PDB ID: 4FSE
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
0VA | N-[N-(4-amino-3,5-dichlorobenzyl)carbamimidoyl]-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide | PoSSuM | |||
IOD | Iodide ion | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|
Download interaction data: 4FSE
Structure summary
Code : | 4FSE PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | HYDROLASE/INHIBITOR | ||||||||||||
Title : | crystal structure of beta-site app-cleaving enzyme 1 (bace-wt) complex with N-(N-(4-amino-3,5- dichlorobenzyl)carbamimidoyl)-3-(4-methoxyphenyl)-5- methyl-4-isothiazolecarboxamide | ||||||||||||
Release Data : | 2012-10-10 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Muckelbauer, J.K. | ||||||||||||
Keywords : | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.6500 Å ) | ||||||||||||
Citation : |
Acyl guanidine inhibitors of beta-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis
Gerritz, S.W.,Zhai, W.,Shi, S.
et al.
PubMed: 23030502 |
Reaction
Chain : | A, B, D, E | ||||||||
---|---|---|---|---|---|---|---|---|---|
UniProt : | P56817 (BACE1_HUMAN) | ||||||||
|