ID 4GQSA STANDARD; PRT; 477 AA. DT CONVERTED FROM PDB (SEQRES) 4GQS DE Cytochrome P450 2C19 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.250 FT #SUB 108 125 ARG A 311 328 GLU B Protein S 8 FT #SUB 108 125 ARG A 316 333 ARG B Protein S 4 FT #SUB 112 129 MET A 308 325 GLU B Protein S 2 FT #SUB 112 129 MET A 311 328 GLU B Protein S 3 FT #SUB 115 132 ARG A 304 321 ALA B Protein S 8 FT #SUB 115 132 ARG A 307 324 GLN B Protein S 2 FT #SUB 117 134 PHE A 300 317 PRO B Protein S 4 FT #SUB 117 134 PHE A 301 318 GLU B Protein A 3 FT #SUB 117 134 PHE A 304 321 ALA B Protein B 1 FT #SUB 120 137 GLY A 301 318 GLU B Protein B 1 FT #SUB 121 138 LYS A 393 410 ARG B Protein S 3 FT #SUB 240 257 ILE A 399 416 GLY B Protein S 7 FT #SUB 241 258 ASN A 393 410 ARG B Protein B 1 FT #SUB 241 258 ASN A 396 413 LEU B Protein S 4 FT #SUB 241 258 ASN A 397 414 ASP B Protein S 1 FT #SUB 241 258 ASN A 400 417 GLY B Protein S 3 FT #SUB 242 259 ASN A 393 410 ARG B Protein S 2 FT #SUB 253 270 LYS A 312 329 ARG B Protein S 1 FT #SUB 256 273 LYS A 312 329 ARG B Protein S 7 FT #SUB 323 340 GLN A 446 463 ASP B Protein S 3 FT #SUB 19 36 LEU A 26 43 LEU C Protein S 1 FT #SUB 26 43 LEU A 26 43 LEU C Protein S 2 FT #SUB 26 43 LEU A 27 44 GLN C Protein B 3 FT #SUB 39 56 ASN A 43 60 ILE C Protein A 7 FT #SUB 42 59 LYS A 42 59 LYS C Protein A 6 FT #SUB 43 60 ILE A 39 56 ASN C Protein S 6 FT #SUB 43 60 ILE A 42 59 LYS C Protein S 1 FT #SUB 43 60 ILE A 43 60 ILE C Protein S 1 FT #HET 25 42 ILE A 5 505 GOL A S 1 FT #HET 53 70 GLY A 5 505 GOL A B 1 FT #HET 80 97 ARG A 1 501 HEM A S 4 FT #HET 95 112 ILE A 1 501 HEM A A 3 FT #HET 96 113 VAL A 1 501 HEM A A 3 FT #HET 96 113 VAL A 2 502 0XV A S 6 FT #HET 97 114 PHE A 2 502 0XV A S 4 FT #HET 103 120 TRP A 1 501 HEM A S 6 FT #HET 107 124 ARG A 1 501 HEM A S 6 FT #HET 161 178 ILE A 1 501 HEM A S 1 FT #HET 188 205 ILE A 2 502 0XV A S 3 FT #HET 191 208 VAL A 2 502 0XV A S 1 FT #HET 195 212 TRP A 4 504 GOL A S 3 FT #HET 197 214 GLN A 5 505 GOL A B 2 FT #HET 198 215 ILE A 5 505 GOL A A 11 FT #HET 201 218 ASN A 5 505 GOL A S 5 FT #HET 209 226 PHE A 4 504 GOL A S 3 FT #HET 276 293 ASP A 2 502 0XV A S 2 FT #HET 277 294 LEU A 1 501 HEM A S 1 FT #HET 279 296 GLY A 2 502 0XV A B 1 FT #HET 280 297 ALA A 1 501 HEM A A 12 FT #HET 280 297 ALA A 2 502 0XV A A 4 FT #HET 281 298 GLY A 1 501 HEM A B 7 FT #HET 283 300 GLU A 2 502 0XV A S 4 FT #HET 284 301 THR A 1 501 HEM A A 9 FT #HET 284 301 THR A 2 502 0XV A S 6 FT #HET 285 302 THR A 1 501 HEM A A 4 FT #HET 288 305 THR A 1 501 HEM A S 1 FT #HET 314 331 VAL A 3 503 GOL A B 1 FT #HET 318 335 ARG A 3 503 GOL A S 4 FT #HET 339 356 GLN A 1 501 HEM A S 1 FT #HET 345 362 ILE A 2 502 0XV A S 4 FT #HET 348 365 SER A 1 501 HEM A S 5 FT #HET 349 366 LEU A 1 501 HEM A S 1 FT #HET 349 366 LEU A 2 502 0XV A S 3 FT #HET 351 368 HIS A 1 501 HEM A S 6 FT #HET 410 427 PRO A 1 501 HEM A B 3 FT #HET 411 428 PHE A 1 501 HEM A A 14 FT #HET 412 429 SER A 1 501 HEM A A 7 FT #HET 416 433 ARG