Brand  (β version)

PDB ID: 4UXQ

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Ligands
Code Name Style Show Link
0LI 3-(imidazo[1,2-B]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4UXQ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : FGFR4 in complex with Ponatinib
Release Data : 2014-12-03
Compound :
mol_id molecule chains synonym
1 FIBROBLAST GROWTH FACTOR RECEPTOR 4 A FGFR-4, FGFR4, CD334
ec: 2.7.10.1
fragment: KINASE DOMAIN, RESIDUES 447-753
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
Authors : Tucker, J., Klein, T., Breed, J., Breeze, A., Overman, R., Phillips, C., Norman, R.A.
Keywords : TRANSFERASE, KINASE DFG-OUT FGFR INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Structural Insights Into Fgfr Kinase Isoform Selectivity: Diverse Binding Modes of Azd4547 and Ponatinib in Complex with Fgfr1 and Fgfr4

Tucker, J.A.,Klein, T.,Breed, J.  et al.
(2014)  Structure  22 : 1764

PubMed: 25465127
DOI: 10.1016/J.STR.2014.09.019

Reaction

Chain : A
UniProt : P22455 (FGFR4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:11433297, PubMed:17311277, PubMed:18480409, PubMed:18670643
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