ID 4FSEA STANDARD; PRT; 455 AA. DT CONVERTED FROM PDB (SEQRES) 4FSE DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.650 CC R-Factor 0.220 FT #SUB 267 253 ARG A 427 413 PHE B Protein S 8 FT #SUB 271 257 ASN A 271 257 ASN B Protein A 7 FT #SUB 272 258 GLY A 340 326 ASN B Protein B 3 FT #SUB 273 259 GLN A 316 302 THR B Protein S 2 FT #SUB 273 259 GLN A 340 326 ASN B Protein A 8 FT #SUB 273 259 GLN A 341 327 ILE B Protein S 3 FT #SUB 274 260 ASP A 340 326 ASN B Protein A 6 FT #SUB 316 302 THR A 273 259 GLN B Protein S 2 FT #SUB 340 326 ASN A 272 258 GLY B Protein A 4 FT #SUB 340 326 ASN A 273 259 GLN B Protein A 7 FT #SUB 340 326 ASN A 274 260 ASP B Protein S 7 FT #SUB 341 327 ILE A 273 259 GLN B Protein A 3 FT #SUB 348 334 TYR A 427 413 PHE B Protein S 2 FT #SUB 359 345 ARG A 427 413 PHE B Protein S 4 FT #SUB 426 412 GLU A 436 422 PHE B Protein A 5 FT #SUB 426 412 GLU A 437 423 VAL B Protein S 6 FT #SUB 427 413 PHE A 267 253 ARG B Protein S 10 FT #SUB 427 413 PHE A 269 255 GLU B Protein S 1 FT #SUB 427 413 PHE A 348 334 TYR B Protein S 5 FT #SUB 427 413 PHE A 359 345 ARG B Protein B 5 FT #SUB 427 413 PHE A 436 422 PHE B Protein A 2 FT #SUB 436 422 PHE A 426 412 GLU B Protein S 2 FT #SUB 436 422 PHE A 427 413 PHE B Protein S 1 FT #SUB 437 423 VAL A 426 412 GLU B Protein B 1 FT #HET 92 78 LEU A 1 501 0VA A S 1 FT #HET 94 80 ASP A 1 501 0VA A S 6 FT #HET 96 82 GLY A 1 501 0VA A B 1 FT #HET 133 119 TYR A 1 501 0VA A S 12 FT #HET 135 121 GLN A 1 501 0VA A A 19 FT #HET 136 122 GLY A 1 501 0VA A B 4 FT #HET 137 123 LYS A 1 501 0VA A B 1 FT #HET 137 123 LYS A 3 503 IOD A S 1 FT #HET 169 155 LYS A 1 501 0VA A B 1 FT #HET 170 156 PHE A 1 501 0VA A A 6 FT #HET 177 163 TRP A 1 501 0VA A S 2 FT #HET 260 246 TYR A 1 501 0VA A S 3 FT #HET 288 274 ILE A 1 501 0VA A S 2 FT #HET 290 276 ASP A 1 501 0VA A S 12 FT #HET 292 278 GLY A 1 501 0VA A B 5 FT #HET 293 279 THR A 1 501 0VA A S 5 FT #HET 293 279 THR A 2 502 IOD A S 1 FT #HET 295 281 ASN A 2 502 IOD A A 4 FT #HET 297 283 ARG A 1 501 0VA A S 8 FT #HET 297 283 ARG A 2 502 IOD A S 1 FT #HET 391 377 THR A 1 501 0VA A S 2 FT #HET 394 380 VAL A 1 501 0VA A S 2 FT DISORDER 1 60 FT DISORDER 448 455 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASMTGGQQMGRGSAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDE CC ATOM -------------------------------------------------- CC CC SEQRES EPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC ATOM ----------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC **************************************** CC SEQRES AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ATOM AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ************************************************** CC SEQRES HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ATOM HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ************************************************** CC SEQRES SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ATOM SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ************************************************** CC SEQRES WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ATOM WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ************************************************** CC SEQRES KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ATOM KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ************************************************** CC SEQRES GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ATOM GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ************************************************** CC SEQRES EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQ CC ATOM EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN--- CC *********************************************** CC SEQRES TDEST CC ATOM ----- CC SQ SEQUENCE 455 AA; MW; CN; MASMTGGQQM GRGSAGVLPA HGTQHGIRLP LRSGLGGAPL GLRLPRETDE EPEEPGRRGS FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CHVHDEFRTA AVEGPFVTLD MEDCGYNIPQ TDEST // ID 4FSEB STANDARD; PRT; 455 AA. DT CONVERTED FROM PDB (SEQRES) 4FSE DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.650 