ID 4FSLA STANDARD; PRT; 412 AA. DT CONVERTED FROM PDB (SEQRES) 4FSL DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.227 FT #SUB 224 253 ARG A 384 413 PHE B Protein S 10 FT #SUB 226 255 GLU A 384 413 PHE B Protein S 1 FT #SUB 228 257 ASN A 228 257 ASN B Protein A 8 FT #SUB 229 258 GLY A 297 326 ASN B Protein B 4 FT #SUB 230 259 GLN A 270 299 ALA B Protein S 2 FT #SUB 230 259 GLN A 297 326 ASN B Protein A 7 FT #SUB 230 259 GLN A 298 327 ILE B Protein S 4 FT #SUB 231 260 ASP A 297 326 ASN B Protein A 5 FT #SUB 233 262 LYS A 297 326 ASN B Protein S 1 FT #SUB 270 299 ALA A 230 259 GLN B Protein B 2 FT #SUB 273 302 THR A 230 259 GLN B Protein S 2 FT #SUB 297 326 ASN A 229 258 GLY B Protein A 3 FT #SUB 297 326 ASN A 230 259 GLN B Protein A 6 FT #SUB 297 326 ASN A 231 260 ASP B Protein S 5 FT #SUB 297 326 ASN A 233 262 LYS B Protein S 1 FT #SUB 298 327 ILE A 230 259 GLN B Protein B 1 FT #SUB 305 334 TYR A 384 413 PHE B Protein S 1 FT #SUB 316 345 ARG A 384 413 PHE B Protein S 4 FT #SUB 383 412 GLU A 393 422 PHE B Protein A 5 FT #SUB 383 412 GLU A 394 423 VAL B Protein S 8 FT #SUB 384 413 PHE A 224 253 ARG B Protein S 13 FT #SUB 384 413 PHE A 305 334 TYR B Protein S 5 FT #SUB 384 413 PHE A 316 345 ARG B Protein B 5 FT #SUB 393 422 PHE A 383 412 GLU B Protein S 2 FT #SUB 393 422 PHE A 384 413 PHE B Protein S 2 FT #HET 49 78 LEU A 1 501 0VB A S 1 FT #HET 51 80 ASP A 1 501 0VB A S 7 FT #HET 53 82 GLY A 1 501 0VB A B 5 FT #HET 54 83 SER A 1 501 0VB A B 1 FT #HET 86 115 VAL A 3 503 IOD A A 2 FT #HET 87 116 TYR A 3 503 IOD A B 2 FT #HET 90 119 TYR A 1 501 0VB A S 11 FT #HET 91 120 THR A 1 501 0VB A S 1 FT #HET 92 121 GLN A 1 501 0VB A S 17 FT #HET 93 122 GLY A 1 501 0VB A B 3 FT #HET 123 152 GLU A 4 504 IOD A B 1 FT #HET 126 155 LYS A 1 501 0VB A B 3 FT #HET 127 156 PHE A 1 501 0VB A A 10 FT #HET 129 158 ILE A 1 501 0VB A S 3 FT #HET 134 163 TRP A 1 501 0VB A S 2 FT #HET 148 177 PRO A 3 503 IOD A A 2 FT #HET 217 246 TYR A 1 501 0VB A S 3 FT #HET 245 274 ILE A 1 501 0VB A S 2 FT #HET 247 276 ASP A 1 501 0VB A S 13 FT #HET 249 278 GLY A 1 501 0VB A B 3 FT #HET 250 279 THR A 1 501 0VB A S 6 FT #HET 250 279 THR A 2 502 IOD A S 1 FT #HET 252 281 ASN A 2 502 IOD A A 3 FT #HET 254 283 ARG A 1 501 0VB A S 14 FT #HET 254 283 ARG A 2 502 IOD A S 1 FT #HET 348 377 THR A 1 501 0VB A S 2 FT #HET 351 380 VAL A 1 501 0VB A S 2 FT DISORDER 1 17 FT DISORDER 405 412 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES LPRETDEEPEEPGKKGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ATOM -----------------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ********************************* CC SEQRES DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ATOM DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ************************************************** CC SEQRES TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ATOM TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ************************************************** CC SEQRES SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ATOM SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ************************************************** CC SEQRES SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ATOM SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ************************************************** CC SEQRES TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ATOM TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ************************************************** CC SEQRES VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ATOM VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ************************************************** CC SEQRES VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ATOM VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ************************************************** CC SEQRES CGYNIPQTDEST CC ATOM CGYN-------- CC **** SQ SEQUENCE 412 AA; MW; CN; LPRETDEEPE EPGKKGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNIPQTDE ST // ID 4FSLB STANDARD; PRT; 412 AA. DT CONVERTED FROM PDB (SEQRES) 4FSL DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.227 FT #SUB 224 253 ARG B 384 413 PHE A Protein S 13 FT #SUB 228 257 ASN B 228 257 ASN A Protein A 8 FT #SUB 229 258 GLY B 297 326 ASN A Protein B 3 FT #SUB 230 259 GLN B 270 299 ALA A Protein S 2 FT #SUB 230 259 GLN B 273 302 THR A Protein S 2 FT #SUB 230 259 GLN B 297 326 ASN A Protein A 6 FT #SUB 230 259 GLN B 298 327 ILE A Protein S 1 FT #SUB 231 260 ASP B 297 326 ASN A Protein A 5 FT #SUB 233 262 LYS B 297 326 ASN A Protein S 1 FT #SUB 270 299 ALA B 230 259 GLN A Protein B 2 FT #SUB 297 326 ASN B 229 258 GLY A Protein A 4 FT #SUB 297 326 ASN B 230 259 GLN A Protein A 7 FT #SUB 297 326 ASN B 231 260 ASP A Protein S 5 FT #SUB 297 326 ASN B 233 262 LYS A Protein S 1 FT #SUB 298 327 ILE B 230 259 GLN A Protein B 4 FT #SUB 305 334 TYR B 384 413 PHE A Protein S 5 FT #SUB 316 345 ARG B 384 413 PHE A Protein S 5 FT #SUB 383 412 GLU B 393 422 PHE A Protein B 2 FT #SUB 384 413 PHE B 224 253 ARG A Protein S 10 FT #SUB 384 413 PHE B 226 255 GLU A Protein S 1 FT #SUB 384 413 PHE B 305 334 TYR A Protein S 1 FT #SUB 384 413 PHE B 316 345 ARG A Protein B 4 FT #SUB 384 413 PHE B 393 422 PHE A Protein A 2 FT #SUB 393 422 PHE B 383 412 GLU A Protein A 5 FT #SUB 394 423 VAL B 383 412 GLU A Protein A 8 FT #SUB 164 193 HIS B 288 317 CYS D Protein S 3 FT #SUB 164 193 HIS B 290 319 GLN D Protein S 4 FT #SUB 164 193 HIS B 336 365 ASP D Protein S 5 FT #HET 49 78 LEU B 5 501 0VB B S 2 FT #HET 51 80 ASP B 5 501 0VB B S 7 FT #HET 53 82 GLY B 5 501 0VB B B 8 FT #HET 54 83 SER B 5 501 0VB B A 3 FT #HET 86 115 VAL B 7 503 IOD B B 2 FT #HET 87 116 TYR B 7 503 IOD B B 2 FT #HET 90 119 TYR B 5 501 0VB B S 7 FT #HET 91 120 THR B 5 501 0VB B S 1 FT #HET 92 121 GLN B 5 501 0VB B S 20 FT #HET 93 122 GLY B 5 501 0VB B B 3 FT #HET 94 123 LYS B 8 504 IOD B B 1 FT #HET 123 152 GLU B 8 504 IOD B B 2 FT #HET 124 153 SER B 8 504 IOD B B 3 FT #HET 126 155 LYS B 5 501 0VB B B 3 FT #HET 127 156 PHE B 5 501 0VB B A 11 FT #HET 129 158 ILE B 5 501 0VB B S 2 FT #HET 134 163 TRP B 5 501 0VB B S 2 FT #HET 148 177 PRO B 7 503 IOD B A 2 FT #HET 217 246 TYR B 5 501 0VB B S 2 FT #HET 245 274 ILE B 5 501 0VB B S 2 FT #HET 247 276 ASP B 5 501 0VB B S 12 FT #HET 249 278 GLY B 5 501 0VB B B 1 FT #HET 250 279 THR B 5 501 0VB B S 5 FT #HET 250 279 THR B 6 502 IOD B S 1 FT #HET 252 281 ASN B 6 502 IOD B A 3 FT #HET 254 283 ARG B 5 501 0VB B S 15 FT #HET 254 283 ARG B 6 502 IOD B S 1 FT #HET 348 377 THR B 5 501 0VB B S 4 FT #HET 351 380 VAL B 5 501 0VB B S 2 FT DISORDER 1 17 FT DISORDER 405 412 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES LPRETDEEPEEPGKKGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ATOM -----------------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ********************************* CC SEQRES DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ATOM DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ************************************************** CC SEQRES TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ATOM TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ************************************************** CC SEQRES SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ATOM SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ************************************************** CC SEQRES SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ATOM SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ************************************************** CC SEQRES TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ATOM TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ************************************************** CC SEQRES VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ATOM VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ************************************************** CC SEQRES VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ATOM VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ************************************************** CC SEQRES CGYNIPQTDEST CC ATOM CGYN-------- CC **** SQ SEQUENCE 412 AA; MW; CN; LPRETDEEPE EPGKKGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNIPQTDE ST // ID 4FSLD STANDARD; PRT; 412 AA. DT CONVERTED FROM PDB (SEQRES) 4FSL DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.227 FT #SUB 288 317 CYS D 164 193 HIS B Protein B 3 FT #SUB 290 319 GLN D 164 193 HIS B Protein S 4 FT #SUB 336 365 ASP D 164 193 HIS B Protein S 5 FT #SUB 224 253 ARG D 384 413 PHE E Protein S 6 FT #SUB 228 257 ASN D 228 257 ASN E Protein A 8 FT #SUB 229 258 GLY D 297 326 ASN E Protein B 3 FT #SUB 230 259 GLN D 270 299 ALA E Protein S 3 FT #SUB 230 259 GLN D 273 302 THR E Protein S 2 FT #SUB 230 259 GLN D 297 326 ASN E Protein A 7 FT #SUB 230 259 GLN D 298 327 ILE E Protein S 5 FT #SUB 231 260 ASP D 297 326 ASN E Protein A 4 FT #SUB 270 299 ALA D 230 259 GLN E Protein B 4 FT #SUB 297 326 ASN D 229 258 GLY E Protein A 3 FT #SUB 297 326 ASN D 230 259 GLN E Protein A 5 FT #SUB 297 326 ASN D 231 260 ASP E Protein S 5 FT #SUB 297 326 ASN D 233 262 LYS E Protein S 3 FT #SUB 298 327 ILE D 230 259 GLN E Protein A 2 FT #SUB 298 327 ILE D 233 262 LYS E Protein S 1 FT #SUB 305 334 TYR D 384 413 PHE E Protein S 1 FT #SUB 316 345 ARG D 384 413 PHE E Protein S 4 FT #SUB 383 412 GLU D 393 422 PHE E Protein B 2 FT #SUB 383 412 GLU D 394 423 VAL E Protein S 5 FT #SUB 384 413 PHE D 224 253 ARG E Protein S 9 FT #SUB 384 413 PHE D 305 334 TYR E Protein S 1 FT #SUB 384 413 PHE D 316 345 ARG E Protein B 4 FT #SUB 384 413 PHE D 393 422 PHE E Protein A 2 FT #SUB 393 422 PHE D 383 412 GLU E Protein S 2 FT #SUB 394 423 VAL D 383 412 GLU E Protein A 4 FT #HET 49 78 LEU D 9 501 0VB D S 1 FT #HET 51 80 ASP D 9 501 0VB D S 7 FT #HET 53 82 GLY D 9 501 0VB D B 3 FT #HET 86 115 VAL D 11 503 IOD D B 1 FT #HET 87 116 TYR D 11 503 IOD D B 2 FT #HET 90 119 TYR D 9 501 0VB D S 11 FT #HET 91 120 THR D 9 501 0VB D S 2 FT #HET 92 121 GLN D 9 501 0VB D S 19 FT #HET 93 122 GLY D 9 501 0VB D B 3 FT #HET 96 125 GLU D 12 504 IOD D S 1 FT #HET 123 152 GLU D 12 504 IOD D B 1 FT #HET 124 153 SER D 12 504 IOD D B 1 FT #HET 126 155 LYS D 9 501 0VB D B 3 FT #HET 127 156 PHE D 9 501 0VB D A 11 FT #HET 129 158 ILE D 9 501 0VB D S 3 FT #HET 134 163 TRP D 9 501 0VB D S 2 FT #HET 148 177 PRO D 11 503 IOD D A 2 FT #HET 217 246 TYR D 9 501 0VB D S 3 FT #HET 245 274 ILE D 9 501 0VB D S 2 FT #HET 247 276 ASP D 9 501 0VB D S 13 FT #HET 249 278 GLY D 9 501 0VB D B 4 FT #HET 250 279 THR D 9 501 0VB D S 4 FT #HET 250 279 THR D 10 502 IOD D S 1 FT #HET 252 281 ASN D 10 502 IOD D A 3 FT #HET 254 283 ARG D 9 501 0VB D S 17 FT #HET 254 283 ARG D 10 502 IOD D S 1 FT #HET 348 377 THR D 9 501 0VB D S 4 FT #HET 351 380 VAL D 9 501 0VB D S 2 FT DISORDER 1 17 FT DISORDER 405 412 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES LPRETDEEPEEPGKKGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ATOM -----------------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ********************************* CC SEQRES DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ATOM DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ************************************************** CC SEQRES TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ATOM TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ************************************************** CC SEQRES SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ATOM SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ************************************************** CC SEQRES SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ATOM SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ************************************************** CC SEQRES TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ATOM TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ************************************************** CC SEQRES VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ATOM VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ************************************************** CC SEQRES VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ATOM VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ************************************************** CC SEQRES CGYNIPQTDEST CC ATOM CGYN-------- CC **** SQ SEQUENCE 412 AA; MW; CN; LPRETDEEPE EPGKKGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNIPQTDE ST // ID 4FSLE STANDARD; PRT; 412 AA. DT CONVERTED FROM PDB (SEQRES) 4FSL DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.500 CC R-Factor 0.227 FT #SUB 224 253 ARG E 384 413 PHE D Protein S 9 FT #SUB 228 257 ASN E 228 257 ASN D Protein A 8 FT #SUB 229 258 GLY E 297 326 ASN D Protein B 3 FT #SUB 230 259 GLN E 270 299 ALA D Protein S 4 FT #SUB 230 259 GLN E 297 326 ASN D Protein A 5 FT #SUB 230 259 GLN E 298 327 ILE D Protein S 2 FT #SUB 231 260 ASP E 297 326 ASN D Protein A 5 FT #SUB 233 262 LYS E 297 326 ASN D Protein S 3 FT #SUB 233 262 LYS E 298 327 ILE D Protein S 1 FT #SUB 270 299 ALA E 230 259 GLN D Protein B 3 FT #SUB 273 302 THR E 230 259 GLN D Protein S 2 FT #SUB 297 326 ASN E 229 258 GLY D Protein A 3 FT #SUB 297 326 ASN E 230 259 GLN D Protein A 7 FT #SUB 297 326 ASN E 231 260 ASP D Protein S 4 FT #SUB 298 327 ILE E 230 259 GLN D Protein A 5 FT #SUB 305 334 TYR E 384 413 PHE D Protein S 1 FT #SUB 316 345 ARG E 384 413 PHE D Protein S 4 FT #SUB 383 412 GLU E 393 422 PHE D Protein B 2 FT #SUB 383 412 GLU E 394 423 VAL D Protein S 4 FT #SUB 384 413 PHE E 224 