PDB ID: 4FSL
Hetero Atom Contents
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0VB | N-{N-[4-(acetylamino)-3-chloro-5-methylbenzyl]carbamimidoyl}-3-(4-methoxyphenyl)-5-methyl-1,2-thiazole-4-carboxamide | PoSSuM | |||
IOD | Iodide ion | PoSSuM |
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Download interaction data: 4FSL
Structure summary
Code : | 4FSL PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/INHIBITOR | ||||||||||||
Title : | Crystal structure of beta-site app-cleaving enzyme 1 (BACE-DB-MUT) complex with N-(N-(4- acetamido-3-chloro-5-methylbenzyl)carbamimidoyl)-3-(4- methoxyphenyl)-5-methyl-4-isothiazolecarboxamide | ||||||||||||
Release Data : | 2012-10-10 | ||||||||||||
Compound : |
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Authors : | Muckelbauer, J.K. | ||||||||||||
Keywords : | ALZHEIMER'S DISEASE, BETA-SECRETASE, MEMAPSIN 2, BASE, ASPARTIC PROTEASE, HYDROLASE-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.5000 Å ) | ||||||||||||
Citation : |
Acyl Guanidine Inhibitors of beta-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Gerritz, S.W.,Zhai, W.,Shi, S.
et al.
PubMed: 23030502 |
Reaction
Chain : | A, B, D, E | ||||||||
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UniProt : | P56817 (BACE1_HUMAN) | ||||||||
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