A 1 501 HEM A A 17 FT #HET 418 435 CYS A 1 501 HEM A A 24 FT #HET 419 436 VAL A 1 501 HEM A A 7 FT #HET 420 437 GLY A 1 501 HEM A B 7 FT #HET 423 440 LEU A 1 501 HEM A S 1 FT #HET 424 441 ALA A 1 501 HEM A S 3 FT #HET 427 444 GLU A 1 501 HEM A S 1 FT #HET 459 476 PHE A 2 502 0XV A S 9 FT #HET 460 477 ALA A 2 502 0XV A S 1 FT DISORDER 1 11 FT DISORDER 476 477 CC SEQUENCE 464 AA (ATOM); CC LPPGPTPLPV IGNILQIDIK DVSKSLTNLS KIYGPVFTLY FGLERMVVLH GYEVVKEALI CC DLGEEFSGRG HFPLAERANR GFGIVFSNGK RWKEIRRFSL MTLRNFGMGK RSIEDRVQEE CC ARCLVEELRK TKASPCDPTF ILGCAPCNVI CSIIFQKRFD YKDQQFLNLM EKLNENIRIV CC STPWIQICNN FPTIIDYFPG THNKLLKNLA FMESDILEKV KEHQESMDIN NPRDFIDCFL CC IKMEKEKQNQ QSEFTIENLV ITAADLLGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE CC RVVGRNRSPC MQDRGHMPYT DAVVHEVQRY IDLIPTSLPH AVTCDVKFRN YLIPKGTTIL CC TSLTSVLHDN KEFPNPEMFD PRHFLDEGGN FKKSNYFMPF SAGKRICVGE GLARMELFLF CC LTFILQNFNL KSLIDPKDLD TTPVVNGFAS VPPFYQLCFI PIHH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC ATOM -----------LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC *************************************** CC SEQRES YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ATOM YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ************************************************** CC SEQRES KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ATOM KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ************************************************** CC SEQRES FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ATOM FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ************************************************** CC SEQRES NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ATOM NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ************************************************** CC SEQRES LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ATOM LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ************************************************** CC SEQRES EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ATOM EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ************************************************** CC SEQRES HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ATOM HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ************************************************** CC SEQRES NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ATOM NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ************************************************** CC SEQRES DTTPVVNGFASVPPFYQLCFIPIHHHH CC ATOM DTTPVVNGFASVPPFYQLCFIPIHH-- CC ************************* SQ SEQUENCE 477 AA; MW; CN; MAKKTSSGRG KLPPGPTPLP VIGNILQIDI KDVSKSLTNL SKIYGPVFTL YFGLERMVVL HGYEVVKEAL IDLGEEFSGR GHFPLAERAN RGFGIVFSNG KRWKEIRRFS LMTLRNFGMG KRSIEDRVQE EARCLVEELR KTKASPCDPT FILGCAPCNV ICSIIFQKRF DYKDQQFLNL MEKLNENIRI VSTPWIQICN NFPTIIDYFP GTHNKLLKNL AFMESDILEK VKEHQESMDI NNPRDFIDCF LIKMEKEKQN QQSEFTIENL VITAADLLGA GTETTSTTLR YALLLLLKHP