ID	4E4LA	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E4L
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.191
FT	#SUB	185	1037 	VAL	A	251	1103 	ARG	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	244	1096 	HIS	B	Protein	B	2
FT	#SUB	186	1038 	LYS	A	251	1103 	ARG	B	Protein	B	1
FT	#SUB	188	1040 	ASP	A	244	1096 	HIS	B	Protein	S	8
FT	#SUB	188	1040 	ASP	A	247	1099 	MET	B	Protein	A	9
FT	#SUB	188	1040 	ASP	A	251	1103 	ARG	B	Protein	S	7
FT	#SUB	189	1041 	ARG	A	243	1095 	THR	B	Protein	S	6
FT	#SUB	189	1041 	ARG	A	244	1096 	HIS	B	Protein	A	2
FT	#SUB	189	1041 	ARG	A	245	1097 	GLY	B	Protein	S	1
FT	#SUB	189	1041 	ARG	A	246	1098 	GLN	B	Protein	B	2
FT	#SUB	191	1043 	SER	A	246	1098 	GLN	B	Protein	B	1
FT	#SUB	193	1045 	VAL	A	247	1099 	MET	B	Protein	S	1
FT	#SUB	201	1053 	LEU	A	247	1099 	MET	B	Protein	B	1
FT	#SUB	201	1053 	LEU	A	250	1102 	THR	B	Protein	B	4
FT	#SUB	202	1054 	MET	A	250	1102 	THR	B	Protein	B	3
FT	#SUB	202	1054 	MET	A	254	1106 	ASN	B	Protein	B	2
FT	#SUB	203	1055 	GLN	A	254	1106 	ASN	B	Protein	S	1
FT	#SUB	204	1056 	SER	A	251	1103 	ARG	B	Protein	S	4
FT	#SUB	243	1095 	THR	A	189	1041 	ARG	B	Protein	A	5
FT	#SUB	244	1096 	HIS	A	186	1038 	LYS	B	Protein	S	2
FT	#SUB	244	1096 	HIS	A	188	1040 	ASP	B	Protein	A	8
FT	#SUB	244	1096 	HIS	A	189	1041 	ARG	B	Protein	B	2
FT	#SUB	245	1097 	GLY	A	189	1041 	ARG	B	Protein	B	1
FT	#SUB	246	1098 	GLN	A	189	1041 	ARG	B	Protein	S	3
FT	#SUB	246	1098 	GLN	A	191	1043 	SER	B	Protein	S	2
FT	#SUB	246	1098 	GLN	A	193	1045 	VAL	B	Protein	S	1
FT	#SUB	246	1098 	GLN	A	249	1101 	VAL	B	Protein	B	1
FT	#SUB	247	1099 	MET	A	188	1040 	ASP	B	Protein	S	9
FT	#SUB	247	1099 	MET	A	193	1045 	VAL	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	201	1053 	LEU	B	Protein	S	1
FT	#SUB	247	1099 	MET	A	249	1101 	VAL	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	246	1098 	GLN	B	Protein	S	1
FT	#SUB	249	1101 	VAL	A	250	1102 	THR	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	201	1053 	LEU	B	Protein	S	4
FT	#SUB	250	1102 	THR	A	202	1054 	MET	B	Protein	S	1
FT	#SUB	250	1102 	THR	A	249	1101 	VAL	B	Protein	S	1
FT	#SUB	251	1103 	ARG	A	185	1037 	VAL	B	Protein	S	2
FT	#SUB	251	1103 	ARG	A	186	1038 	LYS	B	Protein	S	3
FT	#SUB	251	1103 	ARG	A	188	1040 	ASP	B	Protein	S	7
FT	#SUB	251	1103 	ARG	A	204	1056 	SER	B	Protein	S	3
FT	#SUB	254	1106 	ASN	A	202	1054 	MET	B	Protein	S	2
FT	#SUB	144	 996 	SER	A	24	 876 	LYS	E	Protein	A	3
FT	#SUB	179	1031 	ASP	A	20	 872 	LYS	E	Protein	A	6
