PDB ID: 4XV1
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904 | N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-B]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide | PoSSuM |
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Download interaction data: 4XV1
Structure summary
Code : | 4XV1 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | B-Raf Kinase V600E oncogenic mutant in complex with PLX7904 | ||||||||||||
Release Data : | 2015-10-28 | ||||||||||||
Compound : |
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Authors : | Zhang, Y., Zhang, C. | ||||||||||||
Keywords : | B-RAF, BRAF, PROTO-ONCOGENE, V600E, KINASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.47 Å ) | ||||||||||||
Citation : |
RAF inhibitors that evade paradoxical MAPK pathway activation.
Zhang, C.,Spevak, W.,Zhang, Y.
et al.
PubMed: 26466569 |
Reaction
Chain : | A, B | ||||||||||||
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UniProt : | P15056 (BRAF_HUMAN) | ||||||||||||
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