PDB ID: 3SFF
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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0DI | (2r)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one | PoSSuM | |||
K | Potassium ion | PoSSuM | |||
ZN | Zinc ion | PoSSuM |
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Download interaction data: 3SFF
Structure summary
Code : | 3SFF PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor | ||||||||||||
Release Data : | 2011-07-20 | ||||||||||||
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Authors : | Stams, T., Vash, B. | ||||||||||||
Keywords : | deacetylase, NVP-LCI785, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.00 Å ) | ||||||||||||
Citation : |
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
Whitehead, L.,Dobler, M.R.,Radetich, B.
et al.
PubMed: 21723733 |
Reaction
Chain : | A | ||||||||||||||||
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UniProt : | Q9BY41 (HDAC8_HUMAN) | ||||||||||||||||
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