FT	#SUB	285	1137 	SER	A	25	 877 	ARG	E	Protein	B	1
FT	#SUB	285	1137 	SER	A	28	 880 	ASP	E	Protein	B	3
FT	#SUB	287	1139 	ARG	A	25	 877 	ARG	E	Protein	B	3
FT	#SUB	289	1141 	SER	A	25	 877 	ARG	E	Protein	S	3
FT	#SUB	289	1141 	SER	A	26	 878 	ILE	E	Protein	A	5
FT	#SUB	291	1143 	GLN	A	41	 893 	ARG	E	Protein	S	1
FT	#SUB	291	1143 	GLN	A	48	 900 	ASN	E	Protein	S	5
FT	#SUB	292	1144 	ASN	A	26	 878 	ILE	E	Protein	S	1
FT	#SUB	295	1147 	GLU	A	52	 904 	GLN	E	Protein	S	1
FT	#HET	29	 881 	LEU	A	1	1201 	0NH	A	A	5
FT	#HET	30	 882 	GLY	A	1	1201 	0NH	A	B	6
FT	#HET	31	 883 	GLU	A	1	1201 	0NH	A	B	7
FT	#HET	32	 884 	GLY	A	1	1201 	0NH	A	B	1
FT	#HET	37	 889 	VAL	A	1	1201 	0NH	A	S	5
FT	#HET	54	 906 	ALA	A	1	1201 	0NH	A	S	3
FT	#HET	104	 956 	MET	A	1	1201 	0NH	A	S	2
FT	#HET	105	 957 	GLU	A	1	1201 	0NH	A	B	3
FT	#HET	106	 958 	PHE	A	1	1201 	0NH	A	A	5
FT	#HET	107	 959 	LEU	A	1	1201 	0NH	A	B	4
FT	#HET	110	 962 	GLY	A	1	1201 	0NH	A	B	1
FT	#HET	155	1007 	ARG	A	1	1201 	0NH	A	A	5
FT	#HET	156	1008 	ASN	A	1	1201 	0NH	A	S	3
FT	#HET	158	1010 	LEU	A	1	1201 	0NH	A	S	13
FT	#HET	168	1020 	GLY	A	1	1201 	0NH	A	B	3
FT	#HET	169	1021 	ASP	A	1	1201 	0NH	A	S	4
FT	DISORDER	1	12
FT	DISORDER	60	65
FT	DISORDER	94	98
CC	SEQUENCE	279 AA (ATOM);
CC	VDPTHFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKHIA DLKKEIEILR
CC	NLYHENIVKY KGICTGIKLI MEFLPSGSLK EYLPKNKNKI NLKQQLKYAV QICKGMDYLG
CC	SRQYVHRDLA ARNVLVESEH QVKIGDFGLT KAIETDKEYY TVKDDRDSPV FWYAPECLMQ
CC	SKFYIASDVW SFGVTLHELL TYCDSDSSPM ALFLKMIGPT HGQMTVTRLV NTLKEGKRLP
CC	CPPNCPDEVY QLMRKCWEFQ PSNRTSFQNL IEGFEALLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   ------------VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                   **************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLK------HIADLKKEIEILRNLYHENIVKYKGICT-----GI
CC	       *********      ****************************     **
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4E4LB	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E4L
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.191
FT	#SUB	185	1037 	VAL	B	251	1103 	ARG	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	244	1096 	HIS	A	Protein	B	2
FT	#SUB	186	1038 	LYS	B	251	1103 	ARG	A	Protein	B	3
FT	#SUB	188	1040 	ASP	B	244	1096 	HIS	A	Protein	S	8
FT	#SUB	188	1040 	ASP	B	247	1099 	MET	A	Protein	A	9
FT	#SUB	188	1040 	ASP	B	251	1103 	ARG	A	Protein	S	7
FT	#SUB	189	1041 	ARG	B	243	1095 	THR	A	Protein	S	5
FT	#SUB	189	1041 	ARG	B	244	1096 	HIS	A	Protein	A	2
