ID 4DDLA STANDARD; PRT; 338 AA. DT CONVERTED FROM PDB (SEQRES) 4DDL DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.070 CC R-Factor 0.186 FT #SUB 94 535 HIS A 201 642 GLY B Protein S 5 FT #SUB 94 535 HIS A 204 645 ASN B Protein B 1 FT #SUB 95 536 THR A 203 644 LEU B Protein A 5 FT #SUB 95 536 THR A 204 645 ASN B Protein B 4 FT #SUB 95 536 THR A 205 646 LEU B Protein A 6 FT #SUB 96 537 LEU A 96 537 LEU B Protein S 1 FT #SUB 96 537 LEU A 206 647 ASN B Protein B 3 FT #SUB 97 538 PHE A 204 645 ASN B Protein B 4 FT #SUB 97 538 PHE A 206 647 ASN B Protein B 4 FT #SUB 98 539 THR A 206 647 ASN B Protein A 6 FT #SUB 102 543 ARG A 204 645 ASN B Protein S 2 FT #SUB 201 642 GLY A 94 535 HIS B Protein B 2 FT #SUB 201 642 GLY A 102 543 ARG B Protein B 1 FT #SUB 203 644 LEU A 95 536 THR B Protein A 5 FT #SUB 203 644 LEU A 102 543 ARG B Protein B 1 FT #SUB 204 645 ASN A 95 536 THR B Protein A 3 FT #SUB 204 645 ASN A 97 538 PHE B Protein S 3 FT #SUB 204 645 ASN A 99 540 ASP B Protein S 2 FT #SUB 204 645 ASN A 102 543 ARG B Protein A 6 FT #SUB 205 646 LEU A 95 536 THR B Protein A 5 FT #SUB 206 647 ASN A 96 537 LEU B Protein S 4 FT #SUB 206 647 ASN A 97 538 PHE B Protein S 4 FT #SUB 206 647 ASN A 98 539 THR B Protein S 5 FT #SUB 206 647 ASN A 211 652 ARG B Protein S 3 FT #HET 31 472 PHE A 3 1003 SO4 A A 7 FT #HET 32 473 GLU A 3 1003 SO4 A B 3 FT #HET 33 474 ASN A 3 1003 SO4 A A 12 FT #HET 34 475 MET A 3 1003 SO4 A B 1 FT #HET 56 497 LYS A 4 1004 SO4 A S 6 FT #HET 69 510 ARG A 7 1007 SO4 A A 9 FT #HET 70 511 ARG A 7 1007 SO4 A A 16 FT #HET 71 512 VAL A 5 1005 SO4 A S 3 FT #HET 72 513 PRO A 5 1005 SO4 A S 5 FT #HET 78 519 HIS A 1 1001 ZN A S 3 FT #HET 96 537 LEU A 6 1006 SO4 A B 3 FT #HET 112 553 HIS A 1 1001 ZN A S 3 FT #HET 113 554 ASP A 1 1001 ZN A S 3 FT #HET 113 554 ASP A 2 1002 ZN A S 3 FT #HET 117 558 ARG A 5 1005 SO4 A B 4 FT #HET 118 559 GLY A 5 1005 SO4 A B 7 FT #HET 119 560 PHE A 5 1005 SO4 A S 2 FT #HET 122 563 SER A 10 1010 0JQ A S 2 FT #HET 154 595 LEU A 4 1004 SO4 A B 1 FT #HET 156 597 GLY A 4 1004 SO4 A B 7 FT #HET 157 598 HIS A 4 1004 SO4 A B 3 FT #HET 158 599 ASN A 4 1004 SO4 A A 5 FT #HET 161 602 SER A 4 1004 SO4 A S 1 FT #HET 176 617 ARG A 9 1009 SO4 A S 6 FT #HET 177 618 LYS A 9 1009 SO4 A S 3 FT #HET 184 625 LEU A 10 1010 0JQ A S 2 FT #HET 204 645 ASN A 18 808 SO4 B S 3 FT #HET 205 646 LEU A 6 1006 SO4 A A 3 FT #HET 206 647 ASN A 6 1006 SO4 A A 7 FT #HET 206 647 ASN A 18 808 SO4 B A 4 FT #HET 207 648 ASN A 18 808 SO4 B B 1 FT #HET 211 652 ARG A 6 1006 SO4 A S 4 FT #HET 223 664 ASP A 1 1001 ZN A S 3 FT #HET 224 665 LEU A 10 1010 0JQ A S 2 FT #HET 227 668 VAL A 10 1010 0JQ A S 1 FT #HET 231 672 