ID 4PPCA STANDARD; PRT; 266 AA. DT CONVERTED FROM PDB (SEQRES) 4PPC DE Tyrosine-protein kinase ITK/TSK OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.950 CC R-Factor 0.215 FT #SUB 2 356 SER A 57 411 MET B Protein B 1 FT #SUB 2 356 SER A 68 422 TYR B Protein S 1 FT #SUB 2 356 SER A 69 423 GLY B Protein B 2 FT #SUB 2 356 SER A 70 424 VAL B Protein B 1 FT #SUB 3 357 VAL A 70 424 VAL B Protein A 3 FT #SUB 3 357 VAL A 72 426 LEU B Protein S 1 FT #SUB 4 358 ILE A 68 422 TYR B Protein S 1 FT #SUB 4 358 ILE A 69 423 GLY B Protein S 3 FT #SUB 4 358 ILE A 70 424 VAL B Protein A 7 FT #SUB 4 358 ILE A 71 425 CYS B Protein B 3 FT #SUB 6 360 PRO A 71 425 CYS B Protein A 4 FT #SUB 9 363 LEU A 36 390 ILE B Protein S 1 FT #SUB 9 363 LEU A 80 434 VAL B Protein S 2 FT #SUB 10 364 THR A 36 390 ILE B Protein B 1 FT #SUB 11 365 PHE A 36 390 ILE B Protein S 6 FT #SUB 21 375 GLY A 38 392 THR B Protein B 2 FT #SUB 21 375 GLY A 39 393 ILE B Protein B 1 FT #SUB 22 376 LEU A 36 390 ILE B Protein B 1 FT #SUB 22 376 LEU A 37 391 LYS B Protein B 2 FT #SUB 22 376 LEU A 38 392 THR B Protein A 7 FT #SUB 23 377 VAL A 36 390 ILE B Protein B 2 FT #SUB 24 378 HIS A 34 388 VAL B Protein B 1 FT #SUB 24 378 HIS A 35 389 ALA B Protein B 2 FT #SUB 24 378 HIS A 36 390 ILE B Protein A 8 FT #SUB 24 378 HIS A 38 392 THR B Protein S 1 FT #SUB 25 379 LEU A 33 387 LYS B Protein S 1 FT #SUB 25 379 LEU A 34 388 VAL B Protein B 2 FT #SUB 25 379 LEU A 83 437 PHE B Protein S 1 FT #SUB 26 380 GLY A 33 387 LYS B Protein B 2 FT #SUB 26 380 GLY A 34 388 VAL B Protein B 11 FT #SUB 26 380 GLY A 36 390 ILE B Protein B 1 FT #SUB 27 381 TYR A 32 386 ASP B Protein B 2 FT #SUB 27 381 TYR A 33 387 LYS B Protein S 4 FT #SUB 28 382 TRP A 30 384 ASN B Protein B 3 FT #SUB 28 382 TRP A 31 385 LYS B Protein B 2 FT #SUB 28 382 TRP A 32 386 ASP B Protein A 9 FT #SUB 28 382 TRP A 34 388 VAL B Protein S 1 FT #SUB 28 382 TRP A 68 422 TYR B Protein S 2 FT #SUB 29 383 LEU A 29 383 LEU B Protein S 2 FT #SUB 29 383 LEU A 30 384 ASN B Protein B 2 FT #SUB 29 383 LEU A 31 385 LYS B Protein S 1 FT #SUB 30 384 ASN A 28 382 TRP B Protein B 2 FT #SUB 30 384 ASN A 29 383 LEU B Protein B 4 FT #SUB 30 384 ASN A 30 384 ASN B Protein B 3 FT #SUB 31 385 LYS A 27 381 TYR B Protein B 2 FT #SUB 31 385 LYS A 28 382 TRP B Protein B 1 FT #SUB 31 385 LYS A 29 383 LEU B Protein A 2 FT #SUB 32 386 ASP A 26 380 GLY B Protein B 1 FT #SUB 32 386 ASP A 27 381 TYR B Protein B 2 FT #SUB 32 386 ASP A 28 382 TRP B Protein A 8 FT #SUB 33 387 LYS A 26 380 GLY B Protein B 2 FT #SUB 33 387 LYS A 27 381 TYR B Protein S 2 FT #SUB 34 388 VAL A 24 378 HIS B Protein B 1 FT #SUB 34 388 VAL A 25 379 LEU B Protein