ID	4XV1A	STANDARD;	PRT;	292	AA.
DT	CONVERTED FROM PDB (SEQRES) 4XV1
DE	Serine/threonine-protein kinase B-raf
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.470
CC	R-Factor	0.236
FT	#SUB	19	 450 	TRP	A	75	 506 	ARG	B	Protein	S	2
FT	#SUB	19	 450 	TRP	A	76	 507 	LYS	B	Protein	S	4
FT	#SUB	19	 450 	TRP	A	77	 508 	THR	B	Protein	S	2
FT	#SUB	19	 450 	TRP	A	78	 509 	ARG	B	Protein	S	9
FT	#SUB	19	 450 	TRP	A	135	 566 	TYR	B	Protein	S	1
FT	#SUB	19	 450 	TRP	A	139	 570 	LYS	B	Protein	S	2
FT	#SUB	44	 475 	LYS	A	131	 562 	ARG	B	Protein	S	1
FT	#SUB	45	 476 	TRP	A	135	 566 	TYR	B	Protein	S	2
FT	#SUB	46	 477 	HIS	A	79	 510 	HIS	B	Protein	B	3
FT	#SUB	46	 477 	HIS	A	131	 562 	ARG	B	Protein	B	1
FT	#SUB	46	 477 	HIS	A	134	 565 	ASP	B	Protein	A	7
FT	#SUB	46	 477 	HIS	A	135	 566 	TYR	B	Protein	S	1
FT	#SUB	46	 477 	HIS	A	138	 569 	ALA	B	Protein	S	2
FT	#SUB	47	 478 	GLY	A	131	 562 	ARG	B	Protein	B	3
FT	#SUB	48	 479 	ASP	A	131	 562 	ARG	B	Protein	A	3
FT	#SUB	75	 506 	ARG	A	19	 450 	TRP	B	Protein	B	2
FT	#SUB	75	 506 	ARG	A	78	 509 	ARG	B	Protein	B	3
FT	#SUB	76	 507 	LYS	A	19	 450 	TRP	B	Protein	B	5
FT	#SUB	77	 508 	THR	A	19	 450 	TRP	B	Protein	B	1
FT	#SUB	77	 508 	THR	A	78	 509 	ARG	B	Protein	B	5
FT	#SUB	78	 509 	ARG	A	19	 450 	TRP	B	Protein	S	12
FT	#SUB	78	 509 	ARG	A	74	 505 	LEU	B	Protein	S	1
FT	#SUB	78	 509 	ARG	A	75	 506 	ARG	B	Protein	S	4
FT	#SUB	78	 509 	ARG	A	77	 508 	THR	B	Protein	S	5
FT	#SUB	78	 509 	ARG	A	78	 509 	ARG	B	Protein	S	5
FT	#SUB	78	 509 	ARG	A	85	 516 	PHE	B	Protein	S	12
FT	#SUB	78	 509 	ARG	A	86	 517 	MET	B	Protein	B	3
FT	#SUB	79	 510 	HIS	A	46	 477 	HIS	B	Protein	S	4
FT	#SUB	79	 510 	HIS	A	84	 515 	LEU	B	Protein	B	3
FT	#SUB	80	 511 	VAL	A	84	 515 	LEU	B	Protein	B	1
FT	#SUB	80	 511 	VAL	A	99	 530 	GLN	B	Protein	S	1
FT	#SUB	84	 515 	LEU	A	78	 509 	ARG	B	Protein	S	2
FT	#SUB	84	 515 	LEU	A	79	 510 	HIS	B	Protein	S	3
FT	#SUB	84	 515 	LEU	A	80	 511 	VAL	B	Protein	S	1
FT	#SUB	84	 515 	LEU	A	84	 515 	LEU	B	Protein	S	1
FT	#SUB	85	 516 	PHE	A	78	 509 	ARG	B	Protein	A	5
FT	#SUB	86	 517 	MET	A	78	 509 	ARG	B	Protein	S	3
FT	#SUB	86	 517 	MET	A	79	 510 	HIS	B	Protein	S	1
FT	#SUB	99	 530 	GLN	A	80	 511 	VAL	B	Protein	S	1
FT	#SUB	131	 562 	ARG	A	44	 475 	LYS	B	Protein	S	1
FT	#SUB	131	 562 	ARG	A	46	 477 	HIS	B	Protein	A	2
FT	#SUB	131	 562 	ARG	A	47	 478 	GLY	B	Protein	S	3
FT	#SUB	131	 562 	ARG	A	48	 479 	ASP	B	Protein	S	3
FT	#SUB	134	 565 	ASP	A	46	 477 	HIS	B	Protein	A	3
FT	#SUB	135	 566 	TYR	A	19	 450 	TRP	B	Protein	S	1
FT	#SUB	135	 566 	TYR	A	45	 476 	TRP	B	Protein	S	2
FT	#SUB	138	 569 	ALA	A	46	 477 	HIS	B	Protein	S	2
FT	#SUB	139	 570 	LYS	A	18	 449 	ASP	B	Protein	S	1
FT	#SUB	139	 570 	LYS	A	19	 450 	TRP	B	Protein	S	2
FT	#SUB	155	 586 	GLU	A	157	 588 	ASN	B	Protein	S	1
FT	#SUB	155	 586 	GLU	A	158	 589 	THR	B	Protein	S	3
FT	#SUB	157	 588 	ASN	A	155	 586 	GLU	B	Protein	S	4
FT	#SUB	158	 589 	THR	A	155	 586 	GLU	B	Protein	S	3
