ID	3WIGA	STANDARD;	PRT;	307	AA.
DT	CONVERTED FROM PDB (SEQRES) 3WIG
DE	Dual specificity mitogen-activated protein kinase kinase 1
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.700
CC	R-Factor	0.217
FT	#HET	14	  75 	LEU	A	1	401 	ANP	A	A	5
FT	#HET	15	  76 	GLY	A	1	401 	ANP	A	B	6
FT	#HET	16	  77 	ALA	A	1	401 	ANP	A	B	7
FT	#HET	17	  78 	GLY	A	1	401 	ANP	A	B	5
FT	#HET	22	  83 	VAL	A	1	401 	ANP	A	S	6
FT	#HET	35	  96 	ALA	A	1	401 	ANP	A	S	3
FT	#HET	37	  98 	LYS	A	1	401 	ANP	A	S	5
FT	#HET	37	  98 	LYS	A	2	402 	MG	A	S	1
FT	#HET	42	 103 	GLU	A	9	409 	CL	A	B	1
FT	#HET	55	 116 	LEU	A	3	403 	CHU	A	S	1
FT	#HET	58	 119 	LEU	A	3	403 	CHU	A	S	5
FT	#HET	67	 128 	VAL	A	3	403 	CHU	A	A	5
FT	#HET	68	 129 	GLY	A	3	403 	CHU	A	B	1
FT	#HET	69	 130 	PHE	A	3	403 	CHU	A	S	1
FT	#HET	81	 142 	ILE	A	3	403 	CHU	A	S	6
FT	#HET	83	 144 	MET	A	3	403 	CHU	A	S	3
FT	#HET	84	 145 	GLU	A	1	401 	ANP	A	B	2
FT	#HET	85	 146 	HIS	A	1	401 	ANP	A	A	3
FT	#HET	86	 147 	MET	A	1	401 	ANP	A	A	6
FT	#HET	90	 151 	SER	A	1	401 	ANP	A	A	5
FT	#HET	93	 154 	GLN	A	1	401 	ANP	A	S	4
FT	#HET	121	 182 	ARG	A	5	405 	CL	A	S	2
FT	#HET	125	 186 	LYS	A	4	404 	PG4	A	B	1
FT	#HET	128	 189 	HIS	A	3	403 	CHU	A	B	1
FT	#HET	129	 190 	ARG	A	3	403 	CHU	A	A	8
FT	#HET	130	 191 	ASP	A	3	403 	CHU	A	S	6
FT	#HET	132	 193 	LYS	A	1	401 	ANP	A	S	5
FT	#HET	134	 195 	SER	A	1	401 	ANP	A	S	6
FT	#HET	135	 196 	ASN	A	1	401 	ANP	A	S	1
FT	#HET	135	 196 	ASN	A	2	402 	MG	A	S	3
FT	#HET	137	 198 	LEU	A	1	401 	ANP	A	S	4
FT	#HET	147	 208 	CYS	A	3	403 	CHU	A	A	3
FT	#HET	148	 209 	ASP	A	1	401 	ANP	A	S	1
FT	#HET	148	 209 	ASP	A	2	402 	MG	A	S	3
FT	#HET	148	 209 	ASP	A	3	403 	CHU	A	A	10
FT	#HET	149	 210 	PHE	A	3	403 	CHU	A	A	13
FT	#HET	150	 211 	GLY	A	3	403 	CHU	A	B	6
FT	#HET	150	 211 	GLY	A	4	404 	PG4	A	B	1
FT	#HET	151	 212 	VAL	A	3	403 	CHU	A	A	8
FT	#HET	151	 212 	VAL	A	4	404 	PG4	A	B	3
FT	#HET	152	 213 	SER	A	3	403 	CHU	A	A	4
FT	#HET	153	 214 	GLY	A	4	404 	PG4	A	B	5
FT	#HET	155	 216 	LEU	A	3	403 	CHU	A	A	6
FT	#HET	156	 217 	ILE	A	3	403 	CHU	A	A	11
FT	#HET	156	 217 	ILE	A	4	404 	PG4	A	S	1
FT	#HET	159	 220 	MET	A	3	403 	CHU	A	S	3
FT	#HET	161	 222 	ASN	A	3	403 	CHU	A	S	8
FT	#HET	162	 223 	SER	A	3	403 	CHU	A	S	1
FT	#HET	166	 227 	THR	A	6	406 	CL	A	A	2
FT	#HET	167	 228 	ARG	A	6	406 	CL	A	S	2
FT	#HET	181	 242 	SER	A	5	405 	CL	A	S	1
FT	#HET	182	 243 	VAL	A	5	405 	CL	A	A	2
FT	#HET	239	 331 	SER	A	8	408 	CL	A	A	2
FT	#HET	240	 332 	LEU	A	8	408 	CL	A	B	1
FT	#HET	279	 371 	PHE	A	7	407 	CL	A	B	1
FT	#HET	280	 372 	ALA	A	7	407 	CL	A	B	1
FT	DISORDER	18	20
FT	DISORDER	207	213
FT	DISORDER	289	307
CC	SEQUENCE	278 AA (ATOM);
CC	MELKDDDFEK ISELGAGVVF KVSHKPSGLV MARKLIHLEI KPAIRNQIIR ELQVLHECNS
CC	PYIVGFYGAF YSDGEISICM EHMDGGSLDQ VLKKAGRIPE QILGKVSIAV IKGLTYLREK
CC	HKIMHRDVKP SNILVNSRGE IKLCDFGVSG QLIDSMANSF VGTRSYMSPE RLQGTHYSVQ
CC	SDIWSMGLSL VEMAVGRYPI PPPPPMAIFE LLDYIVNEPP PKLPSGVFSL EFQDFVNKCL
CC	IKNPAERADL KQLMVHAFIK RSDAEEVDFA GWLCSTIG
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQ
CC	ATOM   MELKDDDFEKISELGAG---VVFKVSHKPSGLVMARKLIHLEIKPAIRNQ
CC	       *****************   ******************************
CC	SEQRES IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR
CC	ATOM   IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR
CC	       **************************************************
CC	SEQRES IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG
CC	ATOM   IPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFG
CC	       **************************************************
CC	SEQRES VSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR
CC	ATOM   VSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR
CC	       **************************************************
CC	SEQRES YPIPPPDAKEDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL
CC	ATOM   YPIPPP-------PPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCL
CC	       ******       *************************************
CC	SEQRES IKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAG
CC	ATOM   IKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIG------------
CC	       **************************************            
CC	SEQRES VHHHHHH
CC	ATOM   -------
CC	              
SQ	SEQUENCE	307 AA;      MW;         CN;
	MELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE
	CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL
	REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY
	SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE DSRPPMAIFE LLDYIVNEPP PKLPSGVFSL
	EFQDFVNKCL IKNPAERADL KQLMVHAFIK RSDAEEVDFA GWLCSTIGLN QPSTPTHAAG
	VHHHHHH
//