Brand  (β version)

PDB ID: 5F8P

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Ligands
Code Name Style Show Link
AKG 2-oxoglutaric acid PoSSuM
FE2 Fe (II) ion PoSSuM
FIJ 4-chloranyl-6-[(2~{S})-6-chloranyl-2,4,4-trimethyl-7-oxidanyl-3~{H}-chromen-2-yl]benzene-1,3-diol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5F8P   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : A Novel Inhibitor of the Obesity-Related Protein FTO
Release Data : 2016-12-14
Compound :
mol_id molecule chains synonym
1 Alpha-ketoglutarate-dependent dioxygenase FTO A Fat mass and obesity-associated protein
ec: 1.14.11.-
fragment: UNP residues 32-502
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FTO, KIAA1752
Authors : Chai, J., Zhou, B., Liu, W., Han, Z.
Keywords : Fat mass and obesity associated(FTO) protein, small molecule, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Crystal structure of FTO-CHTB

Chai, J.,Zhou, B.,Liu, W.  et al.
To Be Published 

Reaction

Chain : A
UniProt : Q9C0B1 (FTO_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O- dimethyladenosine) in mRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)- methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO2 - PubMed:28002401, PubMed:30197295
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an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2 1.14.11.53 PubMed:25452335, PubMed:26457839, PubMed:30197295, PubMed:22002720
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N(6)-methyladenosine in U6 snRNA + 2-oxoglutarate + O2 = adenosine in U6 snRNA + formaldehyde + succinate + CO2 - PubMed:30197295
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a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O- dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO2 - PubMed:30197295
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an N(1)-methyladenosine in tRNA + 2-oxoglutarate + O2 = an adenosine in tRNA + formaldehyde + succinate + CO2 - PubMed:30197295
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Cofactor: Evidence: Note:
Fe(2+) ECO:0000269 | PubMed:20376003
Binds 1 Fe(2+) ion per subunit.