ID	4FK6A	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4FK6
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.200
CC	R-Factor	0.211
FT	#SUB	185	1037 	VAL	A	251	1103 	ARG	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	244	1096 	HIS	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	251	1103 	ARG	B	Protein	B	1
FT	#SUB	188	1040 	ASP	A	244	1096 	HIS	B	Protein	S	8
FT	#SUB	188	1040 	ASP	A	247	1099 	MET	B	Protein	A	8
FT	#SUB	188	1040 	ASP	A	251	1103 	ARG	B	Protein	S	7
FT	#SUB	189	1041 	ARG	A	243	1095 	THR	B	Protein	S	5
FT	#SUB	189	1041 	ARG	A	244	1096 	HIS	B	Protein	B	1
FT	#SUB	189	1041 	ARG	A	245	1097 	GLY	B	Protein	S	2
FT	#SUB	189	1041 	ARG	A	246	1098 	GLN	B	Protein	B	1
FT	#SUB	191	1043 	SER	A	246	1098 	GLN	B	Protein	B	1
FT	#SUB	193	1045 	VAL	A	246	1098 	GLN	B	Protein	S	3
FT	#SUB	193	1045 	VAL	A	247	1099 	MET	B	Protein	S	1
FT	#SUB	201	1053 	LEU	A	247	1099 	MET	B	Protein	B	1
FT	#SUB	201	1053 	LEU	A	250	1102 	THR	B	Protein	B	2
FT	#SUB	202	1054 	MET	A	250	1102 	THR	B	Protein	B	1
FT	#SUB	202	1054 	MET	A	254	1106 	ASN	B	Protein	B	4
FT	#SUB	204	1056 	SER	A	251	1103 	ARG	B	Protein	S	3
FT	#SUB	243	1095 	THR	A	189	1041 	ARG	B	Protein	B	4
FT	#SUB	244	1096 	HIS	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	244	1096 	HIS	A	188	1040 	ASP	B	Protein	A	8
FT	#SUB	244	1096 	HIS	A	189	1041 	ARG	B	Protein	B	1
FT	#SUB	245	1097 	GLY	A	189	1041 	ARG	B	Protein	B	1
FT	#SUB	246	1098 	GLN	A	189	1041 	ARG	B	Protein	S	3
FT	#SUB	246	1098 	GLN	A	191	1043 	SER	B	Protein	S	2
FT	#SUB	246	1098 	GLN	A	193	1045 	VAL	B	Protein	S	3
FT	#SUB	247	1099 	MET	A	188	1040 	ASP	B	Protein	S	8
FT	#SUB	247	1099 	MET	A	193	1045 	VAL	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	201	1053 	LEU	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	247	1099 	MET	B	Protein	S	2
FT	#SUB	249	1101 	VAL	A	250	1102 	THR	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	201	1053 	LEU	B	Protein	S	2
FT	#SUB	250	1102 	THR	A	202	1054 	MET	B	Protein	S	2
FT	#SUB	250	1102 	THR	A	249	1101 	VAL	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	185	1037 	VAL	B	Protein	S	2
FT	#SUB	251	1103 	ARG	A	186	1038 	LYS	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	188	1040 	ASP	B	Protein	S	7
FT	#SUB	251	1103 	ARG	A	204	1056 	SER	B	Protein	S	2
FT	#SUB	254	1106 	ASN	A	202	1054 	MET	B	Protein	S	4
FT	#HET	27	 879 	ARG	A	1	1201 	0UJ	A	S	5
FT	#HET	29	 881 	LEU	A	1	1201 	0UJ	A	A	12
FT	#HET	37	 889 	VAL	A	1	1201 	0UJ	A	S	3
FT	#HET	54	 906 	ALA	A	1	1201 	0UJ	A	S	3
FT	#HET	104	 956 	MET	A	1	1201 	0UJ	A	S	2
