ID	4CRLA	STANDARD;	PRT;	406	AA.
DT	CONVERTED FROM PDB (SEQRES) 4CRL
DE	CYCLIN-DEPENDENT KINASE 8
OS	HOMO SAPIENS
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.400
CC	R-Factor	0.201
FT	#SUB	1	  -2 	ASP	A	136	 134 	HIS	B	Protein	S	3
FT	#SUB	1	  -2 	ASP	A	139	 137 	GLU	B	Protein	A	5
FT	#SUB	3	   0 	LYS	A	132	 130 	TYR	B	Protein	S	1
FT	#SUB	3	   0 	LYS	A	262	 260 	PRO	B	Protein	A	6
FT	#SUB	4	   1 	MET	A	82	  80 	SER	B	Protein	A	3
FT	#SUB	4	   1 	MET	A	143	 141 	TYR	B	Protein	S	3
FT	#SUB	4	   1 	MET	A	262	 260 	PRO	B	Protein	B	1
FT	#SUB	4	   1 	MET	A	263	 261 	LYS	B	Protein	B	1
FT	#SUB	5	   2 	ASP	A	81	  79 	LYS	B	Protein	S	4
FT	#SUB	5	   2 	ASP	A	82	  80 	SER	B	Protein	A	3
FT	#SUB	5	   2 	ASP	A	262	 260 	PRO	B	Protein	B	1
FT	#SUB	5	   2 	ASP	A	263	 261 	LYS	B	Protein	A	7
FT	#SUB	6	   3 	TYR	A	263	 261 	LYS	B	Protein	A	2
FT	#SUB	6	   3 	TYR	A	264	 262 	PRO	B	Protein	S	1
FT	#SUB	6	   3 	TYR	A	265	 263 	PRO	B	Protein	S	1
FT	#SUB	6	   3 	TYR	A	266	 264 	PRO	B	Protein	S	2
FT	#SUB	7	   4 	ASP	A	263	 261 	LYS	B	Protein	S	3
FT	#SUB	8	   5 	PHE	A	74	  72 	PHE	B	Protein	S	1
FT	#SUB	8	   5 	PHE	A	78	  76 	TYR	B	Protein	S	7
FT	#SUB	8	   5 	PHE	A	82	  80 	SER	B	Protein	S	4
FT	#SUB	8	   5 	PHE	A	83	  81 	ILE	B	Protein	S	1
FT	#SUB	8	   5 	PHE	A	143	 141 	TYR	B	Protein	S	1
FT	#SUB	9	   6 	LYS	A	143	 141 	TYR	B	Protein	S	3
FT	#SUB	12	   9 	LEU	A	78	  76 	TYR	B	Protein	S	1
FT	#SUB	12	   9 	LEU	A	143	 141 	TYR	B	Protein	S	2
FT	#SUB	16	  13 	ARG	A	146	 144 	GLU	B	Protein	S	7
FT	#SUB	62	  59 	ILE	A	98	  96 	LYS	B	Protein	A	5
FT	#SUB	62	  59 	ILE	A	141	 139 	GLU	B	Protein	S	4
FT	#SUB	62	  59 	ILE	A	142	 140 	PHE	B	Protein	S	2
FT	#SUB	62	  59 	ILE	A	145	 143 	LEU	B	Protein	S	1
FT	#SUB	64	  61 	MET	A	98	  96 	LYS	B	Protein	S	3
FT	#SUB	64	  61 	MET	A	101	  99 	GLU	B	Protein	S	3
FT	#SUB	64	  61 	MET	A	104	 102 	VAL	B	Protein	S	1
FT	#SUB	67	  64 	CYS	A	98	  96 	LYS	B	Protein	S	3
FT	#SUB	67	  64 	CYS	A	99	  97 	VAL	B	Protein	S	3
FT	#SUB	67	  64 	CYS	A	152	 150 	LEU	B	Protein	B	1
FT	#SUB	68	  65 	ARG	A	98	  96 	LYS	B	Protein	S	1
FT	#SUB	68	  65 	ARG	A	99	  97 	VAL	B	Protein	S	2
FT	#SUB	68	  65 	ARG	A	101	  99 	GLU	B	Protein	S	4
FT	#SUB	70	  67 	ILE	A	150	 148 	CYS	B	Protein	S	2
FT	#SUB	71	  68 	ALA	A	152	 150 	LEU	B	Protein	S	1
FT	#SUB	71	  68 	ALA	A	153	 151 	ILE	B	Protein	B	1
FT	#SUB	72	  69 	LEU	A	2	   0 	ALA	B	Protein	S	1
FT	#SUB	74	  71 	ARG	A	11	   9 	SER	B	Protein	S	1
FT	#SUB	74	  71 	ARG	A	15	  13 	GLN	B	Protein	S	5
FT	#SUB	74	  71 	ARG	A	149	 147 	ASP	B	Protein	S	5
