43 PRO F 243 227 LEU D Protein S 2 FT #SUB 43 43 PRO F 276 260 LYS D Protein B 3 FT #SUB 44 44 THR F 276 260 LYS D Protein B 3 FT #SUB 44 44 THR F 277 261 TYR D Protein B 9 FT #SUB 45 45 SER F 243 227 LEU D Protein B 3 FT #SUB 45 45 SER F 244 228 LEU D Protein A 9 FT #SUB 45 45 SER F 245 229 PRO D Protein S 4 FT #SUB 45 45 SER F 247 231 PRO D Protein S 1 FT #SUB 45 45 SER F 277 261 TYR D Protein B 2 FT #SUB 46 46 SER F 242 226 ALA D Protein A 3 FT #SUB 46 46 SER F 244 228 LEU D Protein B 2 FT #SUB 46 46 SER F 277 261 TYR D Protein A 2 FT #SUB 46 46 SER F 278 262 VAL D Protein B 2 FT #SUB 46 46 SER F 279 263 THR D Protein B 4 FT #SUB 47 47 LYS F 231 215 LEU D Protein S 1 FT #SUB 47 47 LYS F 242 226 ALA D Protein A 4 FT #SUB 47 47 LYS F 244 228 LEU D Protein A 2 FT #SUB 47 47 LYS F 279 263 THR D Protein B 2 FT #SUB 47 47 LYS F 281 265 LEU D Protein S 1 FT #SUB 48 48 LEU F 279 263 THR D Protein B 3 FT #SUB 48 48 LEU F 280 264 THR D Protein B 3 FT #SUB 48 48 LEU F 281 265 LEU D Protein B 6 FT #SUB 49 49 VAL F 281 265 LEU D Protein B 2 FT #SUB 49 49 VAL F 283 267 TYR D Protein S 2 FT #SUB 50 50 VAL F 280 264 THR D Protein S 1 FT #SUB 50 50 VAL F 281 265 LEU D Protein A 7 FT #SUB 50 50 VAL F 282 266 LEU D Protein B 3 FT #SUB 50 50 VAL F 283 267 TYR D Protein B 1 FT #SUB 51 51 PHE F 283 267 TYR D Protein S 4 FT #SUB 52 52 ASP F 282 266 LEU D Protein B 1 FT #SUB 52 52 ASP F 283 267 TYR D Protein A 3 FT #SUB 52 52 ASP F 284 268 LYS D Protein S 1 FT #SUB 52 52 ASP F 285 269 PRO D Protein S 1 FT #SUB 54 54 SER F 285 269 PRO D Protein A 4 FT #SUB 55 55 LEU F 264 248 VAL D Protein S 1 FT #SUB 55 55 LEU F 285 269 PRO D Protein B 2 FT #SUB 59 59 LYS F 263 247 GLY D Protein S 1 FT #SUB 59 59 LYS F 264 248 VAL D Protein S 2 FT #SUB 63 63 ALA F 283 267 TYR D Protein S 3 FT #SUB 67 67 ASN F 281 265 LEU D Protein S 2 FT #SUB 67 67 ASN F 283 267 TYR D Protein S 4 FT #SUB 68 68 GLY F 241 225 PRO D Protein B 2 FT #SUB 134 134 PRO F 273 257 TYR D Protein S 3 FT #SUB 135 135 ASN F 274 258 LYS D Protein S 1 FT #SUB 157 157 ASP F 273 257 TYR D Protein S 2 FT #SUB 164 164 LEU F 273 257 TYR D Protein S 3 FT #SUB 164 164 LEU F 278 262 VAL D Protein B 2 FT #HET 70 70 ARG F 9 402 AMP F S 4 FT #HET 85 85 MET F 8 401 AMP F A 4 FT #HET 87 87 THR F 8 401 AMP F S 7 FT #HET 89 89 THR F 8 401 AMP F S 6 FT #HET 90 90 ASP F 8 401 AMP F S 7 FT #HET 128 128 PRO F 8 401 AMP F B 1 FT #HET 129 129 LEU F 8 401 AMP F A 2 FT #HET 130 130 VAL F 8 401 AMP F A 11 FT #HET 150 150 ILE F 8 401 AMP F A 5 FT #HET 151 151 HIS F 8 401 AMP F A 6 FT #HET 151 151 HIS F 10 403 AMP F S 6 FT #HET 152 152 ARG F 8 401 AMP F B 3 FT #HET 154 154 PRO F 8 401 AMP F S 1 FT #HET 170 170 LYS F 9 402 AMP F S 5 FT #HET 200 200 THR F 10 403 AMP F A 7 FT #HET 203 203 ASN F 10 403 AMP F B 1 FT #HET 204 204 ILE F 10 403 AMP F B 3 FT #HET 205 205 ALA F 10 403 AMP F A 8 FT #HET 225 