EVTAKVQEEI ERVVGRNRSP CMQDRGHMPY TDAVVHEVQR YIDLIPTSLP HAVTCDVKFR NYLIPKGTTI LTSLTSVLHD NKEFPNPEMF DPRHFLDEGG NFKKSNYFMP FSAGKRICVG EGLARMELFL FLTFILQNFN LKSLIDPKDL DTTPVVNGFA SVPPFYQLCF IPIHHHH // ID 4GQSB STANDARD; PRT; 477 AA. DT CONVERTED FROM PDB (SEQRES) 4GQS DE Cytochrome P450 2C19 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.250 FT #SUB 300 317 PRO B 117 134 PHE A Protein A 4 FT #SUB 301 318 GLU B 117 134 PHE A Protein B 3 FT #SUB 301 318 GLU B 120 137 GLY A Protein S 1 FT #SUB 304 321 ALA B 115 132 ARG A Protein A 8 FT #SUB 304 321 ALA B 117 134 PHE A Protein S 1 FT #SUB 307 324 GLN B 115 132 ARG A Protein S 2 FT #SUB 308 325 GLU B 112 129 MET A Protein A 2 FT #SUB 311 328 GLU B 108 125 ARG A Protein S 8 FT #SUB 311 328 GLU B 112 129 MET A Protein S 3 FT #SUB 312 329 ARG B 253 270 LYS A Protein S 1 FT #SUB 312 329 ARG B 256 273 LYS A Protein S 7 FT #SUB 316 333 ARG B 108 125 ARG A Protein S 4 FT #SUB 393 410 ARG B 121 138 LYS A Protein S 3 FT #SUB 393 410 ARG B 241 258 ASN A Protein S 1 FT #SUB 393 410 ARG B 242 259 ASN A Protein S 2 FT #SUB 396 413 LEU B 241 258 ASN A Protein S 4 FT #SUB 397 414 ASP B 241 258 ASN A Protein B 1 FT #SUB 399 416 GLY B 240 257 ILE A Protein B 7 FT #SUB 400 417 GLY B 241 258 ASN A Protein B 3 FT #SUB 446 463 ASP B 323 340 GLN A Protein S 3 FT #HET 80 97 ARG B 6 501 HEM B S 5 FT #HET 95 112 ILE B 6 501 HEM B A 3 FT #HET 96 113 VAL B 7 502 0XV B S 1 FT #HET 97 114 PHE B 7 502 0XV B S 3 FT #HET 103 120 TRP B 6 501 HEM B S 4 FT #HET 107 124 ARG B 6 501 HEM B S 5 FT #HET 188 205 ILE B 7 502 0XV B S 2 FT #HET 276 293 ASP B 7 502 0XV B A 4 FT #HET 277 294 LEU B 6 501 HEM B S 2 FT #HET 279 296 GLY B 7 502 0XV B B 4 FT #HET 280 297 ALA B 6 501 HEM B A 12 FT #HET 280 297 ALA B 7 502 0XV B A 6 FT #HET 281 298 GLY B 6 501 HEM B B 6 FT #HET 283 300 GLU B 7 502 0XV B S 2 FT #HET 284 301 THR B 6 501 HEM B A 8 FT #HET 284 301 THR B 7 502 0XV B S 3 FT #HET 285 302 THR B 6 501 HEM B A 4 FT #HET 288 305 THR B 6 501 HEM B S 2 FT #HET 344 361 LEU B 6 501 HEM B S 1 FT #HET 345 362 ILE B 6 501 HEM B S 3 FT #HET 345 362 ILE B 7 502 0XV B S 3 FT #HET 348 365 SER B 6 501 HEM B S 4 FT #HET 349 366 LEU B 7 502 0XV B S 2 FT #HET 351 368 HIS B 6 501 HEM B S 6 FT #HET 410 427 PRO B 6 501 HEM B B 3 FT #HET 411 428 PHE B 6 501 HEM B A 12 FT #HET 412 429 SER B 6 501 HEM B A 8 FT #HET 416 433 ARG B 6 501 HEM B A 21 FT #HET 418 435 CYS B 6 501 HEM B A 23 FT #HET 419 436 VAL B 6 501 HEM B A 6 FT #HET 420 437 GLY B 6 501 HEM B B 6 FT #HET 423 440 LEU B 6 501 HEM B S 1 FT #HET 424 441 ALA B 6 501 HEM B A 3 FT #HET 427 444 GLU B 6 501 HEM B S 1 FT #HET 459 476 PHE B 7 502 0XV B S 4 FT #HET 460 477 ALA B 7 502 0XV B S 2 FT DISORDER 1 11 FT DISORDER 202 207 FT DISORDER 474 477 CC SEQUENCE 456 AA (ATOM); CC LPPGPTPLPV IGNILQIDIK DVSKSLTNLS KIYGPVFTLY FGLERMVVLH GYEVVKEALI CC DLGEEFSGRG HFPLAERANR GFGIVFSNGK RWKEIRRFSL MTLRNFGMGK RSIEDRVQEE CC ARCLVEELRK TKASPCDPTF ILGCAPCNVI CSIIFQKRFD YKDQQFLNLM