FT	#SUB	189	1041 	ARG	B	245	1097 	GLY	A	Protein	S	1
FT	#SUB	189	1041 	ARG	B	246	1098 	GLN	A	Protein	B	3
FT	#SUB	191	1043 	SER	B	246	1098 	GLN	A	Protein	B	2
FT	#SUB	193	1045 	VAL	B	246	1098 	GLN	A	Protein	S	1
FT	#SUB	193	1045 	VAL	B	247	1099 	MET	A	Protein	S	1
FT	#SUB	201	1053 	LEU	B	247	1099 	MET	A	Protein	B	1
FT	#SUB	201	1053 	LEU	B	250	1102 	THR	A	Protein	B	4
FT	#SUB	202	1054 	MET	B	250	1102 	THR	A	Protein	B	1
FT	#SUB	202	1054 	MET	B	254	1106 	ASN	A	Protein	B	2
FT	#SUB	204	1056 	SER	B	251	1103 	ARG	A	Protein	S	3
FT	#SUB	243	1095 	THR	B	189	1041 	ARG	A	Protein	A	6
FT	#SUB	244	1096 	HIS	B	186	1038 	LYS	A	Protein	S	2
FT	#SUB	244	1096 	HIS	B	188	1040 	ASP	A	Protein	A	8
FT	#SUB	244	1096 	HIS	B	189	1041 	ARG	A	Protein	B	2
FT	#SUB	245	1097 	GLY	B	189	1041 	ARG	A	Protein	B	1
FT	#SUB	246	1098 	GLN	B	189	1041 	ARG	A	Protein	S	2
FT	#SUB	246	1098 	GLN	B	191	1043 	SER	A	Protein	S	1
FT	#SUB	246	1098 	GLN	B	249	1101 	VAL	A	Protein	B	1
FT	#SUB	247	1099 	MET	B	188	1040 	ASP	A	Protein	S	9
FT	#SUB	247	1099 	MET	B	193	1045 	VAL	A	Protein	S	1
FT	#SUB	247	1099 	MET	B	201	1053 	LEU	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	246	1098 	GLN	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	247	1099 	MET	A	Protein	S	1
FT	#SUB	249	1101 	VAL	B	250	1102 	THR	A	Protein	S	1
FT	#SUB	250	1102 	THR	B	201	1053 	LEU	A	Protein	S	4
FT	#SUB	250	1102 	THR	B	202	1054 	MET	A	Protein	S	3
FT	#SUB	250	1102 	THR	B	249	1101 	VAL	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	185	1037 	VAL	A	Protein	S	2
FT	#SUB	251	1103 	ARG	B	186	1038 	LYS	A	Protein	S	1
FT	#SUB	251	1103 	ARG	B	188	1040 	ASP	A	Protein	S	7
FT	#SUB	251	1103 	ARG	B	204	1056 	SER	A	Protein	S	4
FT	#SUB	254	1106 	ASN	B	202	1054 	MET	A	Protein	S	2
FT	#SUB	254	1106 	ASN	B	203	1055 	GLN	A	Protein	S	1
FT	#HET	29	 881 	LEU	B	3	1201 	0NH	B	A	5
FT	#HET	30	 882 	GLY	B	3	1201 	0NH	B	B	4
FT	#HET	31	 883 	GLU	B	3	1201 	0NH	B	B	7
FT	#HET	32	 884 	GLY	B	3	1201 	0NH	B	B	1
FT	#HET	37	 889 	VAL	B	3	1201 	0NH	B	S	5
FT	#HET	54	 906 	ALA	B	3	1201 	0NH	B	S	3
FT	#HET	104	 956 	MET	B	3	1201 	0NH	B	S	2
FT	#HET	105	 957 	GLU	B	3	1201 	0NH	B	B	4
FT	#HET	106	 958 	PHE	B	3	1201 	0NH	B	A	4
FT	#HET	107	 959 	LEU	B	3	1201 	0NH	B	B	4
FT	#HET	110	 962 	GLY	B	3	1201 	0NH	B	B	1
FT	#HET	155	1007 	ARG	B	3	1201 	0NH	B	A	5
FT	#HET	156	1008 	ASN	B	3	1201 	0NH	B	S	3
FT	#HET	158	1010 	LEU	B	3	1201 	0NH	B	S	13
FT	#HET	168	1020 	GLY	B	3	1201 	0NH	B	B	4
FT	#HET	169	1021 	ASP	B	3	1201 	0NH	B	S	4
