Brand  (β version)

PDB ID: 4TYJ

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Ligands
Code Name Style Show Link
0LI 3-(imidazo[1,2-B]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide PoSSuM
EDO 1,2-ethanediol PoSSuM
PO4 Phosphate ion PoSSuM
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Structure summary

Code : 4TYJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase
Release Data : 2014-09-24
Compound :
mol_id molecule chains synonym
1 Fibroblast growth factor receptor 4 A FGFR-4
ec: 2.7.10.1
fragment: UNP residues 447-753
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: FGFR4, JTK2, TKF
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector_type: Baculovirus
expression_system_plasmid: pFastBac HTB
Authors : Lesca, E., Lammens, A., Huber, R., Augustin, M.
Keywords : Fibroblast growth factor receptor, Kinase, Transferase, Dovitinib, Ponatinb, Proteros Biostructures GmbH
Exp. method : X-RAY DIFFRACTION ( 2.45 Å )
Citation :

Structural analysis of the human fibroblast growth factor receptor 4 kinase.

Lesca, E.,Lammens, A.,Huber, R.  et al.
(2014)  J.Mol.Biol.  426 : 3744 - 3756

PubMed: 25219510
DOI: 10.1016/j.jmb.2014.09.004

Reaction

Chain : A
UniProt : P22455 (FGFR4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:11433297, PubMed:17311277, PubMed:18480409, PubMed:18670643
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