CC R-Factor 0.220 FT #SUB 267 253 ARG B 427 413 PHE A Protein S 10 FT #SUB 269 255 GLU B 427 413 PHE A Protein S 1 FT #SUB 271 257 ASN B 271 257 ASN A Protein A 7 FT #SUB 272 258 GLY B 340 326 ASN A Protein B 4 FT #SUB 273 259 GLN B 316 302 THR A Protein S 2 FT #SUB 273 259 GLN B 340 326 ASN A Protein A 7 FT #SUB 273 259 GLN B 341 327 ILE A Protein S 3 FT #SUB 274 260 ASP B 340 326 ASN A Protein A 7 FT #SUB 316 302 THR B 273 259 GLN A Protein S 2 FT #SUB 340 326 ASN B 272 258 GLY A Protein A 3 FT #SUB 340 326 ASN B 273 259 GLN A Protein A 8 FT #SUB 340 326 ASN B 274 260 ASP A Protein S 6 FT #SUB 341 327 ILE B 273 259 GLN A Protein A 3 FT #SUB 348 334 TYR B 427 413 PHE A Protein S 5 FT #SUB 359 345 ARG B 427 413 PHE A Protein S 5 FT #SUB 426 412 GLU B 436 422 PHE A Protein B 2 FT #SUB 426 412 GLU B 437 423 VAL A Protein S 1 FT #SUB 427 413 PHE B 267 253 ARG A Protein S 8 FT #SUB 427 413 PHE B 348 334 TYR A Protein S 2 FT #SUB 427 413 PHE B 359 345 ARG A Protein B 4 FT #SUB 427 413 PHE B 436 422 PHE A Protein S 1 FT #SUB 436 422 PHE B 426 412 GLU A Protein A 5 FT #SUB 436 422 PHE B 427 413 PHE A Protein S 2 FT #SUB 437 423 VAL B 426 412 GLU A Protein B 6 FT #SUB 207 193 HIS B 331 317 CYS D Protein S 2 FT #SUB 207 193 HIS B 333 319 GLN D Protein S 2 FT #SUB 207 193 HIS B 379 365 ASP D Protein S 5 FT #HET 92 78 LEU B 4 501 0VA B S 1 FT #HET 94 80 ASP B 4 501 0VA B S 7 FT #HET 96 82 GLY B 4 501 0VA B B 3 FT #HET 133 119 TYR B 4 501 0VA B S 12 FT #HET 134 120 THR B 4 501 0VA B S 2 FT #HET 135 121 GLN B 4 501 0VA B A 16 FT #HET 136 122 GLY B 4 501 0VA B B 4 FT #HET 137 123 LYS B 4 501 0VA B B 1 FT #HET 137 123 LYS B 6 503 IOD B S 2 FT #HET 169 155 LYS B 4 501 0VA B B 1 FT #HET 170 156 PHE B 4 501 0VA B A 5 FT #HET 177 163 TRP B 4 501 0VA B S 2 FT #HET 260 246 TYR B 4 501 0VA B S 2 FT #HET 288 274 ILE B 4 501 0VA B S 2 FT #HET 290 276 ASP B 4 501 0VA B S 13 FT #HET 292 278 GLY B 4 501 0VA B B 5 FT #HET 293 279 THR B 4 501 0VA B S 5 FT #HET 295 281 ASN B 5 502 IOD B A 4 FT #HET 297 283 ARG B 4 501 0VA B S 13 FT #HET 297 283 ARG B 5 502 IOD B S 1 FT #HET 391 377 THR B 4 501 0VA B S 2 FT #HET 394 380 VAL B 4 501 0VA B S 2 FT DISORDER 1 60 FT DISORDER 448 455 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASMTGGQQMGRGSAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDE CC ATOM -------------------------------------------------- CC CC SEQRES EPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC ATOM ----------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC **************************************** CC SEQRES AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ATOM AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ************************************************** CC SEQRES HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ATOM HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ************************************************** CC SEQRES SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ATOM SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ************************************************** CC SEQRES WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ATOM WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ************************************************** CC SEQRES KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ATOM KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ************************************************** CC SEQRES GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ATOM GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ************************************************** CC SEQRES EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQ CC ATOM EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN--- CC *********************************************** CC SEQRES TDEST CC ATOM ----- CC SQ SEQUENCE 455 AA; MW; CN; MASMTGGQQM GRGSAGVLPA HGTQHGIRLP LRSGLGGAPL GLRLPRETDE EPEEPGRRGS FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CHVHDEFRTA AVEGPFVTLD MEDCGYNIPQ TDEST // ID 4FSED STANDARD; PRT; 455 AA. DT CONVERTED FROM PDB (SEQRES) 4FSE DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.650 