PDB ID: 3TIK
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
HEM | Protoporphyrin ix containing Fe | PoSSuM | |||
JKF | 6-[(R)-(4-chlorophenyl)(methoxy)(1-methyl-1h-imidazol-5-yl)methyl]-4-(2,6-difluorophenyl)-1-methylquinolin-2(1h)-one | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|
Download interaction data: 3TIK
Structure summary
Code : | 3TIK PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the tipifarnib derivative 6-((4-chlorophenyl)(methoxy)(1-methyl-1H-imidazol-5-yl)methyl)-4-(2,6-difluorophenyl)-1-methylquinolin-2(1H)-one | ||||||||||||
Release Data : | 2012-07-11 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Hargrove, T.Y., Wawrzak, Z., Kraus, J.M., Gelb, M.H., Buckner, F.S., Waterman, M.R., Lepesheva, G.I. | ||||||||||||
Keywords : | STEROL 14-ALPHA DEMETHYLASE, CYP51, HEME, MONOOXYGENASE, STEROL BIOSYNTHESIS, Cytochrome P450 fold, oxidoreductase, cytochrome P450 reductase, endoplasmic reticulum membrane | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.05 Å ) | ||||||||||||
Citation : |
Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from tipifarnib.
Buckner, F.S.,Bahia, M.T.,Suryadevara, P.K.
et al.
PubMed: 22777048 |
Reaction
Chain : | A, B, C, D |
---|---|
UniProt : | Q385E8 (Q385E8_TRYB2) |
Reaction : | - |