B 2 FT #SUB 34 388 VAL A 26 380 GLY B Protein A 10 FT #SUB 34 388 VAL A 27 381 TYR B Protein S 1 FT #SUB 34 388 VAL A 28 382 TRP B Protein S 3 FT #SUB 35 389 ALA A 24 378 HIS B Protein B 2 FT #SUB 36 390 ILE A 9 363 LEU B Protein S 1 FT #SUB 36 390 ILE A 11 365 PHE B Protein S 1 FT #SUB 36 390 ILE A 22 376 LEU B Protein B 1 FT #SUB 36 390 ILE A 23 377 VAL B Protein B 2 FT #SUB 36 390 ILE A 24 378 HIS B Protein B 9 FT #SUB 37 391 LYS A 21 375 GLY B Protein S 2 FT #SUB 37 391 LYS A 22 376 LEU B Protein A 3 FT #SUB 38 392 THR A 11 365 PHE B Protein S 1 FT #SUB 38 392 THR A 21 375 GLY B Protein B 3 FT #SUB 38 392 THR A 22 376 LEU B Protein A 5 FT #SUB 38 392 THR A 24 378 HIS B Protein S 1 FT #SUB 57 411 MET A 2 356 SER B Protein S 3 FT #SUB 60 414 SER A 138 492 GLU B Protein S 1 FT #SUB 62 416 PRO A 62 416 PRO B Protein S 1 FT #SUB 68 422 TYR A 2 356 SER B Protein B 1 FT #SUB 68 422 TYR A 28 382 TRP B Protein S 5 FT #SUB 69 423 GLY A 2 356 SER B Protein B 2 FT #SUB 69 423 GLY A 4 358 ILE B Protein B 3 FT #SUB 70 424 VAL A 2 356 SER B Protein B 1 FT #SUB 70 424 VAL A 3 357 VAL B Protein B 4 FT #SUB 70 424 VAL A 4 358 ILE B Protein B 7 FT #SUB 71 425 CYS A 4 358 ILE B Protein A 3 FT #SUB 71 425 CYS A 6 360 PRO B Protein S 2 FT #SUB 71 425 CYS A 9 363 LEU B Protein S 1 FT #SUB 73 427 GLU A 6 360 PRO B Protein S 2 FT #SUB 74 428 GLN A 6 360 PRO B Protein S 3 FT #SUB 80 434 VAL A 4 358 ILE B Protein S 1 FT #SUB 80 434 VAL A 9 363 LEU B Protein S 3 FT #SUB 83 437 PHE A 25 379 LEU B Protein S 1 FT #SUB 138 492 GLU A 60 414 SER B Protein S 1 FT #SUB 139 493 ASN A 58 412 LYS B Protein S 3 FT #SUB 263 617 GLU A 256 610 ARG B Protein S 5 FT #HET 13 367 GLN A 2 701 2VW B S 4 FT #HET 15 369 ILE A 2 701 2VW B S 6 FT #HET 23 377 VAL A 2 701 2VW B S 2 FT #HET 35 389 ALA A 1 701 2VW A S 5 FT #HET 37 391 LYS A 1 701 2VW A S 2 FT #HET 65 419 VAL A 1 701 2VW A S 1 FT #HET 81 435 PHE A 1 701 2VW A S 11 FT #HET 82 436 GLU A 1 701 2VW A B 5 FT #HET 83 437 PHE A 1 701 2VW A A 9 FT #HET 84 438 MET A 1 701 2VW A A 11 FT #HET 85 439 GLU A 1 701 2VW A B 3 FT #HET 86 440 HIS A 1 701 2VW A B 2 FT #HET 87 441 GLY A 1 701 2VW A B 7 FT #HET 135 489 LEU A 1 701 2VW A S 11 FT #HET 145 499 SER A 1 701 2VW A S 2 FT #HET 146 500 ASP A 1 701 2VW A A 9 FT DISORDER 1 1 FT DISORDER 19 20 FT DISORDER 40 49 FT DISORDER 148 166 FT DISORDER 266 266 CC SEQUENCE 233 AA (ATOM); CC SVIDPSELTF VQEIGSGGLV HLGYWLNKDK VAIKTIIEEA EVMMKLSHPK LVQLYGVCLE CC QAPICLVFEF MEHGCLSDYL RTQRGLFAAE TLLGMCLDVC EGMAYLEEAC VIHRDLAARN CC CLVGENQVIK VSDFPVKWAS PEVFSFSRYS SKSDVWSFGV LMWEVFSEGK IPYENRSNSE CC VVEDISTGFR LYKPRLASTH VYQIMNHCWK ERPEDRPAFS RLLRQLAEIA