CC R-Factor 0.220 FT #SUB 331 317 CYS D 207 193 HIS B Protein B 2 FT #SUB 333 319 GLN D 207 193 HIS B Protein S 2 FT #SUB 379 365 ASP D 207 193 HIS B Protein S 5 FT #SUB 267 253 ARG D 427 413 PHE E Protein S 3 FT #SUB 271 257 ASN D 271 257 ASN E Protein A 8 FT #SUB 272 258 GLY D 340 326 ASN E Protein B 3 FT #SUB 273 259 GLN D 313 299 ALA E Protein S 1 FT #SUB 273 259 GLN D 316 302 THR E Protein S 1 FT #SUB 273 259 GLN D 340 326 ASN E Protein A 6 FT #SUB 273 259 GLN D 341 327 ILE E Protein S 3 FT #SUB 274 260 ASP D 340 326 ASN E Protein A 5 FT #SUB 313 299 ALA D 273 259 GLN E Protein B 1 FT #SUB 316 302 THR D 273 259 GLN E Protein S 2 FT #SUB 340 326 ASN D 272 258 GLY E Protein A 4 FT #SUB 340 326 ASN D 273 259 GLN E Protein A 7 FT #SUB 340 326 ASN D 274 260 ASP E Protein S 6 FT #SUB 341 327 ILE D 273 259 GLN E Protein A 3 FT #SUB 348 334 TYR D 427 413 PHE E Protein S 1 FT #SUB 359 345 ARG D 427 413 PHE E Protein S 4 FT #SUB 426 412 GLU D 436 422 PHE E Protein A 6 FT #SUB 426 412 GLU D 437 423 VAL E Protein S 5 FT #SUB 427 413 PHE D 267 253 ARG E Protein S 12 FT #SUB 427 413 PHE D 348 334 TYR E Protein S 2 FT #SUB 427 413 PHE D 359 345 ARG E Protein B 5 FT #SUB 427 413 PHE D 436 422 PHE E Protein A 2 FT #SUB 436 422 PHE D 426 412 GLU E Protein A 6 FT #SUB 436 422 PHE D 427 413 PHE E Protein S 3 FT #SUB 437 423 VAL D 426 412 GLU E Protein A 9 FT #HET 92 78 LEU D 7 501 0VA D S 1 FT #HET 94 80 ASP D 7 501 0VA D S 6 FT #HET 96 82 GLY D 7 501 0VA D B 1 FT #HET 133 119 TYR D 7 501 0VA D S 11 FT #HET 134 120 THR D 7 501 0VA D S 2 FT #HET 135 121 GLN D 7 501 0VA D S 17 FT #HET 136 122 GLY D 7 501 0VA D B 4 FT #HET 137 123 LYS D 7 501 0VA D B 1 FT #HET 166 152 GLU D 9 503 IOD D B 1 FT #HET 169 155 LYS D 7 501 0VA D B 1 FT #HET 170 156 PHE D 7 501 0VA D A 9 FT #HET 172 158 ILE D 7 501 0VA D S 1 FT #HET 177 163 TRP D 7 501 0VA D S 2 FT #HET 260 246 TYR D 7 501 0VA D S 2 FT #HET 288 274 ILE D 7 501 0VA D S 2 FT #HET 290 276 ASP D 7 501 0VA D S 13 FT #HET 292 278 GLY D 7 501 0VA D B 5 FT #HET 293 279 THR D 7 501 0VA D S 6 FT #HET 293 279 THR D 8 502 IOD D S 1 FT #HET 295 281 ASN D 8 502 IOD D A 3 FT #HET 297 283 ARG D 7 501 0VA D S 13 FT #HET 391 377 THR D 7 501 0VA D S 2 FT #HET 394 380 VAL D 7 501 0VA D S 2 FT DISORDER 1 60 FT DISORDER 448 455 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASMTGGQQMGRGSAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDE CC ATOM -------------------------------------------------- CC CC SEQRES EPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC ATOM ----------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC **************************************** CC SEQRES AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ATOM AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ************************************************** CC SEQRES HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ATOM HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ************************************************** CC SEQRES SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ATOM SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ************************************************** CC SEQRES WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ATOM WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ************************************************** CC SEQRES KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ATOM KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ************************************************** CC SEQRES GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ATOM GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ************************************************** CC SEQRES EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQ CC ATOM EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN--- CC *********************************************** CC SEQRES TDEST CC ATOM ----- CC SQ SEQUENCE 455 AA; MW; CN; MASMTGGQQM GRGSAGVLPA HGTQHGIRLP LRSGLGGAPL GLRLPRETDE EPEEPGRRGS FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CHVHDEFRTA AVEGPFVTLD MEDCGYNIPQ TDEST // ID 4FSEE STANDARD; PRT; 455 AA. DT CONVERTED FROM PDB (SEQRES) 4FSE DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.650 CC R-Factor 0.220 FT #SUB 267 253 ARG E 427 413 PHE D Protein S 12 FT #SUB 271 257 ASN E 271 257 ASN D Protein A 8 FT #SUB 272 258 GLY E 340 326 ASN D Protein B 4 FT #SUB 273 259 GLN E 313 299 ALA D Protein S 1 FT #SUB 273 259 GLN E 316 302 THR D Protein S 2 FT #SUB 273 259 GLN E 340 326 ASN D Protein A 7 FT #SUB 273 259 GLN E 341 327 ILE D Protein S 3 FT #SUB 274 260 ASP E 340 326 ASN D Protein A 6 FT #SUB 313 299 ALA E 273 259 GLN D Protein B 1 FT #SUB 316 302 THR E 273 259 GLN D Protein S 1 FT #SUB 340 326 ASN E 272 258 GLY D Protein A 3 FT #SUB 340 326 ASN E 273 259 GLN D Protein A 6 FT #SUB 340 326 ASN E 274 260 ASP D Protein S 5 FT #SUB 341 327 ILE E 273 259 GLN D Protein A 3 FT #SUB 348 334 TYR E 427 413 PHE D Protein S 2 FT #SUB 359 345 ARG E 427 413 PHE D Protein S 5 FT #SUB 426 412 GLU E 436 422 PHE D Protein A 6 FT #SUB 426 412 GLU E 437 423 VAL D Protein S 9 FT #SUB 427 413 PHE E 267 253 ARG D Protein S 3 FT #SUB 427 413 PHE E 348 334 TYR D Protein S 1 FT #SUB 427 413 PHE E 359 345 ARG D Protein B 4 FT #SUB 427 413 PHE E 436 422 PHE D Protein A 3 FT #SUB 436 422 PHE E 426 412 GLU D Protein A 6 FT #SUB 436 422 PHE E 427 413 PHE D Protein S 2 FT #SUB 437 423 VAL E 426 412 GLU D Protein B 5 FT #HET 92 78 LEU E 10 501 0VA E S 2 FT #HET 94 80 ASP E 10 501 0VA E S 7 FT #HET 96 82 GLY E 10 501 0VA E B 1 FT #HET 133 119 TYR E 10 501 0VA E S 17 FT #HET 134 120 THR E 10 501 0VA E S 2 FT #HET 135 121 GLN E 10 501 0VA E S 15 FT #HET 136 122 GLY E 10 501 0VA E B 4 FT #HET 137 123 LYS E 12 503 IOD E S 1 FT #HET 166 152 GLU E 12 503 IOD E B 1 FT #HET 169 155 LYS E 10 501 0VA E B 1 FT #HET 170 156 PHE E 10 501 0VA E A 5 FT #HET 177 163 TRP E 10 501 0VA E S 2 FT #HET 260 246 TYR E 10 501 0VA E S 3 FT #HET 288 274 ILE E 10 501 0VA E S 2 FT #HET 290 276 ASP E 10 501 0VA E S 13 FT #HET 292 278 GLY E 10 501 0VA E B 5 FT #HET 293 279 THR E 10 501 0VA E S 3 FT #HET 295 281 ASN E 11 502 IOD E A 3 FT #HET 297 283 ARG E 10 501 0VA E S 12 FT #HET 297 283 ARG E 11 502 IOD E S 1 FT #HET 391 377 THR E 10 501 0VA E S 2 FT #HET 394 380 VAL E 10 501 0VA E S 2 FT DISORDER 1 60 FT DISORDER 448 455 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASMTGGQQMGRGSAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDE CC ATOM -------------------------------------------------- CC CC SEQRES EPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC ATOM ----------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNF CC **************************************** CC SEQRES AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ATOM AVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIP CC ************************************************** CC SEQRES HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ATOM HGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFD CC ************************************************** CC SEQRES SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ATOM SLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSL CC ************************************************** CC SEQRES WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ATOM WYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPK CC ************************************************** CC SEQRES KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ATOM KVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLM CC ************************************************** CC SEQRES GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ATOM GEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIM CC ************************************************** CC SEQRES EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQ CC ATOM EGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN--- CC *********************************************** CC SEQRES TDEST CC ATOM ----- CC SQ SEQUENCE 455 AA; MW; CN; MASMTGGQQM GRGSAGVLPA HGTQHGIRLP LRSGLGGAPL GLRLPRETDE EPEEPGRRGS FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CHVHDEFRTA AVEGPFVTLD MEDCGYNIPQ TDEST //