EKLNENIRIV CC STPWIQICNN YFPGTHNKLL KNLAFMESDI LEKVKEHQES MDINNPRDFI DCFLIKMEKE CC KQNQQSEFTI ENLVITAADL LGAGTETTST TLRYALLLLL KHPEVTAKVQ EEIERVVGRN CC RSPCMQDRGH MPYTDAVVHE VQRYIDLIPT SLPHAVTCDV KFRNYLIPKG TTILTSLTSV CC LHDNKEFPNP EMFDPRHFLD EGGNFKKSNY FMPFSAGKRI CVGEGLARME LFLFLTFILQ CC NFNLKSLIDP KDLDTTPVVN GFASVPPFYQ LCFIPI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC ATOM -----------LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC *************************************** CC SEQRES YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ATOM YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ************************************************** CC SEQRES KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ATOM KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ************************************************** CC SEQRES FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ATOM FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ************************************************** CC SEQRES NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ATOM N------YFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC * ******************************************* CC SEQRES LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ATOM LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ************************************************** CC SEQRES EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ATOM EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ************************************************** CC SEQRES HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ATOM HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ************************************************** CC SEQRES NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ATOM NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ************************************************** CC SEQRES DTTPVVNGFASVPPFYQLCFIPIHHHH CC ATOM DTTPVVNGFASVPPFYQLCFIPI---- CC *********************** SQ SEQUENCE 477 AA; MW; CN; MAKKTSSGRG KLPPGPTPLP VIGNILQIDI KDVSKSLTNL SKIYGPVFTL YFGLERMVVL HGYEVVKEAL IDLGEEFSGR GHFPLAERAN RGFGIVFSNG KRWKEIRRFS LMTLRNFGMG KRSIEDRVQE EARCLVEELR KTKASPCDPT FILGCAPCNV ICSIIFQKRF DYKDQQFLNL MEKLNENIRI VSTPWIQICN NFPTIIDYFP GTHNKLLKNL AFMESDILEK VKEHQESMDI NNPRDFIDCF LIKMEKEKQN QQSEFTIENL VITAADLLGA GTETTSTTLR YALLLLLKHP EVTAKVQEEI ERVVGRNRSP CMQDRGHMPY TDAVVHEVQR YIDLIPTSLP HAVTCDVKFR NYLIPKGTTI LTSLTSVLHD NKEFPNPEMF DPRHFLDEGG NFKKSNYFMP FSAGKRICVG EGLARMELFL FLTFILQNFN LKSLIDPKDL DTTPVVNGFA SVPPFYQLCF IPIHHHH // ID 4GQSC STANDARD; PRT; 477 AA. DT CONVERTED FROM PDB (SEQRES) 4GQS DE Cytochrome P450 2C19 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.250 FT #SUB 26 43 LEU C 19 36 LEU A Protein S 1 FT #SUB 26 43 LEU C 26 43 LEU A Protein A 2 FT #SUB 27 44 GLN C 26 43 LEU A Protein S 3 FT #SUB 39 56 ASN C 43 60 ILE A Protein A 6 FT #SUB 42 59 LYS C 42 59 LYS A Protein A 6 FT #SUB 42 59 LYS C 43 60 ILE A Protein