Brand  (β version)

PDB ID: 4EDV

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Ligands
Code Name Style Show Link
0O2 Guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate) PoSSuM
BEN Benzamidine PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 4EDV   PDBj   RCSB PDB   PDBe
Header : transferase/transferase inhibitor
Title : The structure of the S. aureus DnaG RNA Polymerase Domain bound to pppGpp and Manganese
Release Data : 2012-07-25
Compound :
mol_id molecule chains
1 DNA primase A
ec: 2.7.7.-
fragment: unp residues 111-436
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:1280) Escherichia coli  (taxid:469008)
gene: dnaG
expression_system_strain: BL21(DE3) codon+
expression_system_vector_type: plasmid
expression_system_plasmid: pET28b
Authors : Rymer, R.U., Solorio, F.A., Chu, C., Corn, J.E., Wang, J.D., Berger, J.M.
Keywords : Catalytic Domain, Bacterial, nucleotide, nucleoside triphosphate, nucleoside polyphosphate, protein-ligand complex, transferase, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.0100 Å )
Citation :

Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases.

Rymer, R.U.,Solorio, F.A.,Tehranchi, A.K.  et al.
(2012)  Structure  20 : 1478 - 1489

PubMed: 22795082
DOI: 10.1016/j.str.2012.05.017

Reaction

Chain : A
UniProt : O05338 (DNAG_STAAU)
Reaction: EC: Evidence:
Physiological Direction:
ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate. 2.7.7.101 HAMAP-Rule:MF_00974
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