Brand  (β version)

PDB ID: 4E4M

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Ligands
Code Name Style Show Link
0NH 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Modification
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Structure summary

Code : 4E4M   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : JAK2 kinase (JH1 domain) in complex with compound 30
Release Data : 2012-05-30
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK2 A,B,D,E Janus kinase 2, JAK-2
ec: 2.7.10.2
fragment: protein kinase domain JH1, UNP residues 833-1132
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK2
expression_system_common: Fall armyworm
Authors : Eigenbrot, C.
Keywords : o-phosphotyrosine, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.

Kulagowski, J.J.,Blair, W.,Bull, R.J.  et al.
(2012)  J.Med.Chem.  55 : 5901 - 5921

PubMed: 22591402
DOI: 10.1021/jm300438j

Reaction

Chain : A, B, D, E
UniProt : O60674 (JAK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:7615558, PubMed:9618263
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