ESG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFI CC ATOM -SVIDPSELTFVQEIGSG--GLVHLGYWLNKDKVAIKTI----------I CC ***************** ******************* * CC SEQRES EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ATOM EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ************************************************** CC SEQRES AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMT CC ATOM AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDF--- CC *********************************************** CC SEQRES RFVLDDQETSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ATOM ----------------PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ********************************** CC SEQRES GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ATOM GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ************************************************** CC SEQRES FSRLLRQLAEIAESGL CC ATOM FSRLLRQLAEIAESG- CC *************** SQ SEQUENCE 266 AA; MW; CN; GSVIDPSELT FVQEIGSGQF GLVHLGYWLN KDKVAIKTIR EGAMSEEDFI EEAEVMMKLS HPKLVQLYGV CLEQAPICLV FEFMEHGCLS DYLRTQRGLF AAETLLGMCL DVCEGMAYLE EACVIHRDLA ARNCLVGENQ VIKVSDFGMT RFVLDDQETS STGTKFPVKW ASPEVFSFSR YSSKSDVWSF GVLMWEVFSE GKIPYENRSN SEVVEDISTG FRLYKPRLAS THVYQIMNHC WKERPEDRPA FSRLLRQLAE IAESGL // ID 4PPCB STANDARD; PRT; 266 AA. DT CONVERTED FROM PDB (SEQRES) 4PPC DE Tyrosine-protein kinase ITK/TSK OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.950 CC R-Factor 0.215 FT #SUB 2 356 SER B 57 411 MET A Protein A 3 FT #SUB 2 356 SER B 68 422 TYR A Protein S 1 FT #SUB 2 356 SER B 69 423 GLY A Protein B 2 FT #SUB 2 356 SER B 70 424 VAL A Protein B 1 FT #SUB 3 357 VAL B 70 424 VAL A Protein A 4 FT #SUB 4 358 ILE B 69 423 GLY A Protein S 3 FT #SUB 4 358 ILE B 70 424 VAL A Protein A 7 FT #SUB 4 358 ILE B 71 425 CYS A Protein B 3 FT #SUB 4 358 ILE B 80 434 VAL A Protein S 1 FT #SUB 6 360 PRO B 71 425 CYS A Protein B 2 FT #SUB 6 360 PRO B 73 427 GLU A Protein S 2 FT #SUB 6 360 PRO B 74 428 GLN A Protein S 3 FT #SUB 9 363 LEU B 36 390 ILE A Protein S 1 FT #SUB 9 363 LEU B 71 425 CYS A Protein S 1 FT #SUB 9 363 LEU B 80 434 VAL A Protein S 3 FT #SUB 11 365 PHE B 36 390 ILE A Protein S 1 FT #SUB 11 365 PHE B 38 392 THR A Protein S 1 FT #SUB 21 375 GLY B 37 391 LYS A Protein B 2 FT #SUB 21 375 GLY B 38 392 THR A Protein B 3 FT #SUB 22 376 LEU B 36 390 ILE A Protein B 1 FT #SUB 22 376 LEU B 37 391 LYS A Protein B 3 FT #SUB 22 376 LEU B 38 392 THR A Protein B 5 FT #SUB 23 377 VAL B 36 390 ILE A Protein B 2 FT #SUB 24 378 HIS B 34 388 VAL A Protein B 1 FT #SUB 24 378 HIS B 35 389 ALA A Protein B 2 FT #SUB 24 378 HIS B 36 390 ILE A Protein A 9 FT #SUB 24 378 HIS B 38 392 