FT	#SUB	74	  71 	ARG	A	150	 148 	CYS	B	Protein	S	3
FT	#SUB	74	  71 	ARG	A	151	 149 	CYS	B	Protein	S	3
FT	#SUB	75	  72 	GLU	A	10	   8 	SER	B	Protein	S	3
FT	#SUB	75	  72 	GLU	A	11	   9 	SER	B	Protein	S	10
FT	#SUB	75	  72 	GLU	A	153	 151 	ILE	B	Protein	S	2
FT	#SUB	76	  73 	LEU	A	3	   1 	MET	B	Protein	S	2
FT	#SUB	87	  84 	VAL	A	150	 148 	CYS	B	Protein	S	3
FT	#SUB	89	  86 	LEU	A	142	 140 	PHE	B	Protein	S	1
FT	#SUB	89	  86 	LEU	A	146	 144 	GLU	B	Protein	S	1
FT	#SUB	90	  87 	SER	A	142	 140 	PHE	B	Protein	B	2
FT	#SUB	91	  88 	HIS	A	142	 140 	PHE	B	Protein	S	3
FT	#SUB	94	  91 	ARG	A	138	 136 	LEU	B	Protein	S	9
FT	#SUB	94	  91 	ARG	A	142	 140 	PHE	B	Protein	A	5
FT	#SUB	148	 145 	ASN	A	2	   0 	ALA	B	Protein	B	2
FT	#SUB	148	 145 	ASN	A	3	   1 	MET	B	Protein	A	8
FT	#SUB	148	 145 	ASN	A	6	   4 	ASN	B	Protein	S	2
FT	#SUB	149	 146 	TRP	A	1	  -1 	LYS	B	Protein	S	2
FT	#SUB	150	 147 	VAL	A	3	   1 	MET	B	Protein	S	1
FT	#SUB	181	 178 	ARG	A	101	  99 	GLU	B	Protein	B	2
FT	#SUB	182	 179 	LEU	A	101	  99 	GLU	B	Protein	B	1
FT	#SUB	183	 180 	PHE	A	101	  99 	GLU	B	Protein	B	1
FT	#HET	30	  27 	VAL	A	1	1360 	C1I	A	B	2
FT	#HET	35	  32 	TYR	A	1	1360 	C1I	A	S	5
FT	#HET	38	  35 	VAL	A	1	1360 	C1I	A	S	3
FT	#HET	53	  50 	ALA	A	1	1360 	C1I	A	S	3
FT	#HET	55	  52 	LYS	A	4	1363 	FMT	A	S	3
FT	#HET	69	  66 	GLU	A	4	1363 	FMT	A	S	2
FT	#HET	82	  79 	ILE	A	1	1360 	C1I	A	S	2
FT	#HET	82	  79 	ILE	A	4	1363 	FMT	A	S	1
FT	#HET	100	  97 	PHE	A	4	1363 	FMT	A	S	3
FT	#HET	101	  98 	ASP	A	1	1360 	C1I	A	B	1
FT	#HET	102	  99 	TYR	A	1	1360 	C1I	A	B	2
FT	#HET	103	 100 	ALA	A	1	1360 	C1I	A	A	7
FT	#HET	104	 101 	GLU	A	3	1362 	FMT	A	S	5
FT	#HET	105	 102 	HIS	A	3	1362 	FMT	A	S	4
FT	#HET	106	 103 	ASP	A	1	1360 	C1I	A	S	1
FT	#HET	108	 105 	TRP	A	1	1360 	C1I	A	S	11
FT	#HET	109	 106 	HIS	A	1	1360 	C1I	A	S	2
FT	#HET	127	 124 	PRO	A	2	1361 	FMT	A	S	1
FT	#HET	128	 125 	ARG	A	2	1361 	FMT	A	B	1
FT	#HET	129	 126 	GLY	A	2	1361 	FMT	A	B	7
FT	#HET	130	 127 	MET	A	2	1361 	FMT	A	B	1
FT	#HET	158	 155 	ALA	A	1	1360 	C1I	A	A	5
FT	#HET	161	 158 	LEU	A	1	1360 	C1I	A	S	4
FT	#HET	164	 161 	GLY	A	3	1362 	FMT	A	B	3
FT	#HET	165	 162 	GLU	A	3	1362 	FMT	A	A	6
FT	#HET	176	 173 	ASP	A	4	1363 	FMT	A	B	4
FT	#HET	354	 351 	ILE	A	3	1362 	FMT	A	S	2
FT	#HET	359	 356 	ARG	A	1	1360 	C1I	A	S	3
FT	DISORDER	118	123
FT	DISORDER	188	197
FT	DISORDER	242	248
FT	DISORDER	363	406
CC	SEQUENCE	339 AA (ATOM);
CC	DDKMDYDFKV KLSSERERVE DLFEYEGCKV GRGTYGHVYK AKRKDGKDDK DYALKQIEGT
CC	GISMSACREI ALLRELKHPN VISLQKVFLS HADRKVWLLF DYAEHDLWHI IKFHRASVQL
