Brand  (β version)

PDB ID: 3WIG

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Ligands
Code Name Style Show Link
ANP Phosphoaminophosphonic acid-adenylate ester PoSSuM
MG Magnesium ion PoSSuM
CHU N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2h-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide PoSSuM
PG4 Tetraethylene glycol PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3WIG   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP
Release Data : 2014-06-04
Compound :
mol_id molecule chains synonym
1 Dual specificity mitogen-activated protein kinase kinase 1 A MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1, MEK 1
ec: 2.7.12.2
other_details: UNP RESIDUES 62-270, 303-393
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MAP2K1, MEK1, PRKMK1
expression_system_vector_type: plasmid
Authors : Lukacs, C.M., Janson, C., Schuck, V.
Keywords : kinase, kinase inhibitor, allosteric, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.7000 Å )
Citation :

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Lito, P.,Saborowski, A.,Yue, J.  et al.
(2014)  Cancer Cell  25 : 697 - 710

PubMed: 24746704
DOI: 10.1016/j.ccr.2014.03.011

Reaction

Chain : A
UniProt : Q02750 (MP2K1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.12.2 -
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.12.2 -
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.12.2 -
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