PDB ID: 4UWH
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JXM | (8s)-9-[(2r)-2-hydroxy-2-phenylethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4h-pyrimido[1,2-a]pyrimidin-4-one | PoSSuM | |||
NA | Sodium ion | PoSSuM |
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Download interaction data: 4UWH
Structure summary
Code : | 4UWH PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors | ||||||||||||
Release Data : | 2014-11-26 | ||||||||||||
Compound : |
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Authors : | Pasquier, B., El-Ahmad, Y., Filoche-Romme, B., Dureuil, C., Fassy, F., Abecassis, P.Y., Mathieu, M., Bertrand, T., Benard, T., Barriere, C., ElBatti, S., Letallec, J.P., Sonnefraud, V., Brollo, M., Delbarre, L., Loyau, V., Pilorge, F., Bertin, L., Richepin, P., Arigon, J., Labrosse, J.R., Clement, J., Durand, F., Combet, R., Perraut, P., Leroy, V., Gay, F., Lefrancois, D., Bretin, F., Marquette, J.P., Michot, N., Caron, A., Castell, C., Schio, L., McCort, G., Goulaouic, H., Garcia-Echeverria, C., Ronan, B. | ||||||||||||
Keywords : | TRANSFERASE, LIPID KINASE, AUTOPHAGY INHIBITOR | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.93 Å ) | ||||||||||||
Citation : |
Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
Pasquier, B.,El-Ahmad, Y.,Filoche-Romme, B.
et al.
PubMed: 25402320 |
Reaction
Chain : | A | ||||||||
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UniProt : | Q8NEB9 (PK3C3_HUMAN) | ||||||||
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