ID	4EZLA	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 4EZL
DE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isof
DE	orm
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.940
CC	R-Factor	0.245
FT	#HET	662	 804 	MET	A	1	1201 	0SE	A	A	5
FT	#HET	670	 812 	TRP	A	1	1201 	0SE	A	S	1
FT	#HET	689	 831 	ILE	A	1	1201 	0SE	A	S	3
FT	#HET	691	 833 	LYS	A	1	1201 	0SE	A	S	2
FT	#HET	696	 838 	LEU	A	1	1201 	0SE	A	S	1
FT	#HET	699	 841 	ASP	A	1	1201 	0SE	A	S	4
FT	#HET	737	 879 	ILE	A	1	1201 	0SE	A	S	4
FT	#HET	738	 880 	GLU	A	1	1201 	0SE	A	B	2
FT	#HET	739	 881 	ILE	A	1	1201 	0SE	A	A	6
FT	#HET	740	 882 	VAL	A	1	1201 	0SE	A	A	9
FT	#HET	745	 887 	THR	A	1	1201 	0SE	A	S	3
FT	#HET	811	 953 	MET	A	1	1201 	0SE	A	S	9
FT	#HET	821	 963 	ILE	A	1	1201 	0SE	A	S	6
FT	#HET	822	 964 	ASP	A	1	1201 	0SE	A	A	12
FT	DISORDER	110	124
FT	DISORDER	179	214
FT	DISORDER	294	317
FT	DISORDER	348	354
FT	DISORDER	381	382
FT	DISORDER	386	401
FT	DISORDER	613	615
FT	DISORDER	825	838
FT	DISORDER	952	966
CC	SEQUENCE	834 AA (ATOM);
CC	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
CC	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKE QDFVLRVCGR
CC	DEYLVGETPI KNFQWVRHCL KNGEEIHVVL DTPPDPALDE VRKCDRKFRV KIRGIDIPVL
CC	PRNTDLTVFV EANIQHGQQV LCQRRTSPKP FTEEVLWNVW LEFSIKIKDL PKGALLNLQI
CC	YCLLYYVNLL LIDHRFLLRR GEYVLHMWQI SGFNADKLTS ATNPDKENSM SISILLDNHP
CC	IRAEMPNQLR KQLEAIIATD PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE
CC	IVAKTYQLLA RREVWDQSAL DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ
CC	LVQAVKFEPY HDSALARFLL KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR
CC	GCGTAMLHDF TQQVQVIEML QKVTLDIKSL SADVSSQVIS QLKQKLENLQ NSQLPESFRV
CC	PYDPGLKAGA LAIEKCTVMA SKKKPLWLEF KCADPTALSN ETIGIIFKHG DDLRQDMLIL
CC	QILRIMESIW ETESLDLCLL PYGCISTGDK IGMIEIVKDA TTIAKIQQST VGNTGAFKDE
CC	VLNHWLKEKS PTEEKFQAAV ERFVYSCAGY CVATFVLGIG DRHNDNIMIT ETGNLFHIDF
CC	GERVPFVLTP DFLFVMGTSG KKTSPHFQKF QDICVKAYLA LRHHTNLLII LFSMMLMTGM
CC	PQLTSKEDIE YIRDALTVGK NEEDAKKYFL DQIEVCRDKG WTVQFNWFLH LVLG
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	       **************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTK---------------EQDFVLRVCGRDEYLVGETPIKNFQW
CC	       *********               **************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRK----------------------
CC	       ****************************                      
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   --------------CDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	                     ************************************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   -----------------LLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                        ******************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDN--HPI---------------
CC	           **************************  ***               
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   -RAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	        *************************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLSA---DVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       ************   ***********************************
CC	SEQRES AGALAIEKCTVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCTVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       **************************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFG--------------ERVPFVLTPDFL
CC	       ************************              ************
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	       **************************************************
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   G---------------
CC	       *               
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVQLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCT
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//