S 1 FT #SUB 43 60 ILE C 39 56 ASN A Protein S 7 FT #SUB 43 60 ILE C 43 60 ILE A Protein S 1 FT #SUB 76 93 GLU C 323 340 GLN D Protein S 2 FT #HET 80 97 ARG C 8 501 HEM C S 5 FT #HET 95 112 ILE C 8 501 HEM C A 4 FT #HET 96 113 VAL C 8 501 HEM C A 4 FT #HET 96 113 VAL C 9 502 0XV C S 2 FT #HET 97 114 PHE C 9 502 0XV C S 6 FT #HET 103 120 TRP C 8 501 HEM C S 5 FT #HET 107 124 ARG C 8 501 HEM C S 4 FT #HET 161 178 ILE C 8 501 HEM C S 2 FT #HET 188 205 ILE C 9 502 0XV C S 1 FT #HET 191 208 VAL C 9 502 0XV C S 1 FT #HET 276 293 ASP C 9 502 0XV C S 1 FT #HET 279 296 GLY C 9 502 0XV C B 1 FT #HET 280 297 ALA C 8 501 HEM C A 13 FT #HET 280 297 ALA C 9 502 0XV C A 5 FT #HET 281 298 GLY C 8 501 HEM C B 7 FT #HET 283 300 GLU C 9 502 0XV C S 3 FT #HET 284 301 THR C 8 501 HEM C A 9 FT #HET 284 301 THR C 9 502 0XV C S 5 FT #HET 285 302 THR C 8 501 HEM C A 3 FT #HET 288 305 THR C 8 501 HEM C S 2 FT #HET 339 356 GLN C 8 501 HEM C S 1 FT #HET 345 362 ILE C 8 501 HEM C S 1 FT #HET 345 362 ILE C 9 502 0XV C S 3 FT #HET 348 365 SER C 8 501 HEM C S 4 FT #HET 349 366 LEU C 9 502 0XV C S 2 FT #HET 351 368 HIS C 8 501 HEM C S 6 FT #HET 374 391 LEU C 8 501 HEM C S 1 FT #HET 410 427 PRO C 8 501 HEM C B 3 FT #HET 411 428 PHE C 8 501 HEM C A 10 FT #HET 412 429 SER C 8 501 HEM C A 7 FT #HET 416 433 ARG C 8 501 HEM C A 20 FT #HET 418 435 CYS C 8 501 HEM C A 22 FT #HET 419 436 VAL C 8 501 HEM C A 5 FT #HET 420 437 GLY C 8 501 HEM C B 5 FT #HET 423 440 LEU C 8 501 HEM C S 1 FT #HET 424 441 ALA C 8 501 HEM C S 2 FT #HET 427 444 GLU C 8 501 HEM C S 1 FT #HET 459 476 PHE C 9 502 0XV C S 5 FT DISORDER 1 11 FT DISORDER 474 477 CC SEQUENCE 462 AA (ATOM); CC LPPGPTPLPV IGNILQIDIK DVSKSLTNLS KIYGPVFTLY FGLERMVVLH GYEVVKEALI CC DLGEEFSGRG HFPLAERANR GFGIVFSNGK RWKEIRRFSL MTLRNFGMGK RSIEDRVQEE CC ARCLVEELRK TKASPCDPTF ILGCAPCNVI CSIIFQKRFD YKDQQFLNLM EKLNENIRIV CC STPWIQICNN FPTIIDYFPG THNKLLKNLA FMESDILEKV KEHQESMDIN NPRDFIDCFL CC IKMEKEKQNQ QSEFTIENLV ITAADLLGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE CC RVVGRNRSPC MQDRGHMPYT DAVVHEVQRY IDLIPTSLPH AVTCDVKFRN YLIPKGTTIL CC TSLTSVLHDN KEFPNPEMFD PRHFLDEGGN FKKSNYFMPF SAGKRICVGE GLARMELFLF CC LTFILQNFNL KSLIDPKDLD TTPVVNGFAS VPPFYQLCFI PI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC ATOM -----------LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC *************************************** CC SEQRES YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ATOM YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ************************************************** CC SEQRES KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ATOM KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ************************************************** CC SEQRES FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ATOM FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ************************************************** CC SEQRES NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ATOM NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ************************************************** CC SEQRES LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ATOM LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ************************************************** CC SEQRES EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ATOM EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ************************************************** CC SEQRES HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ATOM HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ************************************************** CC SEQRES NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ATOM NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ************************************************** CC SEQRES DTTPVVNGFASVPPFYQLCFIPIHHHH CC ATOM DTTPVVNGFASVPPFYQLCFIPI---- CC *********************** SQ SEQUENCE 477 AA; MW; CN; MAKKTSSGRG KLPPGPTPLP VIGNILQIDI KDVSKSLTNL SKIYGPVFTL YFGLERMVVL HGYEVVKEAL IDLGEEFSGR GHFPLAERAN RGFGIVFSNG KRWKEIRRFS LMTLRNFGMG KRSIEDRVQE EARCLVEELR KTKASPCDPT FILGCAPCNV ICSIIFQKRF DYKDQQFLNL MEKLNENIRI VSTPWIQICN NFPTIIDYFP GTHNKLLKNL AFMESDILEK VKEHQESMDI NNPRDFIDCF LIKMEKEKQN QQSEFTIENL VITAADLLGA GTETTSTTLR YALLLLLKHP EVTAKVQEEI ERVVGRNRSP CMQDRGHMPY TDAVVHEVQR YIDLIPTSLP HAVTCDVKFR NYLIPKGTTI LTSLTSVLHD NKEFPNPEMF DPRHFLDEGG NFKKSNYFMP FSAGKRICVG EGLARMELFL FLTFILQNFN LKSLIDPKDL DTTPVVNGFA SVPPFYQLCF IPIHHHH // ID 4GQSD STANDARD; PRT; 477 AA. DT CONVERTED FROM PDB (SEQRES) 4GQS DE Cytochrome P450 2C19 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.870 CC R-Factor 0.250 FT #SUB 323 340 GLN D 76 93 GLU C Protein S 2 FT #HET 80 97 ARG D 10 501 HEM D S 6 FT #HET 95 112 ILE D 10 501 HEM D A 5 FT #HET 96 113 VAL D 10 501 HEM D A 6 FT #HET 97 114 PHE D 11 502 0XV D S 3 FT #HET 103 120 TRP D 10 501 HEM D S 5 FT #HET 107 124 ARG D 10 501 HEM D S 4 FT #HET 188 205 ILE D 11 502 0XV D S 2 FT #HET 276 293 ASP D 11 502 0XV D S 1 FT #HET 277 294 LEU D 10 501 HEM D S 3 FT #HET 280 297 ALA D 10 501 HEM D A 8 FT #HET 280 297 ALA D 11 502 0XV D A 7 FT #HET 281 298 GLY D 10 501 HEM D B 4 FT #HET 283 300 GLU D 11 502 0XV D S 1 FT #HET 284 301 THR D 10 501 HEM D A 11 FT #HET 284 301 THR D 11 502 0XV D S 3 FT #HET 285 302 THR D 10 501 HEM D A 6 FT #HET 288 305 THR D 10 501 HEM D S 1 FT #HET 339 356 GLN D 10 501 HEM D S 1 FT #HET 344 361 LEU D 10 501 HEM D S 1 FT #HET 345 362 ILE D 10 501 HEM D S 2 FT #HET 345 362 ILE D 11 502 0XV D S 5 FT #HET 348 365 SER D 10 501 HEM D S 3 FT #HET 349 366 LEU D 11 502 0XV D S 2 FT #HET 351 368 HIS D 10 501 HEM D S 7 FT #HET 410 427 PRO D 10 501 HEM D B 2 FT #HET 411 428 PHE D 10 501 HEM D A 14 FT #HET 412 429 SER D 10 501 HEM D A 8 FT #HET 416 433 ARG D 10 501 HEM D A 14 FT #HET 418 435 CYS D 10 501 HEM D A 21 FT #HET 419 436 VAL D 10 501 HEM D A 3 FT #HET 420 437 GLY D 10 501 HEM D B 5 FT #HET 424 441 ALA D 10 501 HEM D S 2 FT #HET 428 445 LEU D 10 501 HEM D S 1 FT #HET 459 476 PHE D 11 502 0XV D S 2 FT #HET 460 477 ALA D 11 502 0XV D S 2 FT DISORDER 1 11 FT DISORDER 115 124 FT DISORDER 474 477 CC SEQUENCE 452 AA (ATOM); CC LPPGPTPLPV IGNILQIDIK DVSKSLTNLS KIYGPVFTLY FGLERMVVLH GYEVVKEALI CC DLGEEFSGRG HFPLAERANR GFGIVFSNGK RWKEIRRFSL MTLEDRVQEE ARCLVEELRK CC TKASPCDPTF ILGCAPCNVI CSIIFQKRFD YKDQQFLNLM EKLNENIRIV STPWIQICNN CC FPTIIDYFPG THNKLLKNLA FMESDILEKV KEHQESMDIN NPRDFIDCFL IKMEKEKQNQ CC QSEFTIENLV ITAADLLGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVVGRNRSPC CC MQDRGHMPYT DAVVHEVQRY IDLIPTSLPH AVTCDVKFRN YLIPKGTTIL TSLTSVLHDN CC KEFPNPEMFD PRHFLDEGGN FKKSNYFMPF SAGKRICVGE GLARMELFLF LTFILQNFNL CC KSLIDPKDLD TTPVVNGFAS VPPFYQLCFI PI CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC ATOM -----------LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTL CC *************************************** CC SEQRES YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ATOM YFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNG CC ************************************************** CC SEQRES KRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT CC ATOM KRWKEIRRFSLMTL----------EDRVQEEARCLVEELRKTKASPCDPT CC ************** ************************** CC SEQRES FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ATOM FILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICN CC ************************************************** CC SEQRES NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ATOM NFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCF CC ************************************************** CC SEQRES LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ATOM LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP CC ************************************************** CC SEQRES EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ATOM EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLP CC ************************************************** CC SEQRES HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ATOM HAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG CC ************************************************** CC SEQRES NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ATOM NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL CC ************************************************** CC SEQRES DTTPVVNGFASVPPFYQLCFIPIHHHH CC ATOM DTTPVVNGFASVPPFYQLCFIPI---- CC *********************** SQ SEQUENCE 477 AA; MW; CN; MAKKTSSGRG KLPPGPTPLP VIGNILQIDI KDVSKSLTNL SKIYGPVFTL YFGLERMVVL HGYEVVKEAL IDLGEEFSGR GHFPLAERAN RGFGIVFSNG KRWKEIRRFS LMTLRNFGMG KRSIEDRVQE EARCLVEELR KTKASPCDPT FILGCAPCNV ICSIIFQKRF DYKDQQFLNL MEKLNENIRI VSTPWIQICN NFPTIIDYFP GTHNKLLKNL AFMESDILEK VKEHQESMDI NNPRDFIDCF LIKMEKEKQN QQSEFTIENL VITAADLLGA GTETTSTTLR YALLLLLKHP EVTAKVQEEI ERVVGRNRSP CMQDRGHMPY TDAVVHEVQR YIDLIPTSLP HAVTCDVKFR NYLIPKGTTI LTSLTSVLHD NKEFPNPEMF DPRHFLDEGG NFKKSNYFMP FSAGKRICVG EGLARMELFL FLTFILQNFN LKSLIDPKDL DTTPVVNGFA SVPPFYQLCF IPIHHHH //