Het-PDB Navi2 (PDB: 4GQS)

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Ligands
Code	Name	Link
0XV	(4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone	PoSSuM
GOL	Glycerol	PoSSuM
HEM	Protoporphyrin ix containing Fe	PoSSuM

Download interaction data: 4GQS

Code :

Header :

OXIDOREDUCTASE

Title :

Structure of Human Microsomal Cytochrome P450 (CYP) 2C19

Release Data :

2012-11-14

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome P450 2C19	A,B,C,D	(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase
	ec: 1.14.13.-, 1.14.13.80, 1.14.13.48, 1.14.13.49 fragment: CATALYTIC DOMAIN (UNP Residues 21-490)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:668369)
	strain: ALLELIC VARIANT 1B gene: CYP2C19 expression_system_strain: DH5alpha expression_system_vector_type: PLASMID expression_system_plasmid: PCW0RI

Authors :

Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F.

Keywords :

monooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein

Exp. method :

X-RAY DIFFRACTION ( 2.87 Å )

Citation :

Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.

Reynald, R.L.,Sansen, S.,Stout, C.D. et al.
(2012) J.Biol.Chem. 287 : 44581 - 44591

Chain :	A, B, C, D
UniProt :	P33261 (CP2CJ_HUMAN)
Reaction :	(+)-(R)-limonene + NADPH + O(2) = (+)-trans- carveol + NADP(+) + H(2)O. (-)-(S)-limonene + NADPH + O(2) = (-)-trans- carveol + NADP(+) + H(2)O. (-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.

PDB ID: 4GQS