FT	DISORDER	1	11
FT	DISORDER	60	64
FT	DISORDER	94	98
CC	SEQUENCE	281 AA (ATOM);
CC	EVDPTHFEKR FLKRIRDLGE GHFGKVELCR YDPEGDNTGE QVAVKSLKNH IADLKKEIEI
CC	LRNLYHENIV KYKGICTGIK LIMEFLPSGS LKEYLPKNKN KINLKQQLKY AVQICKGMDY
CC	LGSRQYVHRD LAARNVLVES EHQVKIGDFG LTKAIETDKE YYTVKDDRDS PVFWYAPECL
CC	MQSKFYIASD VWSFGVTLHE LLTYCDSDSS PMALFLKMIG PTHGQMTVTR LVNTLKEGKR
CC	LPCPPNCPDE VYQLMRKCWE FQPSNRTSFQ NLIEGFEALL K
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   -----------EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                  ***************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLK-----NHIADLKKEIEILRNLYHENIVKYKGICT-----GI
CC	       *********     *****************************     **
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4E4LE	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E4L
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.191
FT	#SUB	20	 872 	LYS	E	179	1031 	ASP	A	Protein	S	6
FT	#SUB	24	 876 	LYS	E	144	 996 	SER	A	Protein	S	3
FT	#SUB	25	 877 	ARG	E	285	1137 	SER	A	Protein	S	1
FT	#SUB	25	 877 	ARG	E	287	1139 	ARG	A	Protein	S	3
FT	#SUB	25	 877 	ARG	E	289	1141 	SER	A	Protein	A	3
FT	#SUB	26	 878 	ILE	E	289	1141 	SER	A	Protein	B	5
FT	#SUB	26	 878 	ILE	E	292	1144 	ASN	A	Protein	B	1
FT	#SUB	28	 880 	ASP	E	285	1137 	SER	A	Protein	S	3
FT	#SUB	41	 893 	ARG	E	291	1143 	GLN	A	Protein	S	1
FT	#SUB	48	 900 	ASN	E	291	1143 	GLN	A	Protein	S	5
FT	#SUB	52	 904 	GLN	E	295	1147 	GLU	A	Protein	S	1
FT	#SUB	185	1037 	VAL	E	251	1103 	ARG	D	Protein	B	1
FT	#SUB	186	1038 	LYS	E	244	1096 	HIS	D	Protein	B	2
FT	#SUB	186	1038 	LYS	E	251	1103 	ARG	D	Protein	B	1
FT	#SUB	188	1040 	ASP	E	244	1096 	HIS	D	Protein	S	7
FT	#SUB	188	1040 	ASP	E	247	1099 	MET	D	Protein	A	7
FT	#SUB	188	1040 	ASP	E	251	1103 	ARG	D	Protein	S	6
FT	#SUB	189	1041 	ARG	E	243	1095 	THR	D	Protein	S	5
FT	#SUB	189	1041 	ARG	E	244	1096 	HIS	D	Protein	B	1
FT	#SUB	191	1043 	SER	E	246	1098 	GLN	D	Protein	B	1
FT	#SUB	193	1045 	VAL	E	246	1098 	GLN	D	Protein	S	2
FT	#SUB	193	1045 	VAL	E	247	1099 	MET	D	Protein	S	1
FT	#SUB	201	1053 	LEU	E	247	1099 	MET	D	Protein	B	1
FT	#SUB	201	1053 	LEU	E	250	1102 	THR	D	Protein	B	4
FT	#SUB	202	1054 	MET	E	250	1102 	THR	D	Protein	B	2
FT	#SUB	202	1054 	MET	E	254	1106 	ASN	D	Protein	B	2
FT	#SUB	204	1056 	SER	E	251	1103 	ARG	D	Protein	S	4
FT	#SUB	243	1095 	THR	E	189	1041 	ARG	D	Protein	A	4
FT	#SUB	244	1096 	HIS	E	186	1038 	LYS	D	Protein	S	2
FT	#SUB	244	1096 	HIS	E	188	1040 	ASP	D	Protein	A	8