FT	#SUB	284	 715 	GLU	A	44	 475 	LYS	B	Protein	S	2
FT	#HET	32	 463 	ILE	A	1	801 	904	A	S	4
FT	#HET	40	 471 	VAL	A	1	801 	904	A	S	3
FT	#HET	50	 481 	ALA	A	1	801 	904	A	A	7
FT	#HET	52	 483 	LYS	A	1	801 	904	A	A	8
FT	#HET	74	 505 	LEU	A	1	801 	904	A	S	4
FT	#HET	83	 514 	LEU	A	1	801 	904	A	A	13
FT	#HET	85	 516 	PHE	A	1	801 	904	A	B	1
FT	#HET	96	 527 	ILE	A	1	801 	904	A	S	1
FT	#HET	98	 529 	THR	A	1	801 	904	A	S	7
FT	#HET	99	 530 	GLN	A	1	801 	904	A	B	3
FT	#HET	100	 531 	TRP	A	1	801 	904	A	A	6
FT	#HET	101	 532 	CYS	A	1	801 	904	A	A	9
FT	#HET	152	 583 	PHE	A	1	801 	904	A	S	2
FT	#HET	162	 593 	GLY	A	1	801 	904	A	B	2
FT	#HET	163	 594 	ASP	A	1	801 	904	A	A	10
FT	#HET	164	 595 	PHE	A	1	801 	904	A	B	3
FT	#HET	165	 596 	GLY	A	1	801 	904	A	B	2
FT	DISORDER	1	17
FT	DISORDER	35	37
FT	DISORDER	57	57
FT	DISORDER	114	115
FT	DISORDER	166	182
FT	DISORDER	196	199
FT	DISORDER	251	252
FT	DISORDER	286	292
CC	SEQUENCE	239 AA (ATOM);
CC	DWEIPDGQIT VGQRIGSGTV YKGKWHGDVA VKMLNVAPTP QQLQAFKNEV GVLRKTRHVN
CC	ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH ASKFEMKKLI DIARQTARGM DYLHAKSIIH
CC	RDLKSNNIFL HEDNTVKIGD FGSGSILWMA PEVIRNPYSF QSDVYAFGIV LYELMTGQLP
CC	YSNINNRDQI IEMVGRGSLS PDLSKVNCPK RMKRLMAECL KKKRDERPSF PRILAEIEE
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MKKGHHHHHHGSRDAADDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
CC	ATOM   -----------------DWEIPDGQITVGQRIGS---GTVYKGKWHGDVA
CC	                        *****************   *************
CC	SEQRES VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW
CC	ATOM   VKMLNV-APTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW
CC	       ****** *******************************************
CC	SEQRES CEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNN
CC	ATOM   CEGSSLYHHLHAS--KFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNN
CC	       *************  ***********************************
CC	SEQRES IFLHEDNTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDSN
CC	ATOM   IFLHEDNTVKIGDFG-----------------SGSILWMAPEVIR----N
CC	       ***************                 *************    *
CC	SEQRES PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKV
CC	ATOM   PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKV
CC	       **************************************************
CC	SEQRES RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELSG
CC	ATOM   --NCPKRMKRLMAECLKKKRDERPSFPRILAEIEE-------
CC	         *********************************       
SQ	SEQUENCE	292 AA;      MW;         CN;
	MKKGHHHHHH GSRDAADDWE IPDGQITVGQ RIGSGSFGTV YKGKWHGDVA VKMLNVTAPT
	PQQLQAFKNE VGVLRKTRHV NILLFMGYST KPQLAIVTQW CEGSSLYHHL HASETKFEMK
	KLIDIARQTA RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK IGDFGLATEK SRWSGSHQFE
	QLSGSILWMA PEVIRMQDSN PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR
	GSLSPDLSKV RSNCPKRMKR LMAECLKKKR DERPSFPRIL AEIEELAREL SG
//
ID	4XV1B	STANDARD;	PRT;	292	AA.