225 VAL F 10 403 AMP F A 10 FT #HET 226 226 SER F 10 403 AMP F A 7 FT #HET 227 227 ALA F 10 403 AMP F B 1 FT #HET 229 229 PRO F 10 403 AMP F S 1 FT #HET 240 240 ILE F 9 402 AMP F A 7 FT #HET 242 242 SER F 9 402 AMP F S 7 FT #HET 244 244 PHE F 9 402 AMP F S 1 FT #HET 245 245 ASP F 9 402 AMP F S 10 FT #HET 269 269 ARG F 9 402 AMP F S 5 FT #HET 273 273 PHE F 9 402 AMP F S 1 FT #HET 275 275 GLY F 9 402 AMP F B 1 FT #HET 276 276 VAL F 9 402 AMP F A 5 FT #HET 277 277 LEU F 9 402 AMP F A 13 FT #HET 297 297 VAL F 9 402 AMP F A 13 FT #HET 298 298 HIS F 9 402 AMP F A 3 FT #HET 298 298 HIS F 10 403 AMP F S 7 FT #HET 299 299 ARG F 9 402 AMP F A 16 FT #HET 300 300 LEU F 9 402 AMP F B 1 FT #HET 312 312 ILE F 10 403 AMP F A 3 FT #HET 314 314 SER F 10 403 AMP F S 5 FT #HET 316 316 SER F 10 403 AMP F S 4 FT #HET 317 317 ASP F 10 403 AMP F S 12 FT DISORDER 1 26 FT DISORDER 326 331 CC Miss-SC 2 CC SEQUENCE 299 AA (ATOM); CC SVYTSFMKSH RCYDLIPTSS KLVVFDTSLQ VKKAFFALVT NGVRAAPLWD SKKQSFVGML CC TITDFINILH RYYKSALVQI YELEEHKIET WREVYLQDSF KPLVCISPNA SLFDAVSSLI CC RNKIHRLPVI DPESGNTLYI LTHKRILKFL KLFITEFPKP EFMSKSLEEL QIGTYANIAM CC VRTTTPVYVA LGIFVQHRVS ALPVVDEKGR VVDIYSKFDV INLAAEKTYN NLDVSVTKAL CC QHRSHYFEGV LKCYLHETLE TIINRLVEAE VHRLVVVDEN DVVKGIVSLS DILQALVLT CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVV CC ATOM --------------------------SVYTSFMKSHRCYDLIPTSSKLVV CC ************************ CC SEQRES FDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYK CC ATOM FDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYK CC ************************************************** CC SEQRES SALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKI CC ATOM SALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKI CC ************************************************** CC SEQRES HRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGT CC ATOM HRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGT CC ************************************************** CC SEQRES YANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLA CC ATOM YANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLA CC ************************************************** CC SEQRES AEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL CC ATOM AEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL CC ************************************************** CC SEQRES VVVDENDVVKGIVSLSDILQALVLTGGEKKP CC ATOM VVVDENDVVKGIVSLSDILQALVLT------ CC ************************* SQ SEQUENCE 331 AA; MW; CN; METVISSDSS PAVENEHPQE TPESNNSVYT SFMKSHRCYD LIPTSSKLVV FDTSLQVKKA FFALVTNGVR AAPLWDSKKQ SFVGMLTITD FINILHRYYK SALVQIYELE EHKIETWREV YLQDSFKPLV CISPNASLFD AVSSLIRNKI HRLPVIDPES GNTLYILTHK RILKFLKLFI TEFPKPEFMS KSLEELQIGT YANIAMVRTT TPVYVALGIF VQHRVSALPV VDEKGRVVDI YSKFDVINLA AEKTYNNLDV SVTKALQHRS HYFEGVLKCY LHETLETIIN RLVEAEVHRL VVVDENDVVK GIVSLSDILQ ALVLTGGEKK P //