Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
0NH 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine
Modified Residues
Code Name Link
PTR O-phosphotyrosine
Code : 4E4L
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : JAK1 kinase (JH1 domain) in complex with compound 30
Release Data : 2012-05-30
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK1 A,B,E,D Janus kinase 1, JAK-1
ec: 2.7.10.2
fragment: protein kinase domain JH1, UNP residues 854-1154
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK1, JAK1A, JAK1B
expression_system_common: Fall armyworm
Authors : Eigenbrot, C.
Keywords : o-phosphotyrosine, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.

Kulagowski, J.J.,Blair, W.,Bull, R.J.  et al.
(2012)  J.Med.Chem.  55 : 5901 - 5921

PubMed: 22591402
DOI: 10.1021/jm300438j

Chain : A, B, E, D
UniProt : P23458 (JAK1_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.