Brand  (β version)

PDB ID: 4F3A

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Ligands
Code Name Style Show Link
FE2 Fe (II) ion PoSSuM
IR3 Iridium (III) ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4F3A   PDBj   RCSB PDB   PDBe
Header : ISOMERASE, HYDROLASE
Title : Structure of RPE65: P6522 crystal form, iridium derivative
Release Data : 2012-10-03
Compound :
mol_id molecule chains synonym
1 Retinoid isomerohydrolase A RPE65, retinoid isomerase, All-trans-retinyl-palmitate hydrolase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase
ec: 3.1.1.64
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
tissue: retina
Authors : Kiser, P.D., Palczewski, K.
Keywords : monotopic membrane protein, metalloprotein, non-heme iron protein, Beta-propeller, smooth ER membrane, ISOMERASE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis.

Kiser, P.D.,Farquhar, E.R.,Shi, W.  et al.
(2012)  Proc.Natl.Acad.Sci.USA  109 : E2747 - E2756

PubMed: 23012475
DOI: 10.1073/pnas.1212025109

Reaction

Chain : A
UniProt : Q28175 (RPE65_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+) 3.1.1.64 PubMed:16096063, PubMed:19805034, PubMed:20100834
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lutein = (3R,3'S)-zeaxanthin 5.3.3.22 UniProtKB:Q16518
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all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + H(+) + hexadecanoate 3.1.1.64 UniProtKB:Q16518
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