PDB ID: 4FC0
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0T2 | 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-N-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-B]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide | PoSSuM |
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Download interaction data: 4FC0
Structure summary
Code : | 4FC0 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor | ||||||||||||
Release Data : | 2014-01-08 | ||||||||||||
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Authors : | Yano, J.K., Aertgeerts, K. | ||||||||||||
Keywords : | human serine/theronine protein Kinase, kinase drug complex, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.9500 Å ) | ||||||||||||
Citation : |
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Hirose, M.,Okaniwa, M.,Miyazaki, T.
et al.
PubMed: 22883026 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | P15056 (BRAF_HUMAN) | ||||||||||||
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