FT	#SUB	244	1096 	HIS	E	189	1041 	ARG	D	Protein	B	1
FT	#SUB	246	1098 	GLN	E	191	1043 	SER	D	Protein	S	1
FT	#SUB	246	1098 	GLN	E	193	1045 	VAL	D	Protein	S	2
FT	#SUB	246	1098 	GLN	E	249	1101 	VAL	D	Protein	B	1
FT	#SUB	247	1099 	MET	E	188	1040 	ASP	D	Protein	S	7
FT	#SUB	247	1099 	MET	E	193	1045 	VAL	D	Protein	S	1
FT	#SUB	247	1099 	MET	E	201	1053 	LEU	D	Protein	S	1
FT	#SUB	249	1101 	VAL	E	246	1098 	GLN	D	Protein	S	1
FT	#SUB	249	1101 	VAL	E	250	1102 	THR	D	Protein	S	1
FT	#SUB	250	1102 	THR	E	201	1053 	LEU	D	Protein	S	3
FT	#SUB	250	1102 	THR	E	202	1054 	MET	D	Protein	S	2
FT	#SUB	250	1102 	THR	E	249	1101 	VAL	D	Protein	S	1
FT	#SUB	251	1103 	ARG	E	185	1037 	VAL	D	Protein	S	1
FT	#SUB	251	1103 	ARG	E	186	1038 	LYS	D	Protein	S	1
FT	#SUB	251	1103 	ARG	E	188	1040 	ASP	D	Protein	S	6
FT	#SUB	251	1103 	ARG	E	204	1056 	SER	D	Protein	S	3
FT	#SUB	254	1106 	ASN	E	202	1054 	MET	D	Protein	S	2
FT	#SUB	257	1109 	LYS	E	257	1109 	LYS	D	Protein	S	1
FT	#HET	29	 881 	LEU	E	2	1202 	0NH	A	A	4
FT	#HET	30	 882 	GLY	E	2	1202 	0NH	A	B	7
FT	#HET	31	 883 	GLU	E	2	1202 	0NH	A	B	7
FT	#HET	32	 884 	GLY	E	2	1202 	0NH	A	B	1
FT	#HET	37	 889 	VAL	E	2	1202 	0NH	A	S	5
FT	#HET	54	 906 	ALA	E	2	1202 	0NH	A	S	3
FT	#HET	104	 956 	MET	E	2	1202 	0NH	A	S	2
FT	#HET	105	 957 	GLU	E	2	1202 	0NH	A	B	3
FT	#HET	106	 958 	PHE	E	2	1202 	0NH	A	A	4
FT	#HET	107	 959 	LEU	E	2	1202 	0NH	A	B	4
FT	#HET	110	 962 	GLY	E	2	1202 	0NH	A	B	1
FT	#HET	155	1007 	ARG	E	2	1202 	0NH	A	A	4
FT	#HET	156	1008 	ASN	E	2	1202 	0NH	A	S	2
FT	#HET	158	1010 	LEU	E	2	1202 	0NH	A	S	14
FT	#HET	168	1020 	GLY	E	2	1202 	0NH	A	B	3
FT	#HET	169	1021 	ASP	E	2	1202 	0NH	A	S	4
FT	DISORDER	1	11
FT	DISORDER	61	64
FT	DISORDER	94	98
CC	SEQUENCE	282 AA (ATOM);
CC	EVDPTHFEKR FLKRIRDLGE GHFGKVELCR YDPEGDNTGE QVAVKSLKPN HIADLKKEIE
CC	ILRNLYHENI VKYKGICTGI KLIMEFLPSG SLKEYLPKNK NKINLKQQLK YAVQICKGMD
CC	YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK EYYTVKDDRD SPVFWYAPEC
CC	LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI GPTHGQMTVT RLVNTLKEGK
CC	RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL LK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   -----------EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                  ***************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLKP----NHIADLKKEIEILRNLYHENIVKYKGICT-----GI
CC	       **********    *****************************     **
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//
ID	4E4LD	STANDARD;	PRT;	302	AA.