FT	#HET	105	 957 	GLU	A	1	1201 	0UJ	A	B	3
FT	#HET	106	 958 	PHE	A	1	1201 	0UJ	A	A	5
FT	#HET	107	 959 	LEU	A	1	1201 	0UJ	A	B	6
FT	#HET	110	 962 	GLY	A	1	1201 	0UJ	A	B	1
FT	#HET	111	 963 	SER	A	1	1201 	0UJ	A	B	1
FT	#HET	114	 966 	GLU	A	1	1201 	0UJ	A	S	13
FT	#HET	155	1007 	ARG	A	1	1201 	0UJ	A	B	2
FT	#HET	156	1008 	ASN	A	1	1201 	0UJ	A	S	2
FT	#HET	158	1010 	LEU	A	1	1201 	0UJ	A	S	14
FT	#HET	168	1020 	GLY	A	1	1201 	0UJ	A	B	5
FT	#HET	169	1021 	ASP	A	1	1201 	0UJ	A	S	4
FT	DISORDER	1	10
FT	DISORDER	32	33
FT	DISORDER	62	64
CC	SEQUENCE	287 AA (ATOM);
CC	TEVDPTHFEK RFLKRIRDLG EFGKVELCRY DPEGDNTGEQ VAVKSLKPEN HIADLKKEIE
CC	ILRNLYHENI VKYKGICTED GGNGIKLIME FLPSGSLKEY LPKNKNKINL KQQLKYAVQI
CC	CKGMDYLGSR QYVHRDLAAR NVLVESEHQV KIGDFGLTKA IETDKEYYTV KDDRDSPVFW
CC	YAPECLMQSK FYIASDVWSF GVTLHELLTY CDSDSSPMAL FLKMIGPTHG QMTVTRLVNT
CC	LKEGKRLPCP PNCPDEVYQL MRKCWEFQPS NRTSFQNLIE GFEALLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   ----------TEVDPTHFEKRFLKRIRDLGE--FGKVELCRYDPEGDNTG
CC	                 *********************  *****************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKPE---NHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	       ***********   ************************************
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4FK6B	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4FK6
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.200
CC	R-Factor	0.211
FT	#SUB	185	1037 	VAL	B	251	1103 	ARG	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	244	1096 	HIS	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	251	1103 	ARG	A	Protein	B	1
FT	#SUB	188	1040 	ASP	B	244	1096 	HIS	A	Protein	S	8
FT	#SUB	188	1040 	ASP	B	247	1099 	MET	A	Protein	A	8
FT	#SUB	188	1040 	ASP	B	251	1103 	ARG	A	Protein	S	7
FT	#SUB	189	1041 	ARG	B	243	1095 	THR	A	Protein	S	4
FT	#SUB	189	1041 	ARG	B	244	1096 	HIS	A	Protein	B	1
FT	#SUB	189	1041 	ARG	B	245	1097 	GLY	A	Protein	S	1
FT	#SUB	189	1041 	ARG	B	246	1098 	GLN	A	Protein	B	3
FT	#SUB	191	1043 	SER	B	246	1098 	GLN	A	Protein	B	2
FT	#SUB	193	1045 	VAL	B	246	1098 	GLN	A	Protein	S	3
FT	#SUB	193	1045 	VAL	B	247	1099 	MET	A	Protein	S	1
FT	#SUB	201	1053 	LEU	B	247	1099 	MET	A	Protein	B	1
FT	#SUB	201	1053 	LEU	B	250	1102 	THR	A	Protein	B	2
FT	#SUB	202	1054 	MET	B	250	1102 	THR	A	Protein	B	2
FT	#SUB	202	1054 	MET	B	254	1106 	ASN	A	Protein	B	4
FT	#SUB	204	1056 	SER	B	251	1103 	ARG	A	Protein	S	2
FT	#SUB	243	1095 	THR	B	189	1041 	ARG	A	Protein	B	5
FT	#SUB	244	1096 	HIS	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	244	1096 	HIS	B	188	1040 	ASP	A	Protein	A	8
