ID 4FC0A STANDARD; PRT; 284 AA. DT CONVERTED FROM PDB (SEQRES) 4FC0 DE Serine/threonine-protein kinase B-raf OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.950 CC R-Factor 0.200 FT #SUB 6 447 ASP A 6 447 ASP B Protein S 3 FT #SUB 6 447 ASP A 64 505 ARG B Protein S 7 FT #SUB 8 449 TRP A 64 505 ARG B Protein S 2 FT #SUB 8 449 TRP A 65 506 LYS B Protein S 3 FT #SUB 8 449 TRP A 66 507 THR B Protein S 1 FT #SUB 8 449 TRP A 67 508 ARG B Protein S 11 FT #SUB 8 449 TRP A 124 565 TYR B Protein S 1 FT #SUB 33 474 LYS A 273 714 GLU B Protein S 2 FT #SUB 34 475 TRP A 124 565 TYR B Protein S 2 FT #SUB 35 476 HIS A 68 509 HIS B Protein A 6 FT #SUB 35 476 HIS A 120 561 GLN B Protein A 4 FT #SUB 35 476 HIS A 123 564 ASP B Protein S 10 FT #SUB 35 476 HIS A 124 565 TYR B Protein S 4 FT #SUB 35 476 HIS A 127 568 ALA B Protein S 2 FT #SUB 36 477 GLY A 120 561 GLN B Protein B 4 FT #SUB 63 504 LEU A 67 508 ARG B Protein B 1 FT #SUB 64 505 ARG A 6 447 ASP B Protein A 2 FT #SUB 64 505 ARG A 8 449 TRP B Protein B 2 FT #SUB 64 505 ARG A 67 508 ARG B Protein B 3 FT #SUB 65 506 LYS A 8 449 TRP B Protein B 3 FT #SUB 66 507 THR A 8 449 TRP B Protein B 2 FT #SUB 66 507 THR A 67 508 ARG B Protein B 4 FT #SUB 67 508 ARG A 8 449 TRP B Protein A 12 FT #SUB 67 508 ARG A 63 504 LEU B Protein S 1 FT #SUB 67 508 ARG A 64 505 ARG B Protein S 3 FT #SUB 67 508 ARG A 66 507 THR B Protein S 4 FT #SUB 67 508 ARG A 67 508 ARG B Protein S 4 FT #SUB 67 508 ARG A 73 514 LEU B Protein S 1 FT #SUB 67 508 ARG A 74 515 PHE B Protein S 12 FT #SUB 67 508 ARG A 75 516 MET B Protein B 3 FT #SUB 68 509 HIS A 35 476 HIS B Protein S 6 FT #SUB 68 509 HIS A 73 514 LEU B Protein B 2 FT #SUB 68 509 HIS A 75 516 MET B Protein S 1 FT #SUB 69 510 VAL A 73 514 LEU B Protein B 1 FT #SUB 69 510 VAL A 88 529 GLN B Protein S 1 FT #SUB 73 514 LEU A 67 508 ARG B Protein S 1 FT #SUB 73 514 LEU A 68 509 HIS B Protein S 2 FT #SUB 74 515 PHE A 67 508 ARG B Protein A 7 FT #SUB 75 516 MET A 67 508 ARG B Protein A 4 FT #SUB 75 516 MET A 68 509 HIS B Protein S 1 FT #SUB 88 529 GLN A 69 510 VAL B Protein S 1 FT #SUB 120 561 GLN A 35 476 HIS B Protein S 6 FT #SUB 120 561 GLN A 36 477 GLY B Protein S 5 FT #SUB 123 564 ASP A 35 476 HIS B Protein A 4 FT #SUB 124 565 TYR A 8 449 TRP B Protein S 1 FT #SUB 124 565 TYR A 34 475 TRP B Protein S 2 FT #SUB 124 565 TYR A 35 476 HIS B Protein A 4 FT #SUB 127 568 ALA A 35 476 HIS B Protein S 2 FT #SUB 128 569 LYS A 8 449 TRP B Protein S 2 FT #SUB 144 585 GLU A 146 587 LEU B Protein S 1 FT #SUB 146 587 LEU A 144 585 GLU B Protein S 5 FT #HET 21 462 ILE A 1 901 0T2 A S 1 FT #HET 39 480 ALA A 1 901 0T2 A S 3 FT #HET 41 482 LYS A 1 901 0T2 A S 7 FT #HET 59 500 GLU A 1 901 0T2 A S 15 FT #HET 62 503 VAL A 1 901 0T2 A S 2 FT #HET 63 504 LEU A 1 901 0T2 A S 3 FT #HET 72 513 LEU A 1 901 0T2 A S 4 FT #HET 85 526 ILE A 1 901 0T2 A A 4 FT #HET 87 528 THR A 1 901 0T2 A S 7 FT #HET 88 529 GLN A 1 901 0T2 A B 1 FT #HET 89 530 TRP A 1 901 0T2 A S 16 FT #HET 90 531 CYS A 1 901 0T2 A A 14 FT #HET 91 532 GLU A 1 901 0T2 A B 1 FT #HET 92 533 GLY A 1 901 0T2 A B 3 FT #HET 125 566 LEU A 1 901 0T2 A S 1 FT #HET 130 571 ILE A 1 901 0T2 A S 1 FT #HET 132 573 HIS A 1 901 0T2 A S 1 FT #HET 141 582 PHE A 1 901 0T2 A S 3 FT #HET 150 591 ILE A 1 901 0T2 A A 3 FT #HET 151 592 GLY A 1 901 0T2 A B 6 FT #HET 152 593 ASP A 1 901 0T2 A A 16 FT #HET 153 594 PHE A 1 901 0T2 A A 11 FT DISORDER 1 5 FT DISORDER 155 172 FT DISORDER 