THR A Protein S 1 FT #SUB 25 379 LEU B 34 388 VAL A Protein B 2 FT #SUB 25 379 LEU B 83 437 PHE A Protein S 1 FT #SUB 26 380 GLY B 32 386 ASP A Protein B 1 FT #SUB 26 380 GLY B 33 387 LYS A Protein B 2 FT #SUB 26 380 GLY B 34 388 VAL A Protein B 10 FT #SUB 27 381 TYR B 31 385 LYS A Protein S 2 FT #SUB 27 381 TYR B 32 386 ASP A Protein B 2 FT #SUB 27 381 TYR B 33 387 LYS A Protein S 2 FT #SUB 27 381 TYR B 34 388 VAL A Protein B 1 FT #SUB 28 382 TRP B 30 384 ASN A Protein B 2 FT #SUB 28 382 TRP B 31 385 LYS A Protein B 1 FT #SUB 28 382 TRP B 32 386 ASP A Protein B 8 FT #SUB 28 382 TRP B 34 388 VAL A Protein A 3 FT #SUB 28 382 TRP B 68 422 TYR A Protein S 5 FT #SUB 29 383 LEU B 29 383 LEU A Protein S 2 FT #SUB 29 383 LEU B 30 384 ASN A Protein A 4 FT #SUB 29 383 LEU B 31 385 LYS A Protein S 2 FT #SUB 30 384 ASN B 28 382 TRP A Protein B 3 FT #SUB 30 384 ASN B 29 383 LEU A Protein B 2 FT #SUB 30 384 ASN B 30 384 ASN A Protein B 3 FT #SUB 31 385 LYS B 28 382 TRP A Protein B 2 FT #SUB 31 385 LYS B 29 383 LEU A Protein S 1 FT #SUB 32 386 ASP B 27 381 TYR A Protein B 2 FT #SUB 32 386 ASP B 28 382 TRP A Protein A 9 FT #SUB 33 387 LYS B 25 379 LEU A Protein S 1 FT #SUB 33 387 LYS B 26 380 GLY A Protein B 2 FT #SUB 33 387 LYS B 27 381 TYR A Protein S 4 FT #SUB 34 388 VAL B 24 378 HIS A Protein B 1 FT #SUB 34 388 VAL B 25 379 LEU A Protein B 2 FT #SUB 34 388 VAL B 26 380 GLY A Protein A 11 FT #SUB 34 388 VAL B 28 382 TRP A Protein S 1 FT #SUB 35 389 ALA B 24 378 HIS A Protein B 2 FT #SUB 36 390 ILE B 9 363 LEU A Protein S 1 FT #SUB 36 390 ILE B 10 364 THR A Protein S 1 FT #SUB 36 390 ILE B 11 365 PHE A Protein S 6 FT #SUB 36 390 ILE B 22 376 LEU A Protein B 1 FT #SUB 36 390 ILE B 23 377 VAL A Protein B 2 FT #SUB 36 390 ILE B 24 378 HIS A Protein B 8 FT #SUB 36 390 ILE B 26 380 GLY A Protein S 1 FT #SUB 37 391 LYS B 22 376 LEU A Protein B 2 FT #SUB 38 392 THR B 21 375 GLY A Protein B 2 FT #SUB 38 392 THR B 22 376 LEU A Protein A 7 FT #SUB 38 392 THR B 24 378 HIS A Protein S 1 FT #SUB 39 393 ILE B 21 375 GLY A Protein B 1 FT #SUB 57 411 MET B 2 356 SER A Protein S 1 FT #SUB 58 412 LYS B 139 493 ASN A Protein B 3 FT #SUB 60 414 SER B 138 492 GLU A Protein S 1 FT #SUB 62 416 PRO B 62 416 PRO A Protein S 1 FT #SUB 68 422 TYR B 2 356 SER A Protein B 1 FT #SUB 68 422 TYR B 4 358 ILE A Protein B 1 FT #SUB 68 422 TYR B 28 382 TRP A Protein S 2 FT #SUB 69 423 GLY B 2 356 SER A Protein B 2 FT #SUB 69 423 GLY B 4 358 ILE A Protein B 3 FT #SUB 70 424 VAL B 2 356 SER A Protein B 1 FT #SUB 70 424 VAL B 3 357 VAL A Protein B 3 FT #SUB 70 424 VAL B 4 358 ILE A Protein B 7 FT #SUB 71 425 CYS B 4 358 ILE A Protein A 3 FT #SUB 71 425 