TRP A 8 1008 SO4 A S 2 FT #HET 232 673 PRO A 8 1008 SO4 A A 3 FT #HET 235 676 LYS A 8 1008 SO4 A S 2 FT #HET 241 682 ILE A 10 1010 0JQ A S 2 FT #HET 242 683 TYR A 10 1010 0JQ A S 1 FT #HET 244 685 GLU A 5 1005 SO4 A A 8 FT #HET 245 686 PHE A 10 1010 0JQ A S 6 FT #HET 247 688 ALA A 5 1005 SO4 A S 2 FT #HET 260 701 ILE A 10 1010 0JQ A S 1 FT #HET 262 703 MET A 10 1010 0JQ A S 1 FT #HET 275 716 GLN A 10 1010 0JQ A S 6 FT #HET 278 719 PHE A 10 1010 0JQ A S 27 FT DISORDER 319 338 CC SEQUENCE 318 AA (ATOM); CC TSEEWQGLMQ FTLPVRLCKE IELFHFDIGP FENMWPGIFV YMVHRSCGTS CFELEKLCRF CC IMSVKKNYRR VPYHNWKHAV TVAHCMYAIL QNNHTLFTDL ERKGLLIACL CHDLDHRGFS CC NSYLQKFDHP LAALYSTSTM EQHHFSQTVS ILQLEGHNIF STLSSSEYEQ VLEIIRKAII CC ATDLALYFGN RKQLEEMYQT GSLNLNNQSH RDRVIGLMMT ACDLCSVTKL WPVTKLTAND CC IYAEFWAEGD EMKKLGIQPI PMMDRDKKDE VPQGQLGFYN AVAIPCYTTL TQILPPTEPL CC LKACRDNLSQ WEKVIRGE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES TSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS CC ATOM TSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS CC ************************************************** CC SEQRES CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL CC ATOM CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL CC ************************************************** CC SEQRES ERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS CC ATOM ERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS CC ************************************************** CC SEQRES ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT CC ATOM ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT CC ************************************************** CC SEQRES GSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD CC ATOM GSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD CC ************************************************** CC SEQRES EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPL CC ATOM EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPL CC ************************************************** CC SEQRES LKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED CC ATOM LKACRDNLSQWEKVIRGE-------------------- CC ****************** SQ SEQUENCE 338 AA; MW; CN; TSEEWQGLMQ FTLPVRLCKE IELFHFDIGP FENMWPGIFV YMVHRSCGTS CFELEKLCRF IMSVKKNYRR VPYHNWKHAV TVAHCMYAIL QNNHTLFTDL ERKGLLIACL CHDLDHRGFS NSYLQKFDHP LAALYSTSTM EQHHFSQTVS ILQLEGHNIF STLSSSEYEQ VLEIIRKAII ATDLALYFGN RKQLEEMYQT GSLNLNNQSH RDRVIGLMMT ACDLCSVTKL WPVTKLTAND IYAEFWAEGD EMKKLGIQPI PMMDRDKKDE VPQGQLGFYN AVAIPCYTTL TQILPPTEPL LKACRDNLSQ WEKVIRGEET ATWISSPSVA QKAAASED // ID 4DDLB STANDARD; PRT; 338 AA. DT CONVERTED FROM PDB (SEQRES) 4DDL DE cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.070 CC R-Factor 0.186 FT #SUB 94 535 HIS B 201 642 GLY A Protein S 2 FT #SUB 95 536 THR B 203 644 LEU A Protein A 5 FT #SUB 95 536 THR B 204 645 ASN A Protein B 3 FT #SUB 95 536 THR B 205 646 LEU A Protein A 5 FT #SUB 96 537 LEU B 96 537 LEU A Protein S 1 FT #SUB 96 537 LEU B 206 647 ASN A Protein B 4 FT #SUB 97 538 PHE B 204 645 ASN A Protein B 3 FT #SUB 97 538 PHE B 206 647 ASN A Protein B 4 FT #SUB 98 539 THR B 206 647 ASN A Protein A 5 FT #SUB 99 540 ASP B 204 645 ASN A Protein A 2 FT #SUB 102 543 ARG B 201 642 GLY A Protein S 1 FT #SUB 102 543 ARG B 203 644 LEU A Protein S 1 FT #SUB 102 543 ARG B 204 645 ASN A Protein S 6 FT #SUB 201 642 GLY B 94 535 HIS A Protein B 5 FT #SUB 203 644 LEU B 95 536 THR A Protein A 5 FT #SUB 204 645 ASN B 94 535 HIS A Protein S 1 FT #SUB 204 645 ASN B 95 536 THR A Protein A 4 FT #SUB 204 645 ASN B 97 538 PHE A Protein S 4 FT #SUB 204 645 ASN B 102 543 ARG A Protein S 2 FT #SUB 205 646 LEU B 95 536 THR A Protein A 6 FT #SUB 206 647 ASN B 96 537 LEU A Protein S 3 FT #SUB 206 647 ASN B 97 538 PHE A Protein S 4 FT #SUB 206 647 ASN B 98 539 THR A Protein S 6 FT #SUB 211 652 ARG B 206 647 ASN A Protein S 3 FT #HET 56 497 LYS B 17 807 SO4 B S 6 FT #HET 67 508 ASN B 19 809 SO4 B S 5 FT #HET 68 509 TYR B 14 804 SO4 B B 1 FT #HET 69 510 ARG B 13 803 SO4 B S 8 FT #HET 69 510 ARG B 14 804 SO4 B A 8 FT #HET 70 511 ARG B 14 804 SO4 B A 10 FT #HET 71 512 VAL B 20 810 SO4 B S 2 FT #HET 72 513 PRO B 20 810 SO4 B S 4 FT #HET 78 519 HIS B 11 801 ZN B S 3 FT #HET 96 537 LEU B 6 1006 SO4 A A 2 FT #HET 98 539 THR B 18 808 SO4 B A 5 FT #HET 99 540 ASP B 18 808 SO4 B A 10 FT #HET 112 553 HIS B 11 801 ZN B S 3 FT #HET 113 554 ASP B 11 801 ZN B S 3 FT #HET 113 554 ASP B 12 802 ZN B S 3 FT #HET 117 558 ARG B 13 803 SO4 B S 11 FT #HET 117 558 ARG B 20 810 SO4 B B 5 FT #HET 118 559 GLY B 20 810 SO4 B B 6 FT #HET 119 560 PHE B 20 810 SO4 B S 2 FT #HET 122 563 SER B 21 811 0JQ B S 3 FT #HET 129 570 HIS B 13 803 SO4 B S 2 FT #HET 147 588 GLN B 19 809 SO4 B S 1 FT #HET 150 591 SER B 19 809 SO4 B S 4 FT #HET 151 592 ILE B 19 809 SO4 B S 3 FT #HET 154 595 LEU B 19 809 SO4 B S 1 FT #HET 155 596 GLU B 17 807 SO4 B S 1 FT #HET 156 597 GLY B 17 807 SO4 B B 6 FT #HET 157 598 HIS B 17 807 SO4 B B 2 FT #HET 158 599 ASN B 17 807 SO4 B A 4 FT #HET 184 625 LEU B 21 811 0JQ B S 2 FT #HET 205 646 LEU B 6 1006 SO4 A A 3 FT #HET 211 652 ARG B 6 1006 SO4 A S 2 FT #HET 223 664 ASP B 11 801 ZN B S 3 FT #HET 224 665 LEU B 21 811 0JQ B S 2 FT #HET 227 668 VAL B 21 811 0JQ B S 1 FT #HET 232 673 PRO B 16 806 SO4 B A 6 FT #HET 235 676 LYS B 16 806 SO4 B S 3 FT #HET 236 677 LEU B 