Brand  (β version)

PDB ID: 4R09

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Ligands
Code Name Style Show Link
URI Uridine PoSSuM
06S O-[(2r,3s,4r,5r)-5-(2-amino-6-oxo-3,6-dihydro-9h-purin-9-yl)-2-({[(S)-({(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-4-hydroxy-2-[(thiophosphonooxy)methyl]tetrahydrofuran-3-yl}oxy)(sulfanyl)phosphoryl]oxy}methyl)-4-hydroxytetrahydrofuran-3-yl] dihydrogen (S)-phosphorothioate PoSSuM
UPT 1-[(2r,3ar,4r,6r,6ar)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-D][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1h,3h)-dione PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
Modification
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Structure summary

Code : 4R09   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Crystal structure of human TLR8 in complex with ORN06S
Release Data : 2015-01-14
Compound :
mol_id molecule chains
1 Toll-like receptor 8 A,B,C,D
fragment: Extracellular domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human DROSOPHILA MELANOGASTER  (taxid:7227)
gene: TLR8, UNQ249/PRO286
expression_system_cell_line: SCHNEIDER 2(S2) CELLS
expression_system_vector_type: baculovirus
Authors : Tanji, H., Ohto, U., Shimizu, T.
Keywords : Leucine rich repeat, RNA, Glycosylation, innate immunity, RNA recognition, ssRNA, RNA receptor, RNA binding, antiviral binding, antitumor drug binding, IMMUNE SYSTEM
Exp. method : X-RAY DIFFRACTION ( 2.62 Å )
Citation :

Toll-like receptor 8 senses degradation products of single-stranded RNA.

Tanji, H.,Ohto, U.,Shibata, T.  et al.
(2015)  Nat.Struct.Mol.Biol.  22 : 109 - 115

PubMed: 25599397
DOI: 10.1038/nsmb.2943

Reaction

Chain : A, B, C, D
UniProt : Q9NR97 (TLR8_HUMAN)
Reaction : -