Brand  (β version)

PDB ID: 4FZ6

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Ligands
Code Name Style Show Link
0VG N-{6-[(2s)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-B]pyridazin-8-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4FZ6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-B]pyridazin-8-yl)-amine
Release Data : 2013-01-30
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase SYK A Spleen tyrosine kinase, p72-Syk
ec: 2.7.10.2
fragment: RESIDUES 356-635, PROTEIN KINASE DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SYK
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Kuglstatter, A., Slade, M.
Keywords : kinase inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Rational design of highly selective spleen tyrosine kinase inhibitors.

Lucas, M.C.,Goldstein, D.M.,Hermann, J.C.  et al.
(2012)  J.Med.Chem.  55 : 10414 - 10423

PubMed: 23151054
DOI: 10.1021/jm301367c

Reaction

Chain : A
UniProt : P43405 (KSYK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:33782605, PubMed:34634301
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