16 806 SO4 B S 2 FT #HET 241 682 ILE B 21 811 0JQ B S 1 FT #HET 242 683 TYR B 21 811 0JQ B S 2 FT #HET 244 685 GLU B 20 810 SO4 B A 7 FT #HET 245 686 PHE B 21 811 0JQ B S 7 FT #HET 247 688 ALA B 20 810 SO4 B S 2 FT #HET 253 694 LYS B 15 805 SO4 B A 4 FT #HET 256 697 GLY B 15 805 SO4 B B 4 FT #HET 257 698 ILE B 15 805 SO4 B B 5 FT #HET 258 699 GLN B 15 805 SO4 B A 4 FT #HET 260 701 ILE B 21 811 0JQ B S 1 FT #HET 262 703 MET B 21 811 0JQ B S 3 FT #HET 275 716 GLN B 21 811 0JQ B S 10 FT #HET 278 719 PHE B 21 811 0JQ B S 27 FT DISORDER 1 10 FT DISORDER 319 338 CC SEQUENCE 308 AA (ATOM); CC FTLPVRLCKE IELFHFDIGP FENMWPGIFV YMVHRSCGTS CFELEKLCRF IMSVKKNYRR CC VPYHNWKHAV TVAHCMYAIL QNNHTLFTDL ERKGLLIACL CHDLDHRGFS NSYLQKFDHP CC LAALYSTSTM EQHHFSQTVS ILQLEGHNIF STLSSSEYEQ VLEIIRKAII ATDLALYFGN CC RKQLEEMYQT GSLNLNNQSH RDRVIGLMMT ACDLCSVTKL WPVTKLTAND IYAEFWAEGD CC EMKKLGIQPI PMMDRDKKDE VPQGQLGFYN AVAIPCYTTL TQILPPTEPL LKACRDNLSQ CC WEKVIRGE CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES TSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS CC ATOM ----------FTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTS CC **************************************** CC SEQRES CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL CC ATOM CFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDL CC ************************************************** CC SEQRES ERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS CC ATOM ERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVS CC ************************************************** CC SEQRES ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT CC ATOM ILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQT CC ************************************************** CC SEQRES GSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD CC ATOM GSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD CC ************************************************** CC SEQRES EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPL CC ATOM EMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPL CC ************************************************** CC SEQRES LKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED CC ATOM LKACRDNLSQWEKVIRGE-------------------- CC ****************** SQ SEQUENCE 338 AA; MW; CN; TSEEWQGLMQ FTLPVRLCKE IELFHFDIGP FENMWPGIFV YMVHRSCGTS CFELEKLCRF IMSVKKNYRR VPYHNWKHAV TVAHCMYAIL QNNHTLFTDL ERKGLLIACL CHDLDHRGFS NSYLQKFDHP LAALYSTSTM EQHHFSQTVS ILQLEGHNIF STLSSSEYEQ VLEIIRKAII ATDLALYFGN RKQLEEMYQT GSLNLNNQSH RDRVIGLMMT ACDLCSVTKL WPVTKLTAND IYAEFWAEGD EMKKLGIQPI PMMDRDKKDE VPQGQLGFYN AVAIPCYTTL TQILPPTEPL LKACRDNLSQ WEKVIRGEET ATWISSPSVA QKAAASED //