ID	4RZVA	STANDARD;	PRT;	281	AA.
DT	CONVERTED FROM PDB (SEQRES) 4RZV
DE	Serine/threonine-protein kinase B-raf
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.990
CC	R-Factor	0.207
FT	#SUB	123	 565 	ASP	A	68	 510 	HIS	B	Protein	S	8
FT	#SUB	123	 565 	ASP	A	69	 511 	VAL	B	Protein	S	2
FT	#SUB	123	 565 	ASP	A	120	 562 	ARG	B	Protein	A	9
FT	#SUB	124	 566 	TYR	A	69	 511 	VAL	B	Protein	S	1
FT	#SUB	126	 568 	HIS	A	116	 558 	ARG	B	Protein	B	5
FT	#SUB	126	 568 	HIS	A	120	 562 	ARG	B	Protein	S	1
FT	#SUB	127	 569 	ALA	A	69	 511 	VAL	B	Protein	S	1
FT	#SUB	127	 569 	ALA	A	70	 512 	ASN	B	Protein	S	1
FT	#SUB	127	 569 	ALA	A	116	 558 	ARG	B	Protein	B	3
FT	#SUB	127	 569 	ALA	A	117	 559 	GLN	B	Protein	B	4
FT	#SUB	127	 569 	ALA	A	120	 562 	ARG	B	Protein	A	6
FT	#SUB	128	 570 	LYS	A	145	 587 	ASP	B	Protein	S	2
FT	#SUB	128	 570 	LYS	A	147	 589 	THR	B	Protein	S	1
FT	#SUB	129	 571 	SER	A	116	 558 	ARG	B	Protein	A	3
FT	#SUB	192	 634 	SER	A	277	 719 	ARG	B	Protein	A	4
FT	#SUB	193	 635 	PHE	A	273	 715 	GLU	B	Protein	S	6
FT	#SUB	194	 636 	GLN	A	277	 719 	ARG	B	Protein	S	1
FT	#SUB	259	 701 	ARG	A	274	 716 	GLU	B	Protein	S	3
FT	#SUB	264	 706 	SER	A	123	 565 	ASP	B	Protein	S	3
FT	#SUB	264	 706 	SER	A	269	 711 	LEU	B	Protein	S	2
FT	#SUB	266	 708 	PRO	A	68	 510 	HIS	B	Protein	A	3
FT	#SUB	266	 708 	PRO	A	120	 562 	ARG	B	Protein	S	5
FT	#SUB	266	 708 	PRO	A	124	 566 	TYR	B	Protein	B	1
FT	#SUB	267	 709 	ARG	A	123	 565 	ASP	B	Protein	S	8
FT	#SUB	267	 709 	ARG	A	127	 569 	ALA	B	Protein	S	1
FT	#SUB	267	 709 	ARG	A	266	 708 	PRO	B	Protein	S	3
FT	#SUB	270	 712 	ALA	A	124	 566 	TYR	B	Protein	S	2
FT	#SUB	270	 712 	ALA	A	127	 569 	ALA	B	Protein	S	1
FT	#SUB	273	 715 	GLU	A	67	 509 	HIS	B	Protein	S	1
FT	#SUB	273	 715 	GLU	A	124	 566 	TYR	B	Protein	S	4
FT	#SUB	273	 715 	GLU	A	128	 570 	LYS	B	Protein	S	5
FT	#SUB	277	 719 	ARG	A	65	 507 	LYS	B	Protein	S	6
FT	#HET	21	 463 	ILE	A	1	801 	032	A	S	3
FT	#HET	29	 471 	VAL	A	1	801 	032	A	S	5
FT	#HET	39	 481 	ALA	A	1	801 	032	A	A	6
FT	#HET	40	 482 	VAL	A	1	801 	032	A	B	2
FT	#HET	41	 483 	LYS	A	1	801 	032	A	A	12
FT	#HET	72	 514 	LEU	A	1	801 	032	A	A	8
FT	#HET	74	 516 	PHE	A	1	801 	032	A	S	1
FT	#HET	85	 527 	ILE	A	1	801 	032	A	A	3
FT	#HET	87	 529 	THR	A	1	801 	032	A	S	9
FT	#HET	88	 530 	GLN	A	1	801 	032	A	B	1
FT	#HET	89	 531 	TRP	A	1	801 	032	A	S	7
FT	#HET	90	 532 	CYS	A	1	801 	032	A	A	4
FT	#HET	93	 535 	SER	A	1	801 	032	A	A	5
FT	#HET	94	 536 	SER	A	1	801 	032	A	A	4
FT	#HET	97	 539 	HIS	A	1	801 	032	A	S	3
FT	#HET	141	 583 	PHE	A	1	801 	032	A	S	17
FT	#HET	151	 593 	GLY	A	1	801 	032	A	B	4
FT	#HET	152	 594 	ASP	A	1	801 	032	A	B	8
FT	#HET	153	 595 	PHE	A	1	801 	032	A	A	6
FT	#HET	154	 596 	GLY	A	1	801 	032	A	B	2
FT	DISORDER	1	6
FT	DISORDER	159	170
FT	DISORDER	280	281
CC	SEQUENCE	261 AA (ATOM);
CC	DWEIPDGQIT VGQRIGSGSF GTVYKGKWHG DVAVKMLNVT APTPQQLQAF KNEVGVLRKT
CC	HHVNILLFMG YSTKPQLAIV TQWCEGSSLY HHLHASETKF EMKKLIDIAR QTARGMDYLH
CC	AKSIIHRDLK SNNIFLHEDN TVKIGDFGLA TVLSGSILWM APEVIRMQDS NPYSFQSDVY
CC	AFGIVLYELM TGQLPYSNIN NRDQIIEMVG RGSLSPDLSK VRSNCPKRMK RLMAECLKKK
CC	RDERPSFPRI LAEIEELARE L
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES RRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	ATOM   ------DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	             ********************************************
CC	SEQRES QQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	ATOM   QQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	       **************************************************
CC	SEQRES ASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKI
CC	ATOM   ASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKI
CC	       **************************************************
CC	SEQRES GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAF
CC	ATOM   GDFGLATV------------LSGSILWMAPEVIRMQDSNPYSFQSDVYAF
CC	       ********            ******************************
CC	SEQRES GIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRL
CC	ATOM   GIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRL
CC	       **************************************************
CC	SEQRES MAECLKKKRDERPSFPRILAEIEELARELSG
CC	ATOM   MAECLKKKRDERPSFPRILAEIEELAREL--
CC	       *****************************  
SQ	SEQUENCE	281 AA;      MW;         CN;
	RRDSSDDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV
	GVLRKTHHVN ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH ASETKFEMKK LIDIARQTAR
	GMDYLHAKSI IHRDLKSNNI FLHEDNTVKI GDFGLATVKS RWSGSHQFEQ LSGSILWMAP
	EVIRMQDSNP YSFQSDVYAF GIVLYELMTG QLPYSNINNR DQIIEMVGRG SLSPDLSKVR
	SNCPKRMKRL MAECLKKKRD ERPSFPRILA EIEELARELS G
//
ID	4RZVB	STANDARD;	PRT;	281	AA.
DT	CONVERTED FROM PDB (SEQRES) 4RZV
DE	Serine/threonine-protein kinase B-raf
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.990
CC	R-Factor	0.207
FT	#SUB	65	 507 	LYS	B	277	 719 	ARG	A	Protein	A	6
FT	#SUB	67	 509 	HIS	B	273	 715 	GLU	A	Protein	B	1
FT	#SUB	68	 510 	HIS	B	123	 565 	ASP	A	Protein	S	8
FT	#SUB	68	 510 	HIS	B	266	 708 	PRO	A	Protein	S	3
FT	#SUB	69	 511 	VAL	B	123	 565 	ASP	A	Protein	S	2
FT	#SUB	69	 511 	VAL	B	124	 566 	TYR	A	Protein	S	1
FT	#SUB	69	 511 	VAL	B	127	 569 	ALA	A	Protein	S	1
FT	#SUB	70	 512 	ASN	B	127	 569 	ALA	A	Protein	S	1
FT	#SUB	116	 558 	ARG	B	126	 568 	HIS	A	Protein	S	5
FT	#SUB	116	 558 	ARG	B	127	 569 	ALA	A	Protein	S	3
FT	#SUB	116	 558 	ARG	B	129	 571 	SER	A	Protein	S	3
FT	#SUB	117	 559 	GLN	B	127	 569 	ALA	A	Protein	S	4
FT	#SUB	120	 562 	ARG	B	123	 565 	ASP	A	Protein	S	9
FT	#SUB	120	 562 	ARG	B	126	 568 	HIS	A	Protein	S	1
FT	#SUB	120	 562 	ARG	B	127	 569 	ALA	A	Protein	S	6
FT	#SUB	120	 562 	ARG	B	266	 708 	PRO	A	Protein	A	5
FT	#SUB	123	 565 	ASP	B	264	 706 	SER	A	Protein	S	3
FT	#SUB	123	 565 	ASP	B	267	 709 	ARG	A	Protein	S	8
FT	#SUB	124	 566 	TYR	B	266	 708 	PRO	A	Protein	S	1
FT	#SUB	124	 566 	TYR	B	270	 712 	ALA	A	Protein	S	2
FT	#SUB	124	 566 	TYR	B	273	 715 	GLU	A	Protein	S	4
FT	#SUB	127	 569 	ALA	B	267	 709 	ARG	A	Protein	S	1
FT	#SUB	127	 569 	ALA	B	270	 712 	ALA	A	Protein	S	1
FT	#SUB	128	 570 	LYS	B	273	 715 	GLU	A	Protein	S	5
FT	#SUB	145	 587 	ASP	B	128	 570 	LYS	A	Protein	B	2
FT	#SUB	147	 589 	THR	B	128	 570 	LYS	A	Protein	S	1
FT	#SUB	266	 708 	PRO	B	267	 709 	ARG	A	Protein	S	3
FT	#SUB	269	 711 	LEU	B	264	 706 	SER	A	Protein	S	2
FT	#SUB	273	 715 	GLU	B	193	 635 	PHE	A	Protein	S	6
FT	#SUB	274	 716 	GLU	B	259	 701 	ARG	A	Protein	S	3
FT	#SUB	277	 719 	ARG	B	192	 634 	SER	A	Protein	S	4
FT	#SUB	277	 719 	ARG	B	194	 636 	GLN	A	Protein	S	1
FT	#HET	21	 463 	ILE	B	2	801 	032	B	S	6
FT	#HET	29	 471 	VAL	B	2	801 	032	B	S	5
FT	#HET	39	 481 	ALA	B	2	801 	032	B	A	9
FT	#HET	40	 482 	VAL	B	2	801 	032	B	B	4
FT	#HET	41	 483 	LYS	B	2	801 	032	B	A	12
FT	#HET	72	 514 	LEU	B	2	801 	032	B	A	6
FT	#HET	74	 516 	PHE	B	2	801 	032	B	S	1
FT	#HET	85	 527 	ILE	B	2	801 	032	B	B	1
FT	#HET	87	 529 	THR	B	2	801 	032	B	S	11
FT	#HET	88	 530 	GLN	B	2	801 	032	B	B	4
FT	#HET	89	 531 	TRP	B	2	801 	032	B	A	7
FT	#HET	90	 532 	CYS	B	2	801 	032	B	A	6
FT	#HET	93	 535 	SER	B	2	801 	032	B	A	6
FT	#HET	94	 536 	SER	B	2	801 	032	B	A	4
FT	#HET	97	 539 	HIS	B	2	801 	032	B	S	3
FT	#HET	141	 583 	PHE	B	2	801 	032	B	S	15
FT	#HET	151	 593 	GLY	B	2	801 	032	B	B	2
FT	#HET	152	 594 	ASP	B	2	801 	032	B	A	11
FT	#HET	153	 595 	PHE	B	2	801 	032	B	A	5
FT	#HET	154	 596 	GLY	B	2	801 	032	B	B	2
FT	DISORDER	1	6
FT	DISORDER	187	189
FT	DISORDER	281	281
CC	SEQUENCE	271 AA (ATOM);
CC	DWEIPDGQIT VGQRIGSGSF GTVYKGKWHG DVAVKMLNVT APTPQQLQAF KNEVGVLRKT
CC	HHVNILLFMG YSTKPQLAIV TQWCEGSSLY HHLHASETKF EMKKLIDIAR QTARGMDYLH
CC	AKSIIHRDLK SNNIFLHEDN TVKIGDFGLA TVKSRWSGSH QFEQLSGSIL WMAPEVIRMQ
CC	PYSFQSDVYA FGIVLYELMT GQLPYSNINN RDQIIEMVGR GSLSPDLSKV RSNCPKRMKR
CC	LMAECLKKKR DERPSFPRIL AEIEELAREL S
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES RRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	ATOM   ------DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTP
CC	             ********************************************
CC	SEQRES QQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	ATOM   QQLQAFKNEVGVLRKTHHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
CC	       **************************************************
CC	SEQRES ASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKI
CC	ATOM   ASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKI
CC	       **************************************************
CC	SEQRES GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAF
CC	ATOM   GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQ---PYSFQSDVYAF
CC	       ************************************   ***********
CC	SEQRES GIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRL
CC	ATOM   GIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRL
CC	       **************************************************
CC	SEQRES MAECLKKKRDERPSFPRILAEIEELARELSG
CC	ATOM   MAECLKKKRDERPSFPRILAEIEELARELS-
CC	       ****************************** 
SQ	SEQUENCE	281 AA;      MW;         CN;
	RRDSSDDWEI PDGQITVGQR IGSGSFGTVY KGKWHGDVAV KMLNVTAPTP QQLQAFKNEV
	GVLRKTHHVN ILLFMGYSTK PQLAIVTQWC EGSSLYHHLH ASETKFEMKK LIDIARQTAR
	GMDYLHAKSI IHRDLKSNNI FLHEDNTVKI GDFGLATVKS RWSGSHQFEQ LSGSILWMAP
	EVIRMQDSNP YSFQSDVYAF GIVLYELMTG QLPYSNINNR DQIIEMVGRG SLSPDLSKVR
	SNCPKRMKRL MAECLKKKRD ERPSFPRILA EIEELARELS G
//