Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0SE 2-(1-{[2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)pyrido[3,2-D]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
Code : 4EZL
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf
Release Data : 2013-04-17
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform A PI3-kinase subunit gamma, PI3K-gamma, PI3Kgamma, PtdIns-3-kinase subunit gamma, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, PtdIns-3-kinase subunit p110-gamma, p110gamma, Phosphoinositide-3-kinase catalytic gamma polypeptide, Serine/threonine protein kinase PIK3CG, p120-PI3K
ec: 2.7.1.153, 2.7.11.1
fragment: UNP residues 144-1102
mutation: K802T
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PIK3CG
expression_system_common: Fall armyworm
expression_system_cell_line: Sf9
expression_system_vector_type: plasmid
Authors : Murray, J.M.
Keywords : kinase p110, p110-gamma, lipid kinase, cytoplasmic, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.94 Å )
Citation :

Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf

Sutherlin, D.P.,Baker, S.,Bisconte, A.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 4296 - 4302

PubMed: 22672799
DOI: 10.1016/j.bmcl.2012.05.027

Chain : A
UniProt : P48736 (PK3CG_HUMAN)
Reaction : ATP + 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5- trisphosphate.
ATP + a protein = ADP + a phosphoprotein.