CYS B 6 360 PRO A Protein S 4 FT #SUB 72 426 LEU B 3 357 VAL A Protein S 1 FT #SUB 80 434 VAL B 9 363 LEU A Protein S 2 FT #SUB 83 437 PHE B 25 379 LEU A Protein S 1 FT #SUB 138 492 GLU B 60 414 SER A Protein S 1 FT #SUB 256 610 ARG B 263 617 GLU A Protein S 5 FT #HET 13 367 GLN B 1 701 2VW A S 6 FT #HET 15 369 ILE B 1 701 2VW A S 8 FT #HET 23 377 VAL B 1 701 2VW A S 2 FT #HET 35 389 ALA B 2 701 2VW B S 5 FT #HET 37 391 LYS B 2 701 2VW B S 6 FT #HET 65 419 VAL B 2 701 2VW B S 1 FT #HET 81 435 PHE B 2 701 2VW B S 11 FT #HET 82 436 GLU B 2 701 2VW B B 4 FT #HET 83 437 PHE B 2 701 2VW B A 10 FT #HET 84 438 MET B 2 701 2VW B A 12 FT #HET 85 439 GLU B 2 701 2VW B B 3 FT #HET 86 440 HIS B 2 701 2VW B B 1 FT #HET 87 441 GLY B 2 701 2VW B B 9 FT #HET 91 445 ASP B 2 701 2VW B S 1 FT #HET 135 489 LEU B 2 701 2VW B S 7 FT #HET 145 499 SER B 2 701 2VW B S 2 FT #HET 146 500 ASP B 2 701 2VW B A 4 FT DISORDER 1 1 FT DISORDER 19 20 FT DISORDER 40 49 FT DISORDER 73 74 FT DISORDER 148 166 FT DISORDER 266 266 CC SEQUENCE 231 AA (ATOM); CC SVIDPSELTF VQEIGSGGLV HLGYWLNKDK VAIKTIIEEA EVMMKLSHPK LVQLYGVCLA CC PICLVFEFME HGCLSDYLRT QRGLFAAETL LGMCLDVCEG MAYLEEACVI HRDLAARNCL CC VGENQVIKVS DFPVKWASPE VFSFSRYSSK SDVWSFGVLM WEVFSEGKIP YENRSNSEVV CC EDISTGFRLY KPRLASTHVY QIMNHCWKER PEDRPAFSRL LRQLAEIAES G CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES GSVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFI CC ATOM -SVIDPSELTFVQEIGSG--GLVHLGYWLNKDKVAIKTI----------I CC ***************** ******************* * CC SEQRES EEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLF CC ATOM EEAEVMMKLSHPKLVQLYGVCL--APICLVFEFMEHGCLSDYLRTQRGLF CC ********************** ************************** CC SEQRES AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMT CC ATOM AAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDF--- CC *********************************************** CC SEQRES RFVLDDQETSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ATOM ----------------PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSE CC ********************************** CC SEQRES GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ATOM GKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPA CC ************************************************** CC SEQRES FSRLLRQLAEIAESGL CC ATOM FSRLLRQLAEIAESG- CC *************** SQ SEQUENCE 266 AA; MW; CN; GSVIDPSELT FVQEIGSGQF GLVHLGYWLN KDKVAIKTIR EGAMSEEDFI EEAEVMMKLS HPKLVQLYGV CLEQAPICLV FEFMEHGCLS DYLRTQRGLF AAETLLGMCL DVCEGMAYLE EACVIHRDLA ARNCLVGENQ VIKVSDFGMT RFVLDDQETS STGTKFPVKW ASPEVFSFSR YSSKSDVWSF GVLMWEVFSE GKIPYENRSN SEVVEDISTG FRLYKPRLAS THVYQIMNHC WKERPEDRPA FSRLLRQLAE IAESGL //