186 188 FT DISORDER 281 284 CC SEQUENCE 254 AA (ATOM); CC DDWEIPDGQI TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK CC TRHVNILLFM GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL CC HAKSIIHRDL KSNNIFLHED LTVKIGDFGG SILWMAPEVI RMNPYSFQSD VYAFGIVLYE CC LMTGQLPYSN INNRDQIIFM VGRGYLSPDL SKVRSNCPKA MKRLMAECLK KKRDERPLFP CC QILASIELLA RSLP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP CC ATOM -----DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP CC ********************************************* CC SEQRES QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH CC ATOM QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH CC ************************************************** CC SEQRES IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI CC ATOM IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI CC ************************************************** CC SEQRES GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF CC ATOM GDFG------------------GSILWMAPEVIRM---NPYSFQSDVYAF CC **** ************* ************ CC SEQRES GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL CC ATOM GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL CC ************************************************** CC SEQRES MAECLKKKRDERPLFPQILASIELLARSLPKIHR CC ATOM MAECLKKKRDERPLFPQILASIELLARSLP---- CC ****************************** SQ SEQUENCE 284 AA; MW; CN; GSDSSDDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV GVLRKTRHVN ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH IIETKFEMIK LIDIARQTAQ GMDYLHAKSI IHRDLKSNNI FLHEDLTVKI GDFGLATVKS RWSGSHQFEQ LSGSILWMAP EVIRMQDKNP YSFQSDVYAF GIVLYELMTG QLPYSNINNR DQIIFMVGRG YLSPDLSKVR SNCPKAMKRL MAECLKKKRD ERPLFPQILA SIELLARSLP KIHR // ID 4FC0B STANDARD; PRT; 284 AA. DT CONVERTED FROM PDB (SEQRES) 4FC0 DE Serine/threonine-protein kinase B-raf OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.950 CC R-Factor 0.200 FT #SUB 6 447 ASP B 6 447 ASP A Protein S 3 FT #SUB 6 447 ASP B 64 505 ARG A Protein S 2 FT #SUB 8 449 TRP B 64 505 ARG A Protein S 2 FT #SUB 8 449 TRP B 65 506 LYS A Protein S 3 FT #SUB 8 449 TRP B 66 507 THR A Protein S 2 FT #SUB 8 449 TRP B 67 508 ARG A Protein S 12 FT #SUB 8 449 TRP B 124 565 TYR A Protein S 1 FT #SUB 8 449 TRP B 128 569 LYS A Protein S 2 FT #SUB 34 475 TRP B 124 565 TYR A Protein S 2 FT #SUB 35 476 HIS B 68 509 HIS A Protein A 6 FT #SUB 35 476 HIS B 120 561 GLN A Protein B 6 FT #SUB 35 476 HIS B 123 564 ASP A Protein S 4 FT #SUB 35 476 HIS B 124 565 TYR A Protein S 4 FT #SUB 35 476 HIS B 127 568 ALA A Protein S 2 FT #SUB 36 477 GLY B 120 561 GLN A Protein B 5 FT #SUB 63 504 LEU B 67 508 ARG A Protein B 1 FT #SUB 64 505 ARG B 6 447 ASP A Protein A 7 FT #SUB 64 505 ARG B 8 449 TRP A Protein B 2 FT #SUB 64 505 ARG B 67 508 ARG A Protein B 3 FT #SUB 65 506 LYS B 8 449 TRP A Protein B 3 FT #SUB 66 507 THR B 8 449 TRP A Protein B 1 FT #SUB 66 507 THR B 67 508 ARG A Protein B 4 FT #SUB 67 508 ARG B 8 449 TRP A Protein S 11 FT #SUB 67 508 ARG B 63 504 LEU A Protein S 1 FT #SUB 67 508 ARG B 64 505 ARG A Protein S 3 FT #SUB 67 508 ARG B 66 507 THR A Protein S 4 FT #SUB 67 508 ARG B 67 508 ARG A Protein S 4 FT #SUB 67 508 ARG B 73 514 LEU A Protein S 1 FT #SUB 67 508 ARG B 74 515 PHE A Protein S 7 FT #SUB 67 508 ARG B 75 516 MET A Protein B 4 FT #SUB 68 509 HIS B 35 476 HIS A Protein S 6 FT #SUB 68 509 HIS B 73 514 LEU A Protein B 2 FT #SUB 68 509 HIS B 75 516 MET A