DT	CONVERTED FROM PDB (SEQRES) 4E4L
DE	Tyrosine-protein kinase JAK1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.191
FT	#SUB	185	1037 	VAL	D	251	1103 	ARG	E	Protein	B	1
FT	#SUB	186	1038 	LYS	D	244	1096 	HIS	E	Protein	B	2
FT	#SUB	186	1038 	LYS	D	251	1103 	ARG	E	Protein	B	1
FT	#SUB	188	1040 	ASP	D	244	1096 	HIS	E	Protein	S	8
FT	#SUB	188	1040 	ASP	D	247	1099 	MET	E	Protein	A	7
FT	#SUB	188	1040 	ASP	D	251	1103 	ARG	E	Protein	S	6
FT	#SUB	189	1041 	ARG	D	243	1095 	THR	E	Protein	S	4
FT	#SUB	189	1041 	ARG	D	244	1096 	HIS	E	Protein	B	1
FT	#SUB	191	1043 	SER	D	246	1098 	GLN	E	Protein	B	1
FT	#SUB	193	1045 	VAL	D	246	1098 	GLN	E	Protein	S	2
FT	#SUB	193	1045 	VAL	D	247	1099 	MET	E	Protein	S	1
FT	#SUB	201	1053 	LEU	D	247	1099 	MET	E	Protein	B	1
FT	#SUB	201	1053 	LEU	D	250	1102 	THR	E	Protein	B	3
FT	#SUB	202	1054 	MET	D	250	1102 	THR	E	Protein	B	2
FT	#SUB	202	1054 	MET	D	254	1106 	ASN	E	Protein	B	2
FT	#SUB	204	1056 	SER	D	251	1103 	ARG	E	Protein	S	3
FT	#SUB	243	1095 	THR	D	189	1041 	ARG	E	Protein	A	5
FT	#SUB	244	1096 	HIS	D	186	1038 	LYS	E	Protein	S	2
FT	#SUB	244	1096 	HIS	D	188	1040 	ASP	E	Protein	A	7
FT	#SUB	244	1096 	HIS	D	189	1041 	ARG	E	Protein	B	1
FT	#SUB	246	1098 	GLN	D	191	1043 	SER	E	Protein	S	1
FT	#SUB	246	1098 	GLN	D	193	1045 	VAL	E	Protein	S	2
FT	#SUB	246	1098 	GLN	D	249	1101 	VAL	E	Protein	B	1
FT	#SUB	247	1099 	MET	D	188	1040 	ASP	E	Protein	S	7
FT	#SUB	247	1099 	MET	D	193	1045 	VAL	E	Protein	S	1
FT	#SUB	247	1099 	MET	D	201	1053 	LEU	E	Protein	S	1
FT	#SUB	249	1101 	VAL	D	246	1098 	GLN	E	Protein	S	1
FT	#SUB	249	1101 	VAL	D	250	1102 	THR	E	Protein	S	1
FT	#SUB	250	1102 	THR	D	201	1053 	LEU	E	Protein	S	4
FT	#SUB	250	1102 	THR	D	202	1054 	MET	E	Protein	S	2
FT	#SUB	250	1102 	THR	D	249	1101 	VAL	E	Protein	S	1
FT	#SUB	251	1103 	ARG	D	185	1037 	VAL	E	Protein	S	1
FT	#SUB	251	1103 	ARG	D	186	1038 	LYS	E	Protein	S	1
FT	#SUB	251	1103 	ARG	D	188	1040 	ASP	E	Protein	S	6
FT	#SUB	251	1103 	ARG	D	204	1056 	SER	E	Protein	S	4
FT	#SUB	254	1106 	ASN	D	202	1054 	MET	E	Protein	S	2
FT	#SUB	257	1109 	LYS	D	257	1109 	LYS	E	Protein	S	1
FT	#HET	29	 881 	LEU	D	4	1201 	0NH	D	B	2
FT	#HET	30	 882 	GLY	D	4	1201 	0NH	D	B	4
FT	#HET	31	 883 	GLU	D	4	1201 	0NH	D	B	7
FT	#HET	32	 884 	GLY	D	4	1201 	0NH	D	B	1
FT	#HET	37	 889 	VAL	D	4	1201 	0NH	D	S	5
FT	#HET	54	 906 	ALA	D	4	1201 	0NH	D	S	3
FT	#HET	104	 956 	MET	D	4	1201 	0NH	D	S	2