CC	PRGMVKSLLY QILDGIHYLH ANWVLHRDLK PANILVMGEG PERGRVKIAD MGFARLFNSP
CC	LVTFWYRAPE LLLGARHYTK AIDIWAIGCI FAELLTSEPI FHCRQPYHHD QLDRIFNVMG
CC	FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH KVKPDSKAFH LLQKLLTMDP
CC	IKRITSEQAM QDPYFLEDPL PTSDVFAGCQ IPYPKREFL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES DDKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDK
CC	ATOM   DDKMDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDK
CC	       **************************************************
CC	SEQRES DYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLF
CC	ATOM   DYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLF
CC	       **************************************************
CC	SEQRES DYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWV
CC	ATOM   DYAEHDLWHIIKFHRAS------VQLPRGMVKSLLYQILDGIHYLHANWV
CC	       *****************      ***************************
CC	SEQRES LHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTF
CC	ATOM   LHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPL----------VTF
CC	       *************************************          ***
CC	SEQRES WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPY
CC	ATOM   WYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQ-------PY
CC	       *****************************************       **
CC	SEQRES HHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM
CC	ATOM   HHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYM
CC	       **************************************************
CC	SEQRES EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFA
CC	ATOM   EKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFA
CC	       **************************************************
CC	SEQRES GCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQ
CC	ATOM   GCQIPYPKREFL--------------------------------------
CC	       ************                                      
CC	SEQRES GPPLKK
CC	ATOM   ------
CC	             
SQ	SEQUENCE	406 AA;      MW;         CN;
	DDKMDYDFKV KLSSERERVE DLFEYEGCKV GRGTYGHVYK AKRKDGKDDK DYALKQIEGT
	GISMSACREI ALLRELKHPN VISLQKVFLS HADRKVWLLF DYAEHDLWHI IKFHRASKAN
	KKPVQLPRGM VKSLLYQILD GIHYLHANWV LHRDLKPANI LVMGEGPERG RVKIADMGFA
	RLFNSPLKPL ADLDPVVVTF WYRAPELLLG ARHYTKAIDI WAIGCIFAEL LTSEPIFHCR
	QEDIKTSNPY HHDQLDRIFN VMGFPADKDW EDIKKMPEHS TLMKDFRRNT YTNCSLIKYM
	EKHKVKPDSK AFHLLQKLLT MDPIKRITSE QAMQDPYFLE DPLPTSDVFA GCQIPYPKRE
	FLTEEEPDDK GDKKNQQQQQ GNNHTNGTGH PGNQDSSHTQ GPPLKK
//
ID	4CRLB	STANDARD;	PRT;	285	AA.
