Brand  (β version)

PDB ID: 4RZV

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Ligands
Code Name Style Show Link
032 N-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-B]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide PoSSuM
Non-standard Residues
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Structure summary

Code : 4RZV   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Crystal structure of the BRAF (R509H) kinase domain monomer bound to Vemurafenib
Release Data : 2016-08-10
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase B-raf A,B Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
ec: 2.7.11.1
fragment: Protein kinase domain residues 443-723
mutation: R509H, I543A, I544S, I551K, Q562R, L588N, K630S, F667E, Y673S, A688R, L706S, Q709R, S713E, L716E, S720E, P722S, K723G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: BRAF, BRAF1, RAFB1
Authors : Wu, Y., Gavathiotis, E.
Keywords : Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.994 Å )
Citation :

An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling

Karoulia, Z.,Wu, Y.,Ahmed, T.A.  et al.
(2016)  Cancer Cell  30 : 1 - 14

Reaction

Chain : A, B
UniProt : P15056 (BRAF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:21441910, PubMed:29433126
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:21441910
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000250
Binds 2 Zn(2+) ions per subunit.