FT	#SUB	244	1096 	HIS	B	189	1041 	ARG	A	Protein	B	1
FT	#SUB	245	1097 	GLY	B	189	1041 	ARG	A	Protein	B	2
FT	#SUB	246	1098 	GLN	B	189	1041 	ARG	A	Protein	S	1
FT	#SUB	246	1098 	GLN	B	191	1043 	SER	A	Protein	S	1
FT	#SUB	246	1098 	GLN	B	193	1045 	VAL	A	Protein	S	3
FT	#SUB	247	1099 	MET	B	188	1040 	ASP	A	Protein	S	8
FT	#SUB	247	1099 	MET	B	193	1045 	VAL	A	Protein	S	1
FT	#SUB	247	1099 	MET	B	201	1053 	LEU	A	Protein	S	1
FT	#SUB	247	1099 	MET	B	249	1101 	VAL	A	Protein	S	2
FT	#SUB	249	1101 	VAL	B	250	1102 	THR	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	201	1053 	LEU	A	Protein	S	2
FT	#SUB	250	1102 	THR	B	202	1054 	MET	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	249	1101 	VAL	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	185	1037 	VAL	A	Protein	S	2
FT	#SUB	251	1103 	ARG	B	186	1038 	LYS	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	188	1040 	ASP	A	Protein	S	7
FT	#SUB	251	1103 	ARG	B	204	1056 	SER	A	Protein	S	3
FT	#SUB	254	1106 	ASN	B	202	1054 	MET	A	Protein	S	4
FT	#HET	27	 879 	ARG	B	2	1201 	0UJ	B	S	3
FT	#HET	29	 881 	LEU	B	2	1201 	0UJ	B	A	15
FT	#HET	37	 889 	VAL	B	2	1201 	0UJ	B	S	3
FT	#HET	54	 906 	ALA	B	2	1201 	0UJ	B	S	4
FT	#HET	104	 956 	MET	B	2	1201 	0UJ	B	S	1
FT	#HET	105	 957 	GLU	B	2	1201 	0UJ	B	B	3
FT	#HET	106	 958 	PHE	B	2	1201 	0UJ	B	A	5
FT	#HET	107	 959 	LEU	B	2	1201 	0UJ	B	A	7
FT	#HET	110	 962 	GLY	B	2	1201 	0UJ	B	B	1
FT	#HET	111	 963 	SER	B	2	1201 	0UJ	B	B	1
FT	#HET	114	 966 	GLU	B	2	1201 	0UJ	B	S	13
FT	#HET	155	1007 	ARG	B	2	1201 	0UJ	B	B	2
FT	#HET	156	1008 	ASN	B	2	1201 	0UJ	B	S	2
FT	#HET	158	1010 	LEU	B	2	1201 	0UJ	B	S	13
FT	#HET	168	1020 	GLY	B	2	1201 	0UJ	B	B	4
FT	#HET	169	1021 	ASP	B	2	1201 	0UJ	B	S	5
FT	DISORDER	1	11
FT	DISORDER	62	64
FT	DISORDER	95	96
CC	SEQUENCE	286 AA (ATOM);
CC	EVDPTHFEKR FLKRIRDLGE GHFGKVELCR YDPEGDNTGE QVAVKSLKPE NHIADLKKEI
CC	EILRNLYHEN IVKYKGICTE GNGIKLIMEF LPSGSLKEYL PKNKNKINLK QQLKYAVQIC
CC	KGMDYLGSRQ YVHRDLAARN VLVESEHQVK IGDFGLTKAI ETDKEYYTVK DDRDSPVFWY
CC	APECLMQSKF YIASDVWSFG VTLHELLTYC DSDSSPMALF LKMIGPTHGQ MTVTRLVNTL
CC	KEGKRLPCPP NCPDEVYQLM RKCWEFQPSN RTSFQNLIEG FEALLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   -----------EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                  ***************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKPE---NHIADLKKEIEILRNLYHENIVKYKGICTE--GNGI
CC	       ***********   ******************************  ****
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//