Brand  (β version)

PDB ID: 4G9C

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Ligands
Code Name Style Show Link
0WP 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-N-(3-methoxy-2h-pyrazolo[3,4-B]pyridin-5-yl)benzamide PoSSuM
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Structure summary

Code : 4G9C   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human B-Raf Kinase Domain bound to a Type II Pyrazolopyridine Inhibitor
Release Data : 2012-11-14
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase B-raf A,B Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
ec: 2.7.11.1
fragment: Kinase Domain (UNP residues 432-726)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: BRAF, BRAF1, RAFB1
expression_system_strain: High Five
Authors : Voegtli, W.C., Sturgis, H.L.
Keywords : DFG-out, Inhibitor, Type II, Transferase, Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.50 Å )
Citation :

Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors.

Wenglowsky, S.,Moreno, D.,Laird, E.R.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 6237 - 6241

PubMed: 22954737
DOI: 10.1016/j.bmcl.2012.08.007

Reaction

Chain : A, B
UniProt : P15056 (BRAF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:21441910, PubMed:29433126
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:21441910
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