Brand  (β version)

PDB ID: 3PRF

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Ligands
Code Name Style Show Link
FP3 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-C]pyridin-3-yl]amino}phenol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3PRF   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor
Release Data : 2011-02-02
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase B-raf A,B Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
ec: 2.7.11.1
fragment: Kinase domain, UNP residues 432-726
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: BRAF, BRAF1, RAFB1
expression_system_common: Cabbage looper
expression_system_strain: Hi5
expression_system_vector_type: baculovirus
expression_system_plasmid: pBac4x-1
Authors : Voegtli, W.C., Vigers, G.P.A., Morales, T., Brandhuber, B.J.
Keywords : Protein Kinase, ATP-competitive inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Non-oxime inhibitors of B-Raf(V600E) kinase.

Ren, L.,Wenglowsky, S.,Miknis, G.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 1243 - 1247

PubMed: 21251822
DOI: 10.1016/j.bmcl.2010.12.061

Reaction

Chain : A, B
UniProt : P15056 (BRAF_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:21441910, PubMed:29433126
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:21441910
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