PDB ID: 4DDL
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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ZN | Zinc ion | PoSSuM | |||
SO4 | Sulfate ion | PoSSuM | |||
0JQ | 2-{1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]piperidin-4-yl}propan-2-ol | PoSSuM |
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Download interaction data: 4DDL
Structure summary
Code : | 4DDL PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Hydrolase/Hydrolase Inhibitor | ||||||||||||
Title : | PDE10a Crystal Structure Complexed with Novel Inhibitor | ||||||||||||
Release Data : | 2012-03-21 | ||||||||||||
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Authors : | Chmait, S., Jordan, S., Zhang, J. | ||||||||||||
Keywords : | Phosphodiesterase 10a, Hydrolase, Hydrolase-Hydrolase Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.07 Å ) | ||||||||||||
Citation : |
Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.
Hu, E.,Kunz, R.K.,Rumfelt, S.
et al.
PubMed: 22365755 |
Reaction
Chain : | A, B | ||||||||||||||||
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UniProt : | Q9Y233 (PDE10_HUMAN) | ||||||||||||||||
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