PDB ID: 4PPC
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Structure summary
Code : | 4PPC PDBj RCSB PDB PDBe | ||||||||||||
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Header : | transferase/transferase inhibitor | ||||||||||||
Title : | ITK kinase domain with compound 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1-PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE) | ||||||||||||
Release Data : | 2014-06-04 | ||||||||||||
Compound : |
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Source : |
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Authors : | Eigenbrot, C., Shia, S. | ||||||||||||
Keywords : | protein kinase, phospho-transfer, transferase-transferase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.95 Å ) | ||||||||||||
Citation : |
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Pastor, R.M.,Burch, J.D.,Magnuson, S.
et al.
PubMed: 24767842 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | Q08881 (ITK_HUMAN) | ||||||||
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