PDB ID: 4FK6
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0UJ | N-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridin-2-yl}methyl)methanesulfonamide | PoSSuM |
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PTR | O-phosphotyrosine |
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Download interaction data: 4FK6
Structure summary
Code : | 4FK6 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | JAK1 kinase (JH1 domain) in complex with compound 72 | ||||||||||||
Release Data : | 2012-11-07 | ||||||||||||
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Authors : | Eigenbrot, C., Steffek, M. | ||||||||||||
Keywords : | protein kinase, phospho transfer, phospho tyrosine, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.20 Å ) | ||||||||||||
Citation : |
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Labadie, S.,Dragovich, P.S.,Barrett, K.
et al.
PubMed: 23107482 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P23458 (JAK1_HUMAN) | ||||||||
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