Het-PDB Navi2 (PDB: 4CRL)

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Ligands
Code	Name		Style	Show	Link
C1I	Cortistatin a				PoSSuM
FMT	Formic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 4CRL

Code :

4CRL PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of human CDK8-Cyclin C in complex with cortistatin A

Release Data :

2015-09-23

Compound :

mol_id	molecule	chains	synonym
1	CYCLIN-DEPENDENT KINASE 8	A	CELL DIVISION PROTEIN KINASE 8, MEDIATOR COMPLEX SUBUNIT CDK8, MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT CDK8, PROTEIN KINASE K35, CDK8
	ec: 2.7.11.22 fragment: KINASE DOMAIN, RESIDUES 1-403

mol_id	molecule	chains	synonym
2	CYCLIN-C	B	SRB11 HOMOLOG, HSRB11, CYCLINC

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_common: FALL ARMYWORM expression_system_vector_type: BACULOVIRUS

mol_id	organism_scientific	organism_common	expression_system
2	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_common: FALL ARMYWORM expression_system_vector_type: BACULOVIRUS

Authors :

Myers, A.G., Shair, M.D.

Keywords :

TRANSFERASE, CYCLIN-DEPENDENT KINASE 8, CDK8, CYCLIN C, CCNC, CORTISTATIN A, MEDIATOR KINASE, MEDIATOR COMPLEX, SUPER-ENHANCER, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml

Pelish, H.E.,Liau, B.B.,Nitulescu, I.I. et al.
(2015) Nature 526 : 273

PDB ID: 4CRL