DT	CONVERTED FROM PDB (SEQRES) 4XV1
DE	Serine/threonine-protein kinase B-raf
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.470
CC	R-Factor	0.236
FT	#SUB	18	 449 	ASP	B	139	 570 	LYS	A	Protein	B	1
FT	#SUB	19	 450 	TRP	B	75	 506 	ARG	A	Protein	S	2
FT	#SUB	19	 450 	TRP	B	76	 507 	LYS	A	Protein	S	5
FT	#SUB	19	 450 	TRP	B	77	 508 	THR	A	Protein	S	1
FT	#SUB	19	 450 	TRP	B	78	 509 	ARG	A	Protein	S	12
FT	#SUB	19	 450 	TRP	B	135	 566 	TYR	A	Protein	S	1
FT	#SUB	19	 450 	TRP	B	139	 570 	LYS	A	Protein	S	2
FT	#SUB	44	 475 	LYS	B	131	 562 	ARG	A	Protein	S	1
FT	#SUB	44	 475 	LYS	B	284	 715 	GLU	A	Protein	S	2
FT	#SUB	45	 476 	TRP	B	135	 566 	TYR	A	Protein	S	2
FT	#SUB	46	 477 	HIS	B	79	 510 	HIS	A	Protein	B	4
FT	#SUB	46	 477 	HIS	B	131	 562 	ARG	A	Protein	B	2
FT	#SUB	46	 477 	HIS	B	134	 565 	ASP	A	Protein	S	3
FT	#SUB	46	 477 	HIS	B	138	 569 	ALA	A	Protein	S	2
FT	#SUB	47	 478 	GLY	B	131	 562 	ARG	A	Protein	B	3
FT	#SUB	48	 479 	ASP	B	131	 562 	ARG	A	Protein	S	3
FT	#SUB	74	 505 	LEU	B	78	 509 	ARG	A	Protein	B	1
FT	#SUB	75	 506 	ARG	B	19	 450 	TRP	A	Protein	B	2
FT	#SUB	75	 506 	ARG	B	78	 509 	ARG	A	Protein	B	4
FT	#SUB	76	 507 	LYS	B	19	 450 	TRP	A	Protein	B	4
FT	#SUB	77	 508 	THR	B	19	 450 	TRP	A	Protein	B	2
FT	#SUB	77	 508 	THR	B	78	 509 	ARG	A	Protein	B	5
FT	#SUB	78	 509 	ARG	B	19	 450 	TRP	A	Protein	A	9
FT	#SUB	78	 509 	ARG	B	75	 506 	ARG	A	Protein	S	3
FT	#SUB	78	 509 	ARG	B	77	 508 	THR	A	Protein	S	5
FT	#SUB	78	 509 	ARG	B	78	 509 	ARG	A	Protein	S	5
FT	#SUB	78	 509 	ARG	B	84	 515 	LEU	A	Protein	A	2
FT	#SUB	78	 509 	ARG	B	85	 516 	PHE	A	Protein	S	5
FT	#SUB	78	 509 	ARG	B	86	 517 	MET	A	Protein	B	3
FT	#SUB	79	 510 	HIS	B	46	 477 	HIS	A	Protein	S	3
FT	#SUB	79	 510 	HIS	B	84	 515 	LEU	A	Protein	B	3
FT	#SUB	79	 510 	HIS	B	86	 517 	MET	A	Protein	S	1
FT	#SUB	80	 511 	VAL	B	84	 515 	LEU	A	Protein	B	1
FT	#SUB	80	 511 	VAL	B	99	 530 	GLN	A	Protein	S	1
FT	#SUB	84	 515 	LEU	B	79	 510 	HIS	A	Protein	S	3
FT	#SUB	84	 515 	LEU	B	80	 511 	VAL	A	Protein	S	1
FT	#SUB	84	 515 	LEU	B	84	 515 	LEU	A	Protein	S	1
FT	#SUB	85	 516 	PHE	B	78	 509 	ARG	A	Protein	A	12
FT	#SUB	86	 517 	MET	B	78	 509 	ARG	A	Protein	S	3
FT	#SUB	99	 530 	GLN	B	80	 511 	VAL	A	Protein	S	1
FT	#SUB	131	 562 	ARG	B	44	 475 	LYS	A	Protein	S	1
FT	#SUB	131	 562 	ARG	B	46	 477 	HIS	A	Protein	S	1
FT	#SUB	131	 562 	ARG	B	47	 478 	GLY	A	Protein	S	3
FT	#SUB	131	 562 	ARG	B	48	 479 	ASP	A	Protein	S	3
FT	#SUB	134	 565 	ASP	B	46	 477 	HIS	A	Protein	A	7
