Het-PDB Navi2 (PDB: 4HVD)

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Ligands
Code	Name		Style	Show	Link
933	2-cyclopropyl-N-[(2s)-3,3-dimethylbutan-2-yl]-5h-pyrrolo[2,3-B]pyrazine-7-carboxamide				PoSSuM
PHU	1-phenylurea				PoSSuM

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Download interaction data: 4HVD

Code :

4HVD PDBj RCSB PDB PDBe

Header :

Transferase/Transferase Inhibitor

Title :

JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-B]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide

Release Data :

2013-01-16

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein kinase JAK3	A	Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK
	ec: 2.7.10.2 fragment: RESIDUES 811-1124 mutation: C1040S, C1048S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: JAK3

Authors :

Kuglstatter, A., Shao, A.

Keywords :

Kinase-Inhibitor Complex, Transferase-Transferase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.85 Å )

Citation :

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.

Soth, M.,Hermann, J.C.,Yee, C. et al.
(2013) J.Med.Chem. 56 : 345 - 356

Chain :

UniProt :

P52333 (JAK3_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 4HVD