253 ARG D Protein S 6 FT #SUB 384 413 PHE E 305 334 TYR D Protein S 1 FT #SUB 384 413 PHE E 316 345 ARG D Protein B 4 FT #SUB 393 422 PHE E 383 412 GLU D Protein S 2 FT #SUB 393 422 PHE E 384 413 PHE D Protein S 2 FT #SUB 394 423 VAL E 383 412 GLU D Protein B 5 FT #HET 49 78 LEU E 13 501 0VB E S 2 FT #HET 51 80 ASP E 13 501 0VB E S 7 FT #HET 53 82 GLY E 13 501 0VB E B 2 FT #HET 86 115 VAL E 15 503 IOD E B 1 FT #HET 87 116 TYR E 15 503 IOD E B 2 FT #HET 90 119 TYR E 13 501 0VB E S 9 FT #HET 92 121 GLN E 13 501 0VB E S 18 FT #HET 93 122 GLY E 13 501 0VB E B 3 FT #HET 94 123 LYS E 16 504 IOD E S 1 FT #HET 123 152 GLU E 16 504 IOD E B 1 FT #HET 126 155 LYS E 13 501 0VB E B 3 FT #HET 127 156 PHE E 13 501 0VB E A 10 FT #HET 129 158 ILE E 13 501 0VB E S 4 FT #HET 134 163 TRP E 13 501 0VB E S 2 FT #HET 148 177 PRO E 15 503 IOD E A 2 FT #HET 217 246 TYR E 13 501 0VB E S 2 FT #HET 245 274 ILE E 13 501 0VB E S 2 FT #HET 247 276 ASP E 13 501 0VB E S 13 FT #HET 249 278 GLY E 13 501 0VB E B 6 FT #HET 250 279 THR E 13 501 0VB E S 6 FT #HET 250 279 THR E 14 502 IOD E S 1 FT #HET 252 281 ASN E 14 502 IOD E A 4 FT #HET 254 283 ARG E 13 501 0VB E S 15 FT #HET 254 283 ARG E 14 502 IOD E S 1 FT #HET 348 377 THR E 13 501 0VB E S 3 FT #HET 351 380 VAL E 13 501 0VB E S 2 FT DISORDER 1 17 FT DISORDER 405 412 CC SEQUENCE 387 AA (ATOM); CC FVEMVDNLRG KSGQGYYVEM TVGSPPQTLN ILVDTGSSNF AVGAAPHPFL HRYYQRQLSS CC TYRDLRKGVY VPYTQGKWEG ELGTDLVSIP HGPNVTVRAN IAAITESDKF FINGSNWEGI CC LGLAYAEIAR PDDSLEPFFD SLVKQTHVPN LFSLQLCGAG FPLNQSEVLA SVGGSMIIGG CC IDHSLYTGSL WYTPIRREWY YEVIIVRVEI NGQDLKMDCK EYNYDKSIVD SGTTNLRLPK CC KVFEAAVKSI KAASSTEKFP DGFWLGEQLV CWQAGTTPWN IFPVISLYLM GEVTNQSFRI CC TILPQQYLRP VEDVATSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES LPRETDEEPEEPGKKGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ATOM -----------------FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILV CC ********************************* CC SEQRES DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ATOM DTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELG CC ************************************************** CC SEQRES TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ATOM TDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDD CC ************************************************** CC SEQRES SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ATOM SLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDH CC ************************************************** CC SEQRES SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ATOM SLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGT CC ************************************************** CC SEQRES TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ATOM TNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFP CC ************************************************** CC SEQRES VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ATOM VISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGT CC ************************************************** CC SEQRES VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ATOM VMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMED CC ************************************************** CC SEQRES CGYNIPQTDEST CC ATOM CGYN-------- CC **** SQ SEQUENCE 412 AA; MW; CN; LPRETDEEPE EPGKKGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNIPQTDE ST //