Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0XV (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone
GOL Glycerol
HEM Protoporphyrin ix containing Fe
Code : 4GQS
Header : OXIDOREDUCTASE
Title : Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
Release Data : 2012-11-14
Compound :
mol_id molecule chains synonym
1 Cytochrome P450 2C19 A,B,C,D (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase
ec: 1.14.13.-, 1.14.13.80, 1.14.13.48, 1.14.13.49
fragment: CATALYTIC DOMAIN (UNP Residues 21-490)
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:668369)
strain: ALLELIC VARIANT 1B
gene: CYP2C19
expression_system_strain: DH5alpha
expression_system_vector_type: PLASMID
expression_system_plasmid: PCW0RI
Authors : Reynald, R.L., Sansen, S., Stout, C.D., Johnson, E.F.
Keywords : monooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein
Exp. method : X-RAY DIFFRACTION ( 2.87 Å )
Citation :

Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.

Reynald, R.L.,Sansen, S.,Stout, C.D.  et al.
(2012)  J.Biol.Chem.  287 : 44581 - 44591

PubMed: 23118231
DOI: 10.1074/jbc.M112.424895

Chain : A, B, C, D
UniProt : P33261 (CP2CJ_HUMAN)
Reaction : (+)-(R)-limonene + NADPH + O(2) = (+)-trans- carveol + NADP(+) + H(2)O.
(-)-(S)-limonene + NADPH + O(2) = (-)-trans- carveol + NADP(+) + H(2)O.
(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.