Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
C1I Cortistatin a
FMT Formic acid
Code : 4CRL
Header : TRANSFERASE
Title : Crystal structure of human CDK8-Cyclin C in complex with cortistatin A
Release Data : 2015-09-23
Compound :
mol_id molecule chains synonym
1 CYCLIN-DEPENDENT KINASE 8 A CELL DIVISION PROTEIN KINASE 8, MEDIATOR COMPLEX SUBUNIT CDK8, MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT CDK8, PROTEIN KINASE K35, CDK8
ec: 2.7.11.22
fragment: KINASE DOMAIN, RESIDUES 1-403
mol_id molecule chains synonym
2 CYCLIN-C B SRB11 HOMOLOG, HSRB11, CYCLINC
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_vector_type: BACULOVIRUS
mol_id organism_scientific organism_common expression_system
2 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_common: FALL ARMYWORM
expression_system_vector_type: BACULOVIRUS
Authors : Myers, A.G., Shair, M.D.
Keywords : TRANSFERASE, CYCLIN-DEPENDENT KINASE 8, CDK8, CYCLIN C, CCNC, CORTISTATIN A, MEDIATOR KINASE, MEDIATOR COMPLEX, SUPER-ENHANCER, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml

Pelish, H.E.,Liau, B.B.,Nitulescu, I.I.  et al.
(2015)  Nature  526 : 273

PubMed: 26416749
DOI: 10.1038/NATURE14904

Chain : A
UniProt : P49336 (CDK8_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Chain : B
UniProt : P24863 (CCNC_HUMAN)
Reaction : -