Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
0JQ 2-{1-[5-(6,7-dimethoxycinnolin-4-yl)-3-methylpyridin-2-yl]piperidin-4-yl}propan-2-ol
SO4 Sulfate ion
ZN Zinc ion
Code : 4DDL
Header : Hydrolase/Hydrolase Inhibitor
Title : PDE10a Crystal Structure Complexed with Novel Inhibitor
Release Data : 2012-03-21
Compound :
mol_id molecule chains
1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A A,B
ec: 3.1.4.17, 3.1.4.35
fragment: human PDE10a, residues 442-779
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PDE10A
Authors : Chmait, S., Jordan, S., Zhang, J.
Keywords : Phosphodiesterase 10a, Hydrolase, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.07 Å )
Citation :

Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors.

Hu, E.,Kunz, R.K.,Rumfelt, S.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 2262 - 2265

PubMed: 22365755
DOI: 10.1016/j.bmcl.2012.01.086

Chain : A, B
UniProt : Q9Y233 (PDE10_HUMAN)
Reaction : Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.