FT	#HET	105	 957 	GLU	D	4	1201 	0NH	D	B	4
FT	#HET	106	 958 	PHE	D	4	1201 	0NH	D	A	4
FT	#HET	107	 959 	LEU	D	4	1201 	0NH	D	B	4
FT	#HET	155	1007 	ARG	D	4	1201 	0NH	D	A	4
FT	#HET	156	1008 	ASN	D	4	1201 	0NH	D	S	2
FT	#HET	158	1010 	LEU	D	4	1201 	0NH	D	S	13
FT	#HET	168	1020 	GLY	D	4	1201 	0NH	D	B	3
FT	#HET	169	1021 	ASP	D	4	1201 	0NH	D	S	4
FT	DISORDER	1	11
FT	DISORDER	60	65
FT	DISORDER	94	95
CC	SEQUENCE	283 AA (ATOM);
CC	EVDPTHFEKR FLKRIRDLGE GHFGKVELCR YDPEGDNTGE QVAVKSLKHI ADLKKEIEIL
CC	RNLYHENIVK YKGICTGGNG IKLIMEFLPS GSLKEYLPKN KNKINLKQQL KYAVQICKGM
CC	DYLGSRQYVH RDLAARNVLV ESEHQVKIGD FGLTKAIETD KEYYTVKDDR DSPVFWYAPE
CC	CLMQSKFYIA SDVWSFGVTL HELLTYCDSD SSPMALFLKM IGPTHGQMTV TRLVNTLKEG
CC	KRLPCPPNCP DEVYQLMRKC WEFQPSNRTS FQNLIEGFEA LLK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES GDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	ATOM   -----------EVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG
CC	                  ***************************************
CC	SEQRES EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGI
CC	ATOM   EQVAVKSLK------HIADLKKEIEILRNLYHENIVKYKGICT--GGNGI
CC	       *********      ****************************  *****
CC	SEQRES KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	ATOM   KLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHR
CC	       **************************************************
CC	SEQRES DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	ATOM   DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC
CC	       **************************************************
CC	SEQRES LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	ATOM   LMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVT
CC	       **************************************************
CC	SEQRES RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	ATOM   RLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEAL
CC	       **************************************************
CC	SEQRES LK
CC	ATOM   LK
CC	       **
SQ	SEQUENCE	302 AA;      MW;         CN;
	GDIVSEKKPA TEVDPTHFEK RFLKRIRDLG EGHFGKVELC RYDPEGDNTG EQVAVKSLKP
	ESGGNHIADL KKEIEILRNL YHENIVKYKG ICTEDGGNGI KLIMEFLPSG SLKEYLPKNK
	NKINLKQQLK YAVQICKGMD YLGSRQYVHR DLAARNVLVE SEHQVKIGDF GLTKAIETDK
	EYYTVKDDRD SPVFWYAPEC LMQSKFYIAS DVWSFGVTLH ELLTYCDSDS SPMALFLKMI
	GPTHGQMTVT RLVNTLKEGK RLPCPPNCPD EVYQLMRKCW EFQPSNRTSF QNLIEGFEAL
	LK
//