Brand  (β version)

PDB ID: 4XV1

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Ligands
Code Name Style Show Link
904 N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-B]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide PoSSuM
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Structure summary

Code : 4XV1   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : B-Raf Kinase V600E oncogenic mutant in complex with PLX7904
Release Data : 2015-10-28
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase B-raf A,B Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
ec: 2.7.11.1
fragment: UNP RESIDUES 444-705
mutation: S446A,S447A,I543A,I544S,I551K,Q562R,L588N,V600E,K630S,F667E,Y673S,A688R
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRAF, BRAF1, RAFB1
Authors : Zhang, Y., Zhang, C.
Keywords : B-RAF, BRAF, PROTO-ONCOGENE, V600E, KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.47 Å )
Citation :

RAF inhibitors that evade paradoxical MAPK pathway activation.

Zhang, C.,Spevak, W.,Zhang, Y.  et al.
(2015)  Nature  526 : 583 - 586

PubMed: 26466569
DOI: 10.1038/nature14982

Reaction

Chain : A, B
UniProt : P15056 (BRAF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:21441910, PubMed:29433126
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:21441910
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000250
Binds 2 Zn(2+) ions per subunit.