Protein S 1 FT #SUB 69 510 VAL B 88 529 GLN A Protein S 1 FT #SUB 73 514 LEU B 67 508 ARG A Protein S 1 FT #SUB 73 514 LEU B 68 509 HIS A Protein S 2 FT #SUB 73 514 LEU B 69 510 VAL A Protein S 1 FT #SUB 74 515 PHE B 67 508 ARG A Protein A 12 FT #SUB 75 516 MET B 67 508 ARG A Protein S 3 FT #SUB 75 516 MET B 68 509 HIS A Protein S 1 FT #SUB 88 529 GLN B 69 510 VAL A Protein S 1 FT #SUB 120 561 GLN B 35 476 HIS A Protein A 4 FT #SUB 120 561 GLN B 36 477 GLY A Protein S 4 FT #SUB 123 564 ASP B 35 476 HIS A Protein A 10 FT #SUB 124 565 TYR B 8 449 TRP A Protein S 1 FT #SUB 124 565 TYR B 34 475 TRP A Protein S 2 FT #SUB 124 565 TYR B 35 476 HIS A Protein A 4 FT #SUB 127 568 ALA B 35 476 HIS A Protein S 2 FT #SUB 144 585 GLU B 146 587 LEU A Protein S 5 FT #SUB 146 587 LEU B 144 585 GLU A Protein S 1 FT #SUB 273 714 GLU B 33 474 LYS A Protein S 2 FT #HET 29 470 VAL B 2 901 0T2 B S 1 FT #HET 39 480 ALA B 2 901 0T2 B S 5 FT #HET 41 482 LYS B 2 901 0T2 B S 6 FT #HET 59 500 GLU B 2 901 0T2 B S 12 FT #HET 62 503 VAL B 2 901 0T2 B S 2 FT #HET 63 504 LEU B 2 901 0T2 B S 3 FT #HET 72 513 LEU B 2 901 0T2 B S 2 FT #HET 85 526 ILE B 2 901 0T2 B A 3 FT #HET 87 528 THR B 2 901 0T2 B S 7 FT #HET 88 529 GLN B 2 901 0T2 B B 1 FT #HET 89 530 TRP B 2 901 0T2 B S 21 FT #HET 90 531 CYS B 2 901 0T2 B A 12 FT #HET 92 533 GLY B 2 901 0T2 B B 4 FT #HET 125 566 LEU B 2 901 0T2 B S 1 FT #HET 132 573 HIS B 2 901 0T2 B S 4 FT #HET 141 582 PHE B 2 901 0T2 B S 5 FT #HET 150 591 ILE B 2 901 0T2 B B 2 FT #HET 151 592 GLY B 2 901 0T2 B B 7 FT #HET 152 593 ASP B 2 901 0T2 B A 14 FT #HET 153 594 PHE B 2 901 0T2 B A 10 FT #HET 156 597 ALA B 2 901 0T2 B S 2 FT DISORDER 1 5 FT DISORDER 163 172 FT DISORDER 279 284 CC SEQUENCE 263 AA (ATOM); CC DDWEIPDGQI TVGQRIGSGS FGTVYKGKWH GDVAVKMLNV TAPTPQQLQA FKNEVGVLRK CC TRHVNILLFM GYSTKPQLAI VTQWCEGSSL YHHLHIIETK FEMIKLIDIA RQTAQGMDYL CC HAKSIIHRDL KSNNIFLHED LTVKIGDFGL ATVKSRWGSI LWMAPEVIRM QDKNPYSFQS CC DVYAFGIVLY ELMTGQLPYS NINNRDQIIF MVGRGYLSPD LSKVRSNCPK AMKRLMAECL CC KKKRDERPLF PQILASIELL ARS CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP CC ATOM -----DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP CC ********************************************* CC SEQRES QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH CC ATOM QQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH CC ************************************************** CC SEQRES IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI CC ATOM IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI CC ************************************************** CC SEQRES GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAF CC ATOM GDFGLATVKSRW----------GSILWMAPEVIRMQDKNPYSFQSDVYAF CC ************ **************************** CC SEQRES GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL CC ATOM GIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRL CC ************************************************** CC SEQRES MAECLKKKRDERPLFPQILASIELLARSLPKIHR CC ATOM MAECLKKKRDERPLFPQILASIELLARS------ CC **************************** SQ SEQUENCE 284 AA; MW; CN; GSDSSDDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV GVLRKTRHVN ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH IIETKFEMIK LIDIARQTAQ GMDYLHAKSI IHRDLKSNNI FLHEDLTVKI GDFGLATVKS RWSGSHQFEQ LSGSILWMAP EVIRMQDKNP YSFQSDVYAF GIVLYELMTG QLPYSNINNR DQIIFMVGRG YLSPDLSKVR SNCPKAMKRL MAECLKKKRD ERPLFPQILA SIELLARSLP KIHR //