FT	#SUB	135	 566 	TYR	B	19	 450 	TRP	A	Protein	S	1
FT	#SUB	135	 566 	TYR	B	45	 476 	TRP	A	Protein	S	2
FT	#SUB	135	 566 	TYR	B	46	 477 	HIS	A	Protein	S	1
FT	#SUB	138	 569 	ALA	B	46	 477 	HIS	A	Protein	S	2
FT	#SUB	139	 570 	LYS	B	19	 450 	TRP	A	Protein	S	2
FT	#SUB	155	 586 	GLU	B	157	 588 	ASN	A	Protein	S	4
FT	#SUB	155	 586 	GLU	B	158	 589 	THR	A	Protein	S	3
FT	#SUB	157	 588 	ASN	B	155	 586 	GLU	A	Protein	S	1
FT	#SUB	158	 589 	THR	B	155	 586 	GLU	A	Protein	S	3
FT	DISORDER	1	17
FT	DISORDER	34	38
FT	DISORDER	170	184
FT	DISORDER	196	199
FT	DISORDER	291	292
CC	SEQUENCE	249 AA (ATOM);
CC	DWEIPDGQIT VGQRIGTVYK GKWHGDVAVK MLNVTAPTPQ QLQAFKNEVG VLRKTRHVNI
CC	LLFMGYSTKP QLAIVTQWCE GSSLYHHLHA SETKFEMKKL IDIARQTARG MDYLHAKSII
CC	HRDLKSNNIF LHEDNTVKIG DFGLATESIL WMAPEVIRNP YSFQSDVYAF GIVLYELMTG
CC	QLPYSNINNR DQIIEMVGRG SLSPDLSKVR SNCPKRMKRL MAECLKKKRD ERPSFPRILA
CC	EIEELAREL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MKKGHHHHHHGSRDAADDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
CC	ATOM   -----------------DWEIPDGQITVGQRIG-----TVYKGKWHGDVA
CC	                        ****************     ************
CC	SEQRES VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW
CC	ATOM   VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQW
CC	       **************************************************
CC	SEQRES CEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNN
CC	ATOM   CEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNN
CC	       **************************************************
CC	SEQRES IFLHEDNTVKIGDFGLATEKSRWSGSHQFEQLSGSILWMAPEVIRMQDSN
CC	ATOM   IFLHEDNTVKIGDFGLATE---------------SILWMAPEVIR----N
CC	       *******************               ***********    *
CC	SEQRES PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKV
CC	ATOM   PYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKV
CC	       **************************************************
CC	SEQRES RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELSG
CC	ATOM   RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL--
CC	       ****************************************  
SQ	SEQUENCE	292 AA;      MW;         CN;
	MKKGHHHHHH GSRDAADDWE IPDGQITVGQ RIGSGSFGTV YKGKWHGDVA VKMLNVTAPT
	PQQLQAFKNE VGVLRKTRHV NILLFMGYST KPQLAIVTQW CEGSSLYHHL HASETKFEMK
	KLIDIARQTA RGMDYLHAKS IIHRDLKSNN IFLHEDNTVK IGDFGLATEK SRWSGSHQFE
	QLSGSILWMA PEVIRMQDSN PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR
	GSLSPDLSKV RSNCPKRMKR LMAECLKKKR DERPSFPRIL AEIEELAREL SG
//