DT	CONVERTED FROM PDB (SEQRES) 4CRL
DE	CYCLIN-C
OS	HOMO SAPIENS
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.400
CC	R-Factor	0.201
FT	#SUB	1	  -1 	LYS	B	149	 146 	TRP	A	Protein	B	2
FT	#SUB	2	   0 	ALA	B	72	  69 	LEU	A	Protein	S	1
FT	#SUB	2	   0 	ALA	B	148	 145 	ASN	A	Protein	B	2
FT	#SUB	3	   1 	MET	B	76	  73 	LEU	A	Protein	S	2
FT	#SUB	3	   1 	MET	B	148	 145 	ASN	A	Protein	A	8
FT	#SUB	3	   1 	MET	B	150	 147 	VAL	A	Protein	S	1
FT	#SUB	6	   4 	ASN	B	148	 145 	ASN	A	Protein	S	2
FT	#SUB	10	   8 	SER	B	75	  72 	GLU	A	Protein	A	3
FT	#SUB	11	   9 	SER	B	74	  71 	ARG	A	Protein	S	1
FT	#SUB	11	   9 	SER	B	75	  72 	GLU	A	Protein	A	10
FT	#SUB	15	  13 	GLN	B	74	  71 	ARG	A	Protein	S	5
FT	#SUB	74	  72 	PHE	B	8	   5 	PHE	A	Protein	S	1
FT	#SUB	78	  76 	TYR	B	8	   5 	PHE	A	Protein	S	7
FT	#SUB	78	  76 	TYR	B	12	   9 	LEU	A	Protein	S	1
FT	#SUB	81	  79 	LYS	B	5	   2 	ASP	A	Protein	A	4
FT	#SUB	82	  80 	SER	B	4	   1 	MET	A	Protein	B	3
FT	#SUB	82	  80 	SER	B	5	   2 	ASP	A	Protein	B	3
FT	#SUB	82	  80 	SER	B	8	   5 	PHE	A	Protein	A	4
FT	#SUB	83	  81 	ILE	B	8	   5 	PHE	A	Protein	S	1
FT	#SUB	98	  96 	LYS	B	62	  59 	ILE	A	Protein	S	5
FT	#SUB	98	  96 	LYS	B	64	  61 	MET	A	Protein	B	3
FT	#SUB	98	  96 	LYS	B	67	  64 	CYS	A	Protein	A	3
FT	#SUB	98	  96 	LYS	B	68	  65 	ARG	A	Protein	B	1
FT	#SUB	99	  97 	VAL	B	67	  64 	CYS	A	Protein	A	3
FT	#SUB	99	  97 	VAL	B	68	  65 	ARG	A	Protein	B	2
FT	#SUB	101	  99 	GLU	B	64	  61 	MET	A	Protein	S	3
FT	#SUB	101	  99 	GLU	B	68	  65 	ARG	A	Protein	S	4
FT	#SUB	101	  99 	GLU	B	181	 178 	ARG	A	Protein	S	2
FT	#SUB	101	  99 	GLU	B	182	 179 	LEU	A	Protein	S	1
FT	#SUB	101	  99 	GLU	B	183	 180 	PHE	A	Protein	S	1
FT	#SUB	104	 102 	VAL	B	64	  61 	MET	A	Protein	S	1
FT	#SUB	132	 130 	TYR	B	3	   0 	LYS	A	Protein	S	1
FT	#SUB	136	 134 	HIS	B	1	  -2 	ASP	A	Protein	S	3
FT	#SUB	138	 136 	LEU	B	94	  91 	ARG	A	Protein	A	9
FT	#SUB	139	 137 	GLU	B	1	  -2 	ASP	A	Protein	S	5
FT	#SUB	141	 139 	GLU	B	62	  59 	ILE	A	Protein	S	4
FT	#SUB	142	 140 	PHE	B	62	  59 	ILE	A	Protein	S	2
FT	#SUB	142	 140 	PHE	B	89	  86 	LEU	A	Protein	B	1
FT	#SUB	142	 140 	PHE	B	90	  87 	SER	A	Protein	S	2
FT	#SUB	142	 140 	PHE	B	91	  88 	HIS	A	Protein	S	3
FT	#SUB	142	 140 	PHE	B	94	  91 	ARG	A	Protein	S	5
FT	#SUB	143	 141 	TYR	B	4	   1 	MET	A	Protein	S	3
FT	#SUB	143	 141 	TYR	B	8	   5 	PHE	A	Protein	S	1
FT	#SUB	143	 141 	TYR	B	9	   6 	LYS	A	Protein	S	3
FT	#SUB	143	 141 	TYR	B	12	   9 	LEU	A	Protein	S	2
FT	#SUB	145	 143 	LEU	B	62	  59 	ILE	A	Protein	S	1
FT	#SUB	146	 144 	GLU	B	16	  13 	ARG	A	Protein	S	7
FT	#SUB	146	 144 	GLU	B	89	  86 	LEU	A	Protein	B	1
FT	#SUB	149	 147 	ASP	B	74	  71 	ARG	A	Protein	A	5
FT	#SUB	150	 148 	CYS	B	70	  67 	ILE	A	Protein	A	2
FT	#SUB	150	 148 	CYS	B	74	  71 	ARG	A	Protein	B	3
FT	#SUB	150	 148 	CYS	B	87	  84 	VAL	A	Protein	S	3
FT	#SUB	151	 149 	CYS	B	74	  71 	ARG	A	Protein	S	3
FT	#SUB	152	 150 	LEU	B	67	  64 	CYS	A	Protein	S	1
FT	#SUB	152	 150 	LEU	B	71	  68 	ALA	A	Protein	S	1
FT	#SUB	153	 151 	ILE	B	71	  68 	ALA	A	Protein	S	1
FT	#SUB	153	 151 	ILE	B	75	  72 	GLU	A	Protein	S	2
FT	#SUB	262	 260 	PRO	B	3	   0 	LYS	A	Protein	S	6
FT	#SUB	262	 260 	PRO	B	4	   1 	MET	A	Protein	S	1
FT	#SUB	262	 260 	PRO	B	5	   2 	ASP	A	Protein	S	1
FT	#SUB	263	 261 	LYS	B	4	   1 	MET	A	Protein	B	1
FT	#SUB	263	 261 	LYS	B	5	   2 	ASP	A	Protein	A	7
FT	#SUB	263	 261 	LYS	B	6	   3 	TYR	A	Protein	B	2
FT	#SUB	263	 261 	LYS	B	7	   4 	ASP	A	Protein	S	3
FT	#SUB	264	 262 	PRO	B	6	   3 	TYR	A	Protein	B	1
FT	#SUB	265	 263 	PRO	B	6	   3 	TYR	A	Protein	B	1
FT	#SUB	266	 264 	PRO	B	6	   3 	TYR	A	Protein	S	2
FT	#HET	22	  20 	ASP	B	5	1265 	FMT	B	S	1
FT	#HET	51	  49 	GLN	B	6	1266 	FMT	B	S	2
FT	#HET	61	  59 	GLN	B	6	1266 	FMT	B	S	4
FT	#HET	65	  63 	ALA	B	6	1266 	FMT	B	A	3
FT	#HET	68	  66 	THR	B	6	1266 	FMT	B	S	1
FT	#HET	76	  74 	ALA	B	5	1265 	FMT	B	B	3
FT	#HET	77	  75 	ARG	B	5	1265 	FMT	B	A	3
FT	#HET	158	 156 	TYR	B	6	1266 	FMT	B	S	1
FT	#HET	183	 181 	ASN	B	6	1266 	FMT	B	B	1
FT	#HET	186	 184 	TYR	B	6	1266 	FMT	B	S	6
FT	DISORDER	267	285
CC	SEQUENCE	266 AA (ATOM);
CC	KAMAGNFWQS SHYLQWILDK QDLLKERQKD LKFLSEEEYW KLQIFFTNVI QALGEHLKLR
CC	QQVIATATVY FKRFYARYSL KSIDPVLMAP TCVFLASKVE EFGVVSNTRL IAAATSVLKT
CC	RFSYAFPKEF PYRMNHILEC EFYLLELMDC CLIVYHPYRP LLQYVQDMGQ EDMLLPLAWR
CC	IVNDTYRTDL CLLYPPFMIA LACLHVACVV QQKDARQWFA ELSVDMEKIL EIIRVILKLY
CC	EQWKNFDERK EMATILSKMP KPKPPP
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVI
CC	ATOM   KAMAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVI
CC	       **************************************************
CC	SEQRES QALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVE
CC	ATOM   QALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVE
CC	       **************************************************
CC	SEQRES EFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDC
CC	ATOM   EFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDC
CC	       **************************************************
CC	SEQRES CLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIA
CC	ATOM   CLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIA
CC	       **************************************************
CC	SEQRES LACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERK
CC	ATOM   LACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERK
CC	       **************************************************
CC	SEQRES EMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
CC	ATOM   EMATILSKMPKPKPPP-------------------
CC	       ****************                   
SQ	SEQUENCE	285 AA;      MW;         CN;
	KAMAGNFWQS SHYLQWILDK QDLLKERQKD LKFLSEEEYW KLQIFFTNVI QALGEHLKLR
	QQVIATATVY FKRFYARYSL KSIDPVLMAP TCVFLASKVE EFGVVSNTRL IAAATSVLKT
	RFSYAFPKEF PYRMNHILEC EFYLLELMDC CLIVYHPYRP LLQYVQDMGQ EDMLLPLAWR
	IVNDTYRTDL CLLYPPFMIA LACLHVACVV QQKDARQWFA ELSVDMEKIL EIIRVILKLY
	EQWKNFDERK EMATILSKMP KPKPPPNSEG EQGPNGSQNS SYSQS
//