Brand  (β version)

PDB ID: 4PRJ

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Ligands
Code Name Style Show Link
2VU N-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide PoSSuM
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Structure summary

Code : 4PRJ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)
Release Data : 2014-07-02
Compound :
mol_id molecule chains synonym
1 Aurora kinase A A Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A
ec: 2.7.11.1
fragment: kinase domain (UNP residues 124-391)
mutation: K124A/Q154N/A203S/R251K/T287A/T288A/E336D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
Authors : Ultsch, M., Eigenbrot, C.
Keywords : protein kinase, phospho-transfer, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.

Burch, J.D.,Lau, K.,Barker, J.J.  et al.
(2014)  J.Med.Chem.  57 : 5714 - 5727

PubMed: 24918870
DOI: 10.1021/jm500550e

Reaction

Chain : A
UniProt : O14965 (AURKA_